Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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New 5-HT6 receptor ligands from the group of sulfonamide derivatives of cyclic arylguanidines in the treatment of glioblastoma multiforme.

2020/37/N/NZ7/02120

Keywords:

5-HT6 serotonin glioblastoma synthesis microwave sonochemistry molecular modeling low-base ligands sulfonamides guanidines

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Politechnika Krakowska im. Tadeusza Kościuszki, Wydział Inżynierii i Technologii Chemicznej

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Przemysław Patryk Zaręba 

Number of co-investigators in the project: 3

Call: PRELUDIUM 19 - announced on 2020-03-16

Amount awarded: 209 880 PLN

Project start date (Y-m-d): 2021-03-26

Project end date (Y-m-d): 2024-03-25

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. Low-basicity 5-HT6 receptor ligands from the group of cyclic arylguanidine derivatives and their antiproliferative activity evaluation
    Authors:
    Przemysław Zaręba, Anna K. Drabczyk, Artur Wnorowski, Maciej Maj, Katarzyna Malarz, Patryk Rurka, Gniewomir Latacz, Beata Duszyńska, Krzesimir Ciura, Katrzyna Ewa Greber, Anna Boguszewska-Czubara, Paweł Śliwa, Julia Kuliś
    Academic press:
    International Journal of Molecular Sciences (rok: 2024, tom: -, strony: -), Wydawca: MDPI
    Status:
    Submitted
  2. Eco-friendly methods of synthesis and preliminary biological evaluation of sulfonamide derivatives of cyclic arylguanidines
    Authors:
    Przemysław Zaręba, Anna K. Drabczyk, Artur Wnorowski, Edyta Pindelska, Gniewomir Latacz, Jolanta Jaśkowska
    Academic press:
    Ultrasonics Sonochemistry (rok: 2022, tom: 90, strony: 106165), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ultsonch.2022.106165 - link to the publication
  3. Eco-friendly methods of synthesis and preliminary biological evaluation of sulfonamide derivatives of cyclic arylguanidines
    Authors:
    Przemysław Zaręba, Anna K. Drabczyk, Artur Wnorowski, Edyta Pindelska, Gniewomir Latacz, Jolanta Jaśkowska
    Academic press:
    Ultrasonics Sonochemistry (rok: 2022, tom: 90, strony: 106165), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ultsonch.2022.106165 - link to the publication
  4. Long-chain cyclic arylguanidines as multifunctional serotonin receptors ligands with antiproliferative activity
    Authors:
    Przemysław Zaręba, Anna K. Drabczyk, Artur Wnorowski, Maciej Maj, Katarzyna Malarz, Patryk Rurka, Gniewomir Latacz, Krystyna Nędza, Krzesimir Ciura, Katrzyna Ewa Greber, Anna Boguszewska-Czubara, Paweł Śliwa, Julia Kuliś
    Academic press:
    ACS Omega (rok: 2024, tom: -, strony: -), Wydawca: ACS Publications
    Status:
    Submitted

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