Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Piperazine derivatives as active histamine H3 receptor ligands - molecular modeling, synthesis, pharmacological evaluation

2016/23/N/NZ7/00469

Keywords:

histamine H3 receptors piperazines selective antagonists/inverse agonists

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Katarzyna Szczepańska 

Number of co-investigators in the project: 3

Call: PRELUDIUM 12 - announced on 2016-09-15

Amount awarded: 141 600 PLN

Project start date (Y-m-d): 2017-09-01

Project end date (Y-m-d): 2021-02-28

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Notebook Dell Inspiron 5400 (5 200 PLN)
  2. Komputer Dell Inspiron 5477 AiO 23.8".

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (2)
  1. N-Substituted piperazine derivatives as potential multitarget agents acting on histamine H 3 receptor and cancer resistance proteins
    Authors:
    Katarzyna Szczepańska, Annamária Kincses, Klaudia Vincze, Ewa Szymańska, Gniewomir Latacz, Kamil J Kuder, Holger Stark, Gabriella Spengler, Jadwiga Handzlik, Katarzyna Kieć-Kononowicz
    Academic press:
    Bioorganic & Medicinal Chemistry Letters (rok: 2020, tom: 30, strony: 127522), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmcl.2020.127522 - link to the publication
  2. Structural modifications and in vitro pharmacological evaluation of 4-pyridylpiperazine derivatives as an active and selective histamine H3 receptor ligands
    Authors:
    Katarzyna Szczepańska, Tadeusz Karcz, Agata Siwek, Kamil J. Kuder, Gniewomir Latacz, Marek Bednarski, Małgorzata Szafarz, Stefanie Hagenow, Annamaria Lubelska, Agnieszka Olejarz-Maciej, Michał Sobolewski, Kamil Mika, Magdalena Kotańska, Holger Stark, Katarzyna Kieć-Kononowicz
    Academic press:
    Bioorganic Chemistry (rok: 2019, tom: 91, strony: 103071), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2019.103071 - link to the publication
  3. KSK19 – novel histamine H3 receptor ligand reduces body weight in diet induced obese mice
    Authors:
    Magdalena Kotańska, Kamil Mika, Karolina Reguła, Katarzyna Szczepańska, Małgorzata Szafarz, Marek Bednarski, Agnieszka Olejarz-Maciej, Katarzyna Nowak, Gniewomir Latacz, Szczepan Mogilski, Kamil J. Kuder, Katarzyna Kieć-Kononowicz, Jacek Sapa
    Academic press:
    Biochemical Pharmacology (rok: 2019, tom: 168, strony: 193-203), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bcp.2019.07.006 - link to the publication
  4. Dual-targeting Approach on Histamine H3 and Sigma-1 Receptor Ligands as Promising Pharmacological Tools in the Treatment of CNS-linked Disorders
    Authors:
    Katarzyna Szczepańska, Kamil J. Kuder, Katarzyna Kieć-Kononowicz
    Academic press:
    Current Medicinal Chemistry, (rok: 2020, tom: 27, strony: 45313), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/0929867327666200806103144 - link to the publication
  5. Optimization and preclinical evaluation of novel histamine H3 receptor ligands: Acetyl and propionyl phenoxyalkyl piperazine derivatives
    Authors:
    Katarzyna Szczepańska, Tadeusz Karcz, Magdalena Kotańska, Agata Siwek, Kamil J. Kuder, Gniewomir Latacz, Szczepan Mogilski, Stefanie Hagenow, Annamaria Lubelska, Michał Sobolewski, Holger Stark, Katarzyna Kieć-Kononowicz
    Academic press:
    Bioorganic & Medicinal Chemistry (rok: 2018, tom: 26, strony: 6056-6066), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmc.2018.11.010 - link to the publication
  1. NOVEL HISTAMINE H-3 RECEPTOR LIGANDS-EFFECTIVE COMPOUNDS AS POTENTIAL ANTIOBESITY AGENTS
    Authors:
    Kamil Mika, Magdalena Kotańska, Katarzyna Szczepańska, Kamil J. Kuder, Marek Bednarski, Agnieszka Olejarz-Maciej, Małgorzata Szafarz, Krzysztof Pociecha, Agata Siwek, Katarzyna Kieć-Kononowicz
    Conference:
    The European Histamine Research Society 48th Annual Meeting (rok: 2019, ), Wydawca: Springer
    Data:
    konferencja 15-18.05.2019
    Status:
    Published
  2. STRUCTURAL MODIFICATIONS AND PHARMACOLOGICAL EVALUATION OF 4-PYRIDYLPIPERAZINE DERIVATIVES AS ACTIVE AND SELECTIVE HISTAMINE H-3 RECEPTOR LIGANDS
    Authors:
    Katarzyna Szczepanska, Tadeusz Karcz, Kamil J. Kuder, Gniewomir Latacz, Magdalena Kotańska, Stefanie Hagenow, Holger Stark, Katarzyna Kiec-Kononowicz
    Conference:
    The European Histamine Research Society 48th Annual Meeting (rok: 2019, ), Wydawca: Springer
    Data:
    konferencja 15-18.05.2019
    Status:
    Published

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