Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Improving therapeutic efficacy of anti-CD20 antibodies in precursor B-cell acute lymphoblastic leukemia

2019/35/B/NZ5/01428

Keywords:

acute lymphoblastic leukemia B cell CD20 therapy immunotherapy antibodies

Descriptors:

  • NZ5_007:
  • NZ6_001:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Małgorzata Firczuk 

Number of co-investigators in the project: 9

Call: OPUS 18 - announced on 2019-09-16

Amount awarded: 1 819 368 PLN

Project start date (Y-m-d): 2020-09-29

Project end date (Y-m-d): 2024-09-28

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (2)
  1. Advancements in cancer immunotherapies targeting CD20: from pioneering monoclonal antibodies to chimeric antigen receptor-modified T cells
    Authors:
    Agnieszka Dabkowska, Krzysztof Domka, Malgorzata Firczuk
    Academic press:
    Frontiers in Immunology (rok: 2024, tom: 15, strony: 45674), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fimmu.2024.1363102 - link to the publication
  2. Concomitant inhibition of the thioredoxin system and nonhomologous DNA repair potently sensitizes Philadelphia-positive lymphoid leukemia to tyrosine kinase inhibitors
    Authors:
    Lukasz Komorowski, Agnieszka Dabkowska, Joanna Madzio, Agata Pastorczak, Kacper Szczygiel, Martyna Janowska, Klaudyna Fidyt, Maksymilian Bielecki, Jaromir Hunia, Malgorzata Bajor, Tomasz Stoklosa, Magdalena Winiarska, Elzbieta Patkowska, Malgorzata Firczuk
    Academic press:
    Hemasphere (rok: 2024, tom: 8, strony: 45670), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/hem3.56 - link to the publication
  3. Old and new targets for immunotherapy of B cell acute lymphoblastic leukemia
    Authors:
    Małgorzata Firczuk
    Academic press:
    Acta Haematologica Polonica (rok: 2021, tom: 52, strony: 291-299), Wydawca: Via Medica
    Status:
    Published
    DOI:
    10.5603/AHP.2021.0056 - link to the publication
  4. Mechanisms of Immune Evasion in Acute Lymphoblastic Leukemia
    Authors:
    Pastorczak A, Domka K, Fidyt K, Poprzeczko M, Firczuk M
    Academic press:
    Cancers (rok: 2021, tom: 13(7):1536, strony: 45682), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13071536 - link to the publication
  5. Asciminib stands out as the superior tyrosine kinase inhibitor to combine with anti-CD20 monoclonal antibodies for the treatment of CD20+ Philadelphia-positive B-cell precursor acute lymphoblastic leukemia in preclinical models
    Authors:
    Krzysztof Domka Agnieszka Dąbkowska Martyna Janowska Zuzanna Urbańska Agata Pastorczak Magdalena Winiarska Klaudyna Fidyt Mieszko Lachota Elżbieta Patkowska Łukasz Sędek Bartosz Perkowski Jaromir Hunia Justyna Jakubowska Beata Krzymieniewska Ewa Lech-Marańda Wojciech Młynarski Tomasz Szczepański Małgorzata Firczuk
    Academic press:
    Haematologica (rok: 2024, tom: 11, strony: 3520-3532), Wydawca: Fondazione Adolfo Ferrata ed Edoardo Storti
    Status:
    Published
    DOI:
    10.3324/haematol.2023.284853 - link to the publication
  1. Optimizing the therapeutic potential of tyrosine kinase inhibitors in chemo-immunotherapy of B-cell acute lymphoblastic leukemia involving rituximab
    Authors:
    Krzysztof Domka; Martyna Poprzeczko; Zuzanna Urbanska; Lukasz Komorowski; Agata Pastorczak; Klaudyna Fidyt; Agnieszka Dabkowska; Mieszko Lachota; Magdalena Winiarska;Karolina Siudakowska; Elzbieta Patkowska; Łukasz Sędek; Bartosz Perkowski; Beata Krzymieniewska; Malgorzata Firczuk
    Conference:
    POSTER PRESENTATIONS - PROFFERED ABSTRACTS (rok: 2022, tom: American Association for Cancer Research Annual Meeting 2022, Nowy Orlean, Luizjana, USA, strony: 3324), Wydawca: AACR
    Data:
    konferencja 8-13.04.2022
    Status:
    Published
    DOI:
    10.1158/1538-7445.AM2022-3324 - link to the publication
  2. Optimizing the therapeutic potential of tyrosine kinase inhibitors in chemo-immunotherapy of B-cell acute lymphoblastic leukemia involving rituximab
    Authors:
    Krzysztof Domka; Martyna Poprzeczko; Zuzanna Urbanska; Lukasz Komorowski; Agata Pastorczak; Klaudyna Fidyt; Agnieszka Dabkowska; Mieszko Lachota; Magdalena Winiarska;Karolina Siudakowska; Elzbieta Patkowska; Łukasz Sędek; Bartosz Perkowski; Beata Krzymieniewska; Malgorzata Firczuk
    Conference:
    POSTER PRESENTATIONS - PROFFERED ABSTRACTS (rok: 2022, tom: American Association for Cancer Research Annual Meeting 2022, Nowy Orlean, Luizjana, USA, strony: 3324), Wydawca: AACR
    Data:
    konferencja 8-13.04.2022
    Status:
    Published
    DOI:
    10.1158/1538-7445.AM2022-3324 - link to the publication

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