Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Development of unique molecular probes: low-basicity agonists for the study of 5-HT7 receptor function

2017/25/B/NZ7/02929

Keywords:

5-HT7 receptor low-basicity ligands 5-HT7R selective agonists electophysiological tools

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ4_7: Neurophysiology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Andrzej Bojarski 

Number of co-investigators in the project: 14

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 557 580 PLN

Project start date (Y-m-d): 2018-01-19

Project end date (Y-m-d): 2023-01-18

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Mikromanipulator 2x (55 000 PLN)
  2. Sprężarka powietrza z osuszaczem (11 000 PLN)
  3. mieszadło magnetyczne (4 000 PLN)
  4. zautomatyzowany aparat do flash chromatografii z detektorem UV i ELSD (200 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. Fluorinated indole-imidazole conjugates: Selective orally bioavailable 5-HT7 receptor low-basicity agonists, potential neuropathic painkillers
    Authors:
    Hogendorf A. S., Hogendorf A., Popiolek-Barczyk K., Ciechanowska A., Mika J., Satala G., Walczak M., Latacz G., Handzlik J., Kiec-Kononowicz K., Ponimaskin E., Schade S., Zeug A., Bijata M., Kubicki M., Kurczab R., Lenda T., Staron J., Bugno R., Duszynska B., Pilarski B., Bojarski A. J.
    Academic press:
    Eur. J. Med. Chem. (rok: 2019, tom: 170, strony: 261-275), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2019.03.017 - link to the publication
  2. Search for a 5-CT alternative. In vitro and in vivo evaluation of novel pharmacological tools: 3-(1-alkyl-1H-imidazol-5-yl)-1H-indole-5-carboxamides, low-basicity 5-HT7 receptor agonists
    Authors:
    Gniewomir Latacz, Adam S. Hogendorf, Agata Hogendorf, Annamaria Lubelska, Joanna M. Wierońska, Monika Woźniak, Paulina Cieślik, Katarzyna Kieć-Kononowicz, Jadwiga Handzlik, Andrzej J. Bojarski
    Academic press:
    MedChemComm (rok: 2018, tom: 9, strony: 1882-1890), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c8md00313k - link to the publication
  3. N–Skatyltryptamines—Dual 5–HT6R/D2R Ligands with Antipsychotic and Procognitive Potential
    Authors:
    Agata Hogendorf, Adam S. Hogendorf, Rafał Kurczab, Grzegorz Satała, Bernadeta Szewczyk, Paulina Cieślik, Gniewomir Latacz, Jadwiga Handzlik, Tomasz Lenda, Katarzyna Kaczorowska, Jakub Staroń, Ryszard Bugno, Beata Duszyńska, Andrzej J. Bojarski
    Academic press:
    Molecules (rok: 2021, tom: 26, strony: 4605), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules26154605 - link to the publication

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