Projects funded by the NCN

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86 projects found matching your search criteria :

  1. Design and Pharmacological Evaluation of Marine Alkaloid-Inspired 5-HT2A Receptor Ligands

    Call: PRELUDIUM 24 , Panel: NZ1

    Principal investigator: Szymon Kazimierz Kordylewski

    Instytut Farmakologii PAN

  2. Synthesis of new macrocyclic molecular receptors with torand skeleton for selective and effective metal cation detection

    Call: PRELUDIUM 24 , Panel: ST5

    Principal investigator: Stanisław Marek Kulczyk

    Politechnika Warszawska

  3. NMR Spectroscopy as Molecular Language: A Deep Learning Approach to Bioactivity Prediction

    Call: PRELUDIUM 24 , Panel: NZ7

    Principal investigator: Arkadiusz Bogumił Leniak

    Instytut Farmakologii PAN

  4. Targeting Proteinopathies: Understanding and Mitigating the Effects of Pathogenic Mutations in Cullin-RING Ubiquitin Lig...

    Call: OPUS 27 , Panel: NZ3

    Principal investigator: dr hab. Wojciech Mieczysław Pokrzywa

    Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

  5. Molecular mechanisms underlying the liver injury induced by ulipristal acetate treatment

    Call: PRELUDIUM 23 , Panel: NZ7

    Principal investigator: Aleksandra Natalia Łupińska

    Instytut Rozrodu Zwierząt i Badań Żywności PAN

  6. First-in-class dual modulators of necroptosis kinases and 5-HT6 receptors as an innovative approach to develop an effect...

    Call: OPUS 26 , Panel: NZ7

    Principal investigator: prof. Jadwiga Handzlik

    Uniwersytet Jagielloński, Collegium Medicum

  7. Integrated multi-omics approach to accelerate anticancer drug discovery by targeting metabolic reprogramming in human co...

    Call: OPUS 26 , Panel: NZ7

    Principal investigator: dr hab. Danuta Dudzik

    Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

  8. Crownphyrins - hybrids of crown ethers and porphyrins, constituting macrocyclic platforms for the construction of two- a...

    Call: PRELUDIUM BIS 5 , Panel: ST4

    Principal investigator: dr hab. Bartosz Jakub Szyszko

    Uniwersytet Wrocławski, Wydział Chemii

  9. Molecular geometry – pre- and post-synthetically modified shape-persistent macrocycles of great chiroptical response, fo...

    Call: OPUS 25 , Panel: ST5

    Principal investigator: prof. Marcin Grzegorz Kwit

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

  10. "I like to move it, move it" – molecular dynamics-driven optimization of ligand residence time as an opportunity to impr...

    Call: OPUS 25 , Panel: NZ7

    Principal investigator: dr hab. Sabina Marta Podlewska

    Instytut Farmakologii PAN

  11. Psychedelic-induced molecular changes in the brain

    Call: SONATINA 7 , Panel: NZ2

    Principal investigator: dr Dominik Łukasz Cysewski

    Uniwersytet Medyczny w Białymstoku

  12. Molecular implications of gut microbiota disorders in the context of the immune system functioning in patients with prim...

    Call: OPUS 23 , Panel: NZ6

    Principal investigator: prof. Ewelina Pia Grywalska

    Uniwersytet Medyczny w Lublinie

  13. Proinsulin C-peptide and G protein-coupled receptor 146 (GPR146) – clinical investigation of the impact of their signall...

    Call: PRELUDIUM 21 , Panel: NZ4

    Principal investigator: Aleksandra Ryk

    Uniwersytet Medyczny w Łodzi, Wydział Lekarski

  14. The evaluation of therapeutic potential of β-caryophyllene in animal schizophrenia model - behavioral and molecular stud...

    Call: PRELUDIUM 21 , Panel: NZ7

    Principal investigator: dr Magdalena Białoń

    Instytut Farmakologii PAN

  15. Synthesis and applications of sumanene derivatives as innovative, selective and effective molecular receptors of caesium...

    Call: OPUS 22 , Panel: ST4

    Principal investigator: dr Artur Kasprzak

    Politechnika Warszawska, Wydział Chemiczny

  16. Brain GABAB receptors as determinants of obesity phenotypes: evaluation of adolescent female and male rats

    Call: OPUS 22 , Panel: NZ5

    Principal investigator: prof. Małgorzata Maria Filip

    Instytut Farmakologii PAN

  17. The interplay of neurochemistry and cancer biology: in the search for novel glioblastoma multiforme therapy among dopami...

    Call: SONATA 17 , Panel: NZ7

    Principal investigator: dr Katarzyna Maria Kucwaj-Brysz

    Uniwersytet Jagielloński, Collegium Medicum

  18. FGFR2-->JunB axis in progression of ER+ breast cancer - molecular analyses and prognostication

    Call: PRELUDIUM BIS 3 , Panel: NZ3

    Principal investigator: dr hab. Rafał Sebastian Sądej

    Gdański Uniwersytet Medyczny, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

  19. Molecular mechanisms of 5-HT7R-mediated resilience in stress-related disorders

    Call: OPUS 21 , Panel: NZ4

    Principal investigator: prof. Jakub Mateusz Włodarczyk

    Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

  20. Design of metal-peptide complexes based on amyloid β sequence with a His-2 binding motif as selective receptors in elect...

    Call: PRELUDIUM 20 , Panel: ST4

    Principal investigator: Aleksandra Magdalena Tobolska

    Politechnika Warszawska

  21. Blocking the TNF-TNFR2 interactions as a novel approach to the ovarian carcinoma treatment

    Call: OPUS 21 , Panel: NZ7

    Principal investigator: prof. Sylwia Anna Rodziewicz-Motowidło

    Uniwersytet Gdański, Wydział Chemii

  22. Cooperative and collective phenomena in cell membrane adhesion

    Call: SHENG 2 , Panel: NZ1

    Principal investigator: dr hab. Bartosz Jan Różycki

    Instytut Fizyki PAN

  23. Assessing protein-ligand complexes with ML/DL models trained on molecular dynamics-based descriptors.

    Call: OPUS 20 , Panel: ST4

    Principal investigator: dr hab. Paweł Aleksander Siedlecki

    Instytut Biochemii i Biofizyki PAN

  24. Self-learning systems in the design of compounds modulating GPCR receptors activation.

    Call: OPUS 20 , Panel: NZ2

    Principal investigator: dr hab. Dorota Latek

    Uniwersytet Warszawski, Wydział Chemii

  25. The influence of environment on biomolecular function, structure and interactions.

    Call: SONATA BIS 10 , Panel: ST4

    Principal investigator: dr hab. Piotr Mikołaj Setny

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  26. New 5-HT6 receptor ligands from the group of sulfonamide derivatives of cyclic arylguanidines in the treatment of gliobl...

    Call: PRELUDIUM 19 , Panel: NZ7

    Principal investigator: dr Przemysław Patryk Zaręba

    Politechnika Krakowska im. Tadeusza Kościuszki, Wydział Inżynierii i Technologii Chemicznej

  27. Molecular mechanism underlying the anti-inflammatory action of CB2 receptor agonists in microglia: participation of the ...

    Call: OPUS 19 , Panel: NZ7

    Principal investigator: dr Natalia Eleonora Małek-Chudzik

    Politechnika Wrocławska

  28. Investigation of molecular mechanisms of rapid antidepressant action of NLX-101, a biased agonist of the 5-HT1A receptor...

    Call: OPUS 18 , Panel: NZ7

    Principal investigator: prof. Mariusz Papp

    Instytut Farmakologii PAN

  29. Seeking for CB1 and CB2 receptor ligands among drugs, drug metabolites, and phytochemical compounds

    Call: PRELUDIUM 18 , Panel: NZ7

    Principal investigator: Adam Stasiulewicz

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  30. Molecular mechanisms of interplay between RORγ/RORγT receptors and cyclin-dependent kinase inhibitor (AT7519). Analysis ...

    Call: PRELUDIUM 18 , Panel: NZ7

    Principal investigator: Kaja Urszula Karaś

    Instytut Biologii Medycznej PAN

  31. Studies of the molecular mechanisms associated with HPV and CMV infections involved in the pathogenesis of ovarian cance...

    Call: OPUS 17 , Panel: NZ7

    Principal investigator: dr hab. Edyta Teresa Paradowska

    Instytut Biologii Medycznej PAN

  32. Specific interactions of new antitumor unsymmetrical bisacridines, UAs, with DNA and ABC proteins and their potential to...

    Call: OPUS 17 , Panel: NZ7

    Principal investigator: prof. Zofia Mazerska

    Politechnika Gdańska

  33. Recognition, transport and extraction of salts via modular molecular receptors

    Call: SONATA BIS 8 , Panel: ST5

    Principal investigator: dr hab. Jan Romański

    Uniwersytet Warszawski, Wydział Chemii

  34. Molecular characterisation of novel mutations in the gene encoding the luteinizing hormone/choriogonadotropin receptor (...

    Call: PRELUDIUM 15 , Panel: NZ5

    Principal investigator: dr Kamila Julita Adamczuk

    Uniwersytet Medyczny w Lublinie

  35. Molecular Mechanisms of GABAA Receptor Allosteric Modulation by pH Level.

    Call: PRELUDIUM 15 , Panel: NZ1

    Principal investigator: Michał Adam Michałowski

    Uniwersytet Wrocławski, Wydział Nauk Biologicznych

  36. MOLECULAR DETERMINANTS OF SIGNAL PROPAGATION IN THE DELTA AND MU OPIOID RECEPTORS - IN SEARCH FOR ANALGETICS WITH LESS S...

    Call: PRELUDIUM 14 , Panel: NZ2

    Principal investigator: Tomasz Maciej Stepniewski

    Uniwersytet Warszawski, Wydział Chemii

  37. Novel multi-target ligands of aminergic GPCRs as pharmacological tools to study the pathomechanism of schzophrenia

    Call: OPUS 14 , Panel: NZ7

    Principal investigator: dr hab. Agnieszka Anna Kaczor

    Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

  38. Molecular mechanism of anticancer action of selected NSAIDs as a PPAR gamma receptor agonists in experimental models of ...

    Call: PRELUDIUM 14 , Panel: NZ7

    Principal investigator: Adam Kazberuk

    Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

  39. New receptors for C-reactive protein recognition - generation, characterization and application towards fast differentia...

    Call: SONATA 13 , Panel: ST5

    Principal investigator: dr Katarzyna Szot-Karpińska

    Instytut Chemii Fizycznej Polskiej Akademii Nauk

  40. Multiscale investigations on polymorphism of the beta2-adrenergic receptor: from molecular-scale processes to heart fail...

    Call: OPUS 13 , Panel: NZ7

    Principal investigator: dr hab. Anita Płazińska

    Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

  41. Development of unique molecular probes: low-basicity agonists for the study of 5-HT7 receptor function

    Call: OPUS 13 , Panel: NZ7

    Principal investigator: prof. Andrzej Jacek Bojarski

    Instytut Farmakologii PAN

  42. Designing and application of synthetic receptors for protein hormones

    Call: OPUS 13 , Panel: ST4

    Principal investigator: dr hab. Piyush Sindhu Sharma

    Instytut Chemii Fizycznej Polskiej Akademii Nauk

  43. Molecular modeling of allosteric binding and allosteric-orthosteric coupling in cannabinoid receptor CB1

    Call: PRELUDIUM 12 , Panel: NZ1

    Principal investigator: Jakub Jakub Jakowiecki

    Uniwersytet Warszawski, Wydział Chemii

  44. Development of novel light-controllable azobenzene switches as molecular receptors for selective sensing and transport o...

    Call: SONATA 12 , Panel: ST5

    Principal investigator: dr Kajetan Jerzy Dąbrowa

    Instytut Chemii Organicznej Polska Akademia Nauk

  45. The effect of membrane domains on the G protein-lipid interactions

    Call: OPUS 12 , Panel: NZ1

    Principal investigator: dr Agnieszka Polit

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  46. Molecular identification of signalling pathways activated by receptor kinase CRK5 during senescence and stress response ...

    Call: SONATA 12 , Panel: NZ1

    Principal investigator: dr Paweł Burdiak

    Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Instytut Biologii

  47. Piperazine derivatives as active histamine H3 receptor ligands - molecular modeling, synthesis, pharmacological evaluati...

    Call: PRELUDIUM 12 , Panel: NZ7

    Principal investigator: Katarzyna Anna Szczepańska

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

  48. Study of the hormonal and molecular mechanisms of tumorigenesis in the interstitial tissue of the male gonad

    Call: OPUS 12 , Panel: NZ4

    Principal investigator: prof. Barbara Bilińska

    Uniwersytet Jagielloński, Wydział Biologii

  49. Molecular receptors as a tool for studies of interactions agonist/antagonist of H1 - H4 receptors

    Call: PRELUDIUM 11 , Panel: ST5

    Principal investigator: Małgorzata Ewa Walczak

    Politechnika Łódzka, Wydział Chemiczny

  50. Molecular propellers, bevel gears and sea anemones - dynamically chiral triarylmethyl derivatives as versatile stereoche...

    Call: OPUS 11 , Panel: ST5

    Principal investigator: dr hab. Marcin Grzegorz Kwit

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

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