The influence of EGFRvIII structure and its cellular distribution heterogeneity on designing new therapeutic and diagnostic approaches
2019/35/B/NZ3/03577
Keywords
Descriptors
- NZ3_001: Biologia komórki
- NZ1_001: Biologia molekularna
- NZ7_014: Farmacja, farmakoterapia, farmakologia
Panel
NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology
Host institution
Uniwersytet Medyczny w Łodzi, Wydział Lekarski
Voivodeship: łódzkie
Principal investigator (from the host institution)
Number of co-investigators in the project: 6
Call
OPUS 18 – announced on 2019-09-16
- Amount awarded
- 1 608 840 PLN
- Project start date
- 2020-07-27
- Project end date
- 2025-01-26
- Project duration
- 54 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (4)
-
Phenotypical Flexibility of the EGFRvIII-Positive Glioblastoma Cell Line and the Multidirectional Influence of TGFβ and EGF on These Cells-EGFRvIII Appears as a Weak Oncogene
- Authors:
- Aneta Włodarczyk, Cezary Tręda, Adrianna Rutkowska,Dagmara Grot,Weronika Dobrewa Amelia Kierasińska,Marta Węgierska , Tomasz Wasiak , Tadeusz Strózik ,Piotr Rieske Ewelina Stoczyńska-Fidelus
- Academic press:
- International Journal of Molecular Sciences (year: 2022, volume: 23 (20), pages: nie dotyczy), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms232012129 – link to the publication
-
Application and Design of Switches Used in CAR
- Authors:
- Paweł Głowacki, Piotr Rieske
- Academic press:
- Cells (year: 2022, volume: 11(12), pages: nie dotyczy), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/cells11121910 – link to the publication
-
Immunohistochemical detection of EGFRvIII in glioblastoma - Anti-EGFRvIII antibody validation for diagnostic and CAR-T purposes
- Authors:
- Adrianna Rutkowska, Tadeusz Strózik , Krystyna Jędrychowska-Dańska , Alicja Zamerska , Dorota Jesionek-Kupnicka , Tamara Kowalczyk , Waldemar Och , Błażej Szóstak , Cezary Tręda , Aneta Włodarczyk , Amelia Kierasińska-Kałka , Tomasz Wasiak , Damian Ciunowicz Piotr Rieske , Ewelina Stoczyńska-Fidelus
- Academic press:
- Biochem Biophys Res Commun (year: 2023, volume: 685, pages: brak numerów stron), Publisher: Science Direct
- Status:
- Published
- DOI:
- 10.1016/j.bbrc.2023.149133 – link to the publication
-
Increased EGFRvIII Epitope Accessibility after Tyrosine Kinase Inhibitor Treatment of Glioblastoma Cells Creates More Opportunities for Immunotherapy
- Authors:
- Cezary Tręda , Aneta Włodarczyk , Marcin Pacholczyk, Adrianna Rutkowska, Ewelina Stoczyńska-Fidelus, Amelia Kierasińska , Piotr Rieske
- Academic press:
- International Journal of Molecular Sciences (year: 2023, volume: 24(5), pages: nie dotyczy), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms24054350 – link to the publication