Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The effect of membrane domains on the G protein-lipid interactions

2016/23/B/NZ1/00530

Keywords:

G proteins G protein coupled receptors protein-lipid interaction lipid rafts signal transduction molecular recognition

Descriptors:

  • NZ1_2: Biochemistry
  • NZ1_3: Biophysics
  • NZ3_7: Signal transduction

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Agnieszka Polit 

Number of co-investigators in the project: 5

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 755 138 PLN

Project start date (Y-m-d): 2017-08-11

Project end date (Y-m-d): 2022-08-10

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Ekstruder ciśnieniowy (17 000 PLN)
  2. Laser argonowy (29 500 PLN)
  3. Komputer wraz z oprogramowaniem (5 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Gγ and Gα identity dictate a G-protein heterotrimer plasma membrane targeting
    Authors:
    Paweł Mystek, Beata Rysiewicz, Jan Gregrowicz, Marta Dziedzicka-Wasylewska, Agnieszka Polit
    Academic press:
    Cells (rok: 2019, tom: 8, strony: 1246), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells8101246 - link to the publication
  2. The Gαi protein subclass selectivity to the dopamine D2 receptor is also decided by their location at the cell membrane
    Authors:
    Agnieszka Polit, Beata Rysiewicz, Paweł Mystek, Ewa Błasiak, Marta Dziedzicka‑Wasylewska
    Academic press:
    Cell Communication and Signaling (rok: 2020, tom: 18, strony: 45307), Wydawca: BioMed Central Ltd
    Status:
    Published
    DOI:
    10.1186/s12964-020-00685-9 - link to the publication
  3. The polybasic region in Gαi proteins relevant or not? Insights from Gαi3 research
    Authors:
    Beata Rysiewicz, Ewa Błasiak, Marta Dziedzicka-Wasylewska, Agnieszka Polit
    Academic press:
    Cellular Signalling (rok: 2023, tom: brak, strony: brak), Wydawca: Elsevier
    Status:
    Submitted
    DOI:
    brak - link to the publication
  4. Beyond the G protein α subunit: investigating the functional impact of other components of the Gαi3 heterotrimers
    Authors:
    Beata Rysiewicz, Ewa Błasiak, Paweł Mystek, Marta Dziedzicka‑Wasylewska, Agnieszka Polit
    Academic press:
    Cell Communication and Signaling (rok: 2023, tom: 1,06875, strony: 45311), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12964-023-01307-w - link to the publication
  5. Every detail matters. That is, how the interaction between Gα proteins and membrane affects their function
    Authors:
    Agnieszka Polit, Paweł Mystek, Ewa Błasiak
    Academic press:
    Membranes (rok: 2021, tom: 11, strony: 45312), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/membranes11030222 - link to the publication

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