Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Molecular mechanism of anticancer action of selected NSAIDs as a PPAR gamma receptor agonists in experimental models of breast cancer cells.

2017/27/N/NZ7/02370

Keywords:

PPAR gamma Proline Oxidase Apoptosis NSAID

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

woj. podlaskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Adam Kazberuk 

Number of co-investigators in the project: 2

Call: PRELUDIUM 14 - announced on 2017-09-15

Amount awarded: 205 520 PLN

Project start date (Y-m-d): 2018-08-10

Project end date (Y-m-d): 2021-08-09

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. A novel plausible mechanism of NSAIDs-induced apoptosis in cancer cells: the implication of proline oxidase and peroxisome proliferator-activated receptor
    Authors:
    Kazberuk Adam, Zaręba Ilona, Pałka Jerzy, Surażyński Arkadiusz
    Academic press:
    Pharmacological Reports (rok: 2020, tom: 72, strony: 1152-1160), Wydawca: Springer Nature Switzerland AG
    Status:
    Published
    DOI:
    10.1007/s43440-020-00140-z - link to the publication
  2. NSAIDs Induce Proline Dehydrogenase/Proline Oxidase-Dependent and Independent Apoptosis in MCF7 Breast Cancer Cells
    Authors:
    Adam Kazberuk , Magda Chalecka , Jerzy Palka , Katarzyna Bielawska , Arkadiusz Surazynski
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 3813; 1-18), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23073813. - link to the publication
  3. Nonsteroidal Anti-Inflammatory Drugs as PPARγ Agonists Can Induce PRODH/POX-Dependent Apoptosis in Breast Cancer Cells: New Alternative Pathway in NSAID-Induced Apoptosis
    Authors:
    Adam Kazberuk , Magda Chalecka , Jerzy Palka , Arkadiusz Surazynski
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23(3), strony: 1510; 1-21), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23031510 - link to the publication

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