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Information on the principal investigator and host institution

Information of the project and the call

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Thermodynamics of the interaction of betacoronaviruses with human cel receptor.

2020/37/B/NZ6/01476

Keywords:

betacoronaviruses SARS isothermal titration calorimetry (ITC) ACE2 receptor spike (S) protein

Descriptors:

  • NZ6_5: Virology
  • NZ3_1: Cell biology
  • ST4_9: Biological chemistry

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Opolski

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Danuta Witkowska 

Number of co-investigators in the project: 2

Call: OPUS 19 - announced on 2020-03-16

Amount awarded: 703 200 PLN

Project start date (Y-m-d): 2021-02-15

Project end date (Y-m-d): 2024-10-14

Project duration:: 44 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. Thermodynamic analysis of the interactions between human ACE2 and spike RBD of Betacoronaviruses (SARS-CoV-1 and SARS-CoV-2)
    Authors:
    Agnieszka Rombel-Bryzek , Adriana Miller , Danuta Witkowska
    Academic press:
    FEBS Open Bio . (rok: 2022, tom: 13, strony: 174-184), Wydawca: John Wiley & Sons Ltd
    Status:
    Published
    DOI:
    10.1002/2211-5463.13525 - link to the publication
  2. SARS-CoV-2 and its impact on the cardiovascular and digestive systems – The interplay between new virus variants and human cells
    Authors:
    Angelika Szpulak, Urszula Garlak, Hanna Ćwirko, Bogusława Witkowska, Agnieszka Rombel-Bryzek, Danuta Witkowska
    Academic press:
    Computational and Structural Biotechnology Journal (rok: 2023, tom: 21, strony: 1022-1029), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.csbj.2023.01.024 - link to the publication
  3. Thermodynamic analysis of the interactions between human ACE2 and spike RBD of Betacoronaviruses (SARS-CoV-1 and SARS-CoV-2)
    Authors:
    Agnieszka Rombel-Bryzek , Adriana Miller , Danuta Witkowska
    Academic press:
    FEBS Open Bio . (rok: 2022, tom: 13, strony: 174-184), Wydawca: John Wiley & Sons Ltd
    Status:
    Published
    DOI:
    10.1002/2211-5463.13525 - link to the publication

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