Projects funded by the NCN
P-stereodefined phosphorothioate analogs of morpholino" oligonucleotides (sTMO) as a new model of therapeutic nucleic acids: synthesis, structure, physicochemical and biological properties.
2021/43/D/ST4/02433
Keywords:
antisense oligonucleotides morpholino analogs P-stereodefined phosphorothioate analogs oxathiaphospholane approach thermodynamic stability
Descriptors:
- ST4_009:
- ST4_008:
Panel:
ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development
Host institution :
Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk
woj. łódzkie
Principal investigator (from the host institution):
Number of co-investigators in the project: 4
Call: SONATA 17 - announced on 2021-09-15
Amount awarded: 1 223 800 PLN
Project start date (Y-m-d): 2022-07-11
Project end date (Y-m-d): 2025-07-10
Project duration:: 36 months (the same as in the proposal)
Project status: Project completed
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (2)
- P-Stereodefined morpholino dinucleoside 3′,5′-phosphorothioatesAuthors:Jastrzębska Katarzyna, Antończyk Patrycja, Dolot RafałAcademic press:Organic & Biomolecular Chemistry (rok: 2024, tom: 22, strony: 8737-8742), Wydawca: The Royal Society of ChemistryStatus:PublishedDOI:10.1039/D4OB01437E - link to the publication
- An efficient alternative to DBU in the oxathiaphospholane (OTP) method for the solid phase synthesis of P-stereodefined phosphorothioate analogsAuthors:Jastrzębska KatarzynaAcademic press:RSC Advances (rok: 2024, tom: 14, strony: 21174-21179), Wydawca: The Royal Society of ChemistryStatus:PublishedDOI:10.1039/D4RA02833C - link to the publication