Improving the healing potential of therapeutic proteins by planned, specific modifiactions on the example of bacteriolytic lysins.
2019/35/N/NZ6/02564
Keywords
Descriptors
- NZ6_005: Wirusologia
- NZ6_004: Bakteriologia
- NZ1_001: Biologia molekularna
Panel
NZ6 – Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology
Host institution
Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk
Voivodeship: dolnośląskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 2
Call
PRELUDIUM 18 – announced on 2019-09-16
- Amount awarded
- 140 000 PLN
- Project start date
- 2020-06-25
- Project end date
- 2024-06-24
- Project duration
- 48 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (3)
-
DNA Dye Sytox Green in Detection of Bacteriolytic Activity: High Speed, Precision and Sensitivity Demonstrated With Endolysins
- Authors:
- Marek Harhala, Katarzyna Gembara, Paulina Miernikiewicz, Barbara Owczarek, Zuzanna Kaźmierczak, Joanna Majewska, Daniel C. Nelson and Krystyna Dąbrowska
- Academic press:
- Frontiers in Microbiology (year: 2021, volume: 12, pages: 3129-3138), Publisher: Frontiers in Microbiology
- Status:
- Published
- DOI:
- 10.3389/fmicb.2021.752282 – link to the publication
-
Physicochemical and Proteolytic Barriers Limiting Activity of Cpl-1 and Pal Endolysins in Human Circulation
- Authors:
- Marek Adam Harhala, Katarzyna Gembara, Izabela Rybicka, Zuzana Maria Kaźmierczak, Paulina Miernikiewicz, Krystyna Dąbrowska
- Academic press:
- Current Issues in Molecular Biology (year: 2026, volume: 48, pages: 231-253), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/cimb48020231 – link to the publication
-
Immunogenic epitope scanning in bacteriolytic enzymes Pal and Cpl-1 and engineering Pal to escape antibody responses
- Authors:
- Marek Adam Harhala, Katarzyna Gembara, Izabela Rybicka, Zuzanna Maria Kaz´mierczak, Paulina Miernikiewicz, Joanna Marta Majewska, Wiktoria Budziar , Anna Nasulewicz-Goldeman, Daniel C. Nelson, Barbara Owczarek, Krystyna Dąbrowska
- Academic press:
- Frontiers in Immunology (year: 2023, volume: 14, pages: 46035), Publisher: Frontiers Media S.A.
- Status:
- Published
- DOI:
- 10.3389/fimmu.2023.1075774 – link to the publication