Projects funded by the NCN

Modulation of protein interaction networks as a new therapeutic target in the treatment of hereditary retinal dystrophie...

Call: SONATA 19 , Panel: NZ5

Principal investigator: dr Xiaonan Liu

Śląski Uniwersytet Medyczny w Katowicach, Wydział Nauk Medycznych w Katowicach

Evaluation of the therapeutic potential of synthetic miRNA-223-3p analog in a rat model of severe asthma

Call: SONATA 19 , Panel: NZ4

Principal investigator: dr Wojciech Jerzy Langwiński

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Actin cytoskeleton disorders as a pro-survival signaling activator and a therapeutic biomarker in Diffuse Large B-cell L...

Call: SONATA BIS 13 , Panel: NZ5

Principal investigator: dr Patryk Górniak

Instytut Hematologii i Transfuzjologii

Targeting IGH enhancer RNAs as a therapeutic approach in B-cell lymphoma

Call: SONATA BIS 13 , Panel: NZ1

Principal investigator: dr hab. Agnieszka Dzikiewicz-Krawczyk

Instytut Genetyki Człowieka Polskiej Akademii Nauk

Design and Development of Serine Hydroxymethyltransferase-2 (SHMT2) Inhibitors Blocking Tumor Growth

Call: SONATA BIS 13 , Panel: NZ7

Principal investigator: dr hab. Miłosz Ruszkowski

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Exploring the Therapeutic Effects of Human Adipose Tissue Mesenchymal Stem Cell (HATMSC) line Secretome on Chronic Skin ...

Call: SONATA BIS 13 , Panel: NZ3

Principal investigator: dr Honorata Kraśkiewicz

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

The inhibition of NMDAR and TRPM4 coupling - a hope for novel therapeutic target for the treatment of the ischemic brain...

Call: SONATA BIS 13 , Panel: NZ7

Principal investigator: dr Bartosz Sebastian Pomierny

Uniwersytet Jagielloński, Collegium Medicum

Three to tango - biomaterials with therapeutic and regenerative multifunctionality

Call: SONATA BIS 13 , Panel: ST11

Principal investigator: dr Marzena Krystyna Fandzloch

Instytut Niskich Temperatur i Badań Strukturalnych im. Włodzimierza Trzebiatowskiego Polskiej Akademii Nauk

Prioritizing diagnostics and therapeutics of human prion diseases through integrative omics

Call: WEAVE-UNISONO , Panel: NZ2

Principal investigator: prof. Beata Sikorska

Uniwersytet Medyczny w Łodzi

Extensive analysis of the immunological profile of pediatric patients with acute lymphoblastic leukemia in order to iden...

Call: PRELUDIUM 22 , Panel: NZ5

Principal investigator: Anna Krętowska-Grunwald

Uniwersytet Medyczny w Białymstoku

Cuproptosis, a novel pathway of regulated cell death as a therapeutic target in treatment-naïve and targeted therapy-res...

Call: OPUS 25 , Panel: NZ5

Principal investigator: dr hab. Mariusz Łukasz Hartman

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Bigels with controlled release of hydrophilic and hydrophobic therapeutic compounds as potential dressings in the treatm...

Call: OPUS 25 , Panel: ST11

Principal investigator: dr hab. Monika Gosecka

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

Designing Active Inhibitors of SARS-CoV-2 Methyltransferases

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Alex Jun Matsuda

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Targeting undruggable proteins involved in tumorigenesis – developing and characterization of advanced nanoplatform for ...

Call: OPUS 25 , Panel: NZ6

Principal investigator: dr hab. Monika Bzowska

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Bitechnologii

Selective PPARγ modulation by amorfrutin B as a novel therapeutic approach to chemotherapy-induced damage to mammalian b...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Bernadeta Angelika Pietrzak-Wawrzyńska

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Therapeutic self-understanding

Call: SONATA 18 , Panel: HS1

Principal investigator: dr Jędrzej Piotr Grodniewicz

Uniwersytet Jagielloński, Centrum Kopernika Badań Interdyscyplinarnych Uniwersytetu Jagiellońskiego

Specific immune signatures of T cells as biomarkers of the post-COVID Syndrome and predictors of long-term health dysfun...

Call: PRELUDIUM BIS 4 , Panel: NZ6

Principal investigator: dr hab. Katarzyna Piwocka

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

Molecular insights into hypoxic tumors – for development of targeted cancer therapeutics

Call: POLONEZ BIS 3 , Panel: NZ5

Principal investigator: dr Marco Deiana

Politechnika Wrocławska

Computational deciphering of pro-ferroptotic cell death protein machinery as a fundamental step in the search for therap...

Call: SONATA BIS 12 , Panel: ST4

Principal investigator: dr hab. Karolina Anna Mikulska-Rumińska

Uniwersytet Mikołaja Kopernika w Toruniu, Wydział Fizyki, Astronomii i Informatyki Stosowanej

Studies on the post-receptor mechanisms of TSPO in search of a novel therapeutic target of metabolic syndrome

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: dr Łukasz Kurach

Uniwersytet Medyczny w Lublinie

The role of simultaneous and individual modulation of μ-opioid, sigma-1 and histamine H3 receptors as a new therapeutic ...

Call: OPUS 23 , Panel: NZ7

Principal investigator: dr Katarzyna Anna Szczepańska

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Mechanisms and therapeutic potential of SGLT2/SGLT1 and NHE-1 inhibition in a rat model of heart failure with preserved ...

Call: OPUS 23 , Panel: NZ5

Principal investigator: dr hab. Urszula Mackiewicz

Centrum Medyczne Kształcenia Podyplomowego

Chemical and surgical castration of sex offenders - effective punishment, therapeutic measure or dehumanizing torture? A...

Call: PRELUDIUM 21 , Panel: HS5

Principal investigator: Katarzyna Teresa Jakubczak-Fopke

Uniwersytet Gdański, Wydział Prawa i Administracji

Selective modulation of PPARγ signaling as a new therapeutic strategy for Alzheimer's disease

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: Karolina Barbara Przepiórska-Drońska

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

The evaluation of therapeutic potential of β-caryophyllene in animal schizophrenia model - behavioral and molecular stud...

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: dr Magdalena Białoń

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Targeting of metabolic and transcriptomic cross-talk between leukemic cells and macrophages as a therapeutic strategy in...

Call: OPUS 22 , Panel: NZ5

Principal investigator: dr Baran Natalia

Instytut Hematologii i Transfuzjologii

Mechanisms and consequences of CD19 loss in B-acute lymphoblastic leukaemia patients relapsing after CD19-CAR-T cell the...

Call: PRELUDIUM BIS 3 , Panel: NZ5

Principal investigator: prof. Przemysław Juszczyński

Instytut Hematologii i Transfuzjologii

Targeting UDP-glucose and P2Y14 receptor interaction for therapeutic modulation of inflammatory lung diseases

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Tadeusz Piotr Karcz

Uniwersytet Jagielloński, Collegium Medicum

Role of RelA(p65) and cRel phosphorylations and their kinases in the biology of Diffuse-large B-cell lymphoma and Hodgki...

Call: OPUS 22 , Panel: NZ5

Principal investigator: dr Maciej Stefan Szydłowski

Instytut Hematologii i Transfuzjologii

Inhibition of protein disulfide isomerases as a strategy for reduction of prothrombotic state in atherosclerosis; therap...

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Kamil Przyborowski

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

Targeting of HSF1 as a therapeutic approach to inhibit the progression of hormone-dependent breast cancer.

Call: OPUS 22 , Panel: NZ5

Principal investigator: dr Natalia Vydra

Narodowy lnstytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy lnstytut Badawczy, Oddział w Gliwicach

New immunomodulators of BTLA-HVEM complex as potential therapeutics in systemic lupus erythematosus

Call: OPUS 22 , Panel: NZ7

Principal investigator: dr hab. Anna Wardowska

Gdański Uniwersytet Medyczny, Wydział Lekarski

Identification and therapeutic targeting of the mRNA splicing alteration mechanisms driven by gain-of-function TP53 muta...

Call: SONATA 17 , Panel: NZ5

Principal investigator: dr Magdalena Oroń

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

Searching for new therapeutic targets in polyglutamine diseases

Call: OPUS 22 , Panel: NZ2

Principal investigator: dr hab. Marta Olejniczak

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

P-stereodefined phosphorothioate analogs of morpholino" oligonucleotides (sTMO) as a new model of therapeutic nucleic ac...

Call: SONATA 17 , Panel: ST4

Principal investigator: dr Katarzyna Jastrzębska

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

Non-provitamin A carotenoids as a novel therapeutic strategy in intestinal failure associated liver disease (IFALD)

Call: PRELUDIUM BIS 3 , Panel: NZ7

Principal investigator: dr hab. Maciej Jan Stawny

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

efFect of nanoscale, three dimensIonal arrangement of proteins on biological and Therapeutic activity (FIT)

Call: OPUS 22 (LAP) , Panel: NZ1

Principal investigator: dr Antonina Naskalska

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

The roles and therapeutic potential of distinct dystrophin and utrophin isoforms in the central and peripheral nervous s...

Call: OPUS 22 , Panel: NZ5

Principal investigator: dr hab. Patryk Konieczny

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

Proline metabolism as a novel therapeutic target for diseases associated with mitochondrial dysfunction.

Call: SONATA BIS 11 , Panel: NZ3

Principal investigator: dr Karolina Szczepanowska

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

Investigation of the MLK4 biology in breast cancer and search for new therapeutic strategies using innovative PROTAC com...

Call: SONATA BIS 11 , Panel: NZ5

Principal investigator: dr Anna Agnieszka Marusiak

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

Role of Mcpip1 in biliary pathobiology: new potential therapeutic opportunities

Call: SONATA BIS 11 , Panel: NZ5

Principal investigator: dr Jerzy Kotlinowski

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Improvement of therapeutic safety of parenteral nutrition in cancer patients - the interplay between supportive drugs an...

Call: PRELUDIUM 20 , Panel: NZ5

Principal investigator: Szymon Tomczak

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

New type of analogs and conjugates of folic acid with potential therapeutic applicaton in treatment of hormone-dependent...

Call: PRELUDIUM 20 , Panel: NZ7

Principal investigator: Olga Ciupak

Politechnika Gdańska, Wydział Chemiczny

Assessment of SARS-CoV-2 infection in patients with chronic lymphocytic leukemia depending on indicators of immune disor...

Call: OPUS 21 , Panel: NZ6

Principal investigator: prof. Ewelina Pia Grywalska

Uniwersytet Medyczny w Lublinie

Effect of SSR 504734, a selective glycine transporter type 1 inhibitor, on seizure activity and therapeutic efficacy of ...

Call: OPUS 21 , Panel: NZ7

Principal investigator: prof. Piotr Wiktor Wlaź

Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Biologii i Biotechnologii

Investigation of a new therapeutic strategy to lower mutant protein in SCA3 / MJD

Call: OPUS 21 , Panel: NZ2

Principal investigator: prof. Maciej Figiel

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Verification of personalized therapeutic strategy based on Integrated Stress Response inhibition for myeloid neoplasms w...

Call: OPUS 21 , Panel: NZ5

Principal investigator: dr hab. Katarzyna Piwocka

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

Psychedelics as Therapeutic Candidates in Neurodegenerative Disorders Treatment– a Study in Spinocerebellar Ataxia Type ...

Call: SONATINA 5 , Panel: NZ4

Principal investigator: dr Urszula Joanna Kozłowska

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Spectroelectrochemistry of Alzheimer's disease - a study of a new potential therapeutic molecule

Call: SONATINA 5 , Panel: ST4

Principal investigator: dr Magdalena Zofia Wiloch

Instytut Chemii Fizycznej Polskiej Akademii Nauk

Selective activation of non-nuclear Estrogen Receptor signaling with PaPE-1 as a novel therapeutic approach for sporadic...

Call: OPUS 20 , Panel: NZ7

Principal investigator: prof. Małgorzata Kajta

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk