Antisense oligonucleotides and their nanostructures conjugated with boron clusters; physico-chemical and biological characterization - attempts to estimate the potential of compounds for the use in BNCT therapy.
2020/36/T/ST4/00485
Keywords
Descriptors
- ST4_009: Chemia biologiczna
- ST4_008: Chemia organiczna
Panel
ST4 – Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development
Host institution
Centrum Badań Molekularnych i Makromolekularnych PAN
Voivodeship: łódzkie
Principal investigator (from the host institution)
Number of co-investigators in the project: 1
Call
ETIUDA 8 – announced on 2019-12-16
- Amount awarded
- 138 168 PLN
- Project start date
- 2020-10-01
- Project end date
- 2022-11-23
- Project duration
- 26 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (4)
-
Composites of Nucleic Acids and Boron Clusters (C2B10H12) as Functional Nanoparticles for Downregulation of EGFR Oncogene in Cancer Cells
- Authors:
- Kaniowski D, Ebenryter-Olbińska K, Kulik K, Suwara J, Cypryk W, Jakóbik-Kolon A, Leśnikowski Z, Nawrot B.
- Academic press:
- International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 4863), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms22094863 – link to the publication
-
Boron Clusters as Enhancers of RNase H Activity in the Smart Strategy of Gene Silencing by Antisense Oligonucleotides
- Authors:
- Kaniowski, D.; Kulik, K.; Suwara, J.; Ebenryter-Olbińska, K.; Nawrot, B.
- Academic press:
- International Journal of Molecular Sciences (year: 2022, volume: 23, pages: 12190), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms232012190 – link to the publication
-
EGFR-Targeted Cellular Delivery of Therapeutic Nucleic Acids Mediated by Boron Clusters
- Authors:
- Kaniowski, D.; Suwara, J.; Ebenryter-Olbińska, K.; Jakóbik-Kolon, A.; Nawrot, B.
- Academic press:
- International Journal of Molecular Sciences (year: 2022, volume: 23, pages: 14793), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms232314793 – link to the publication
-
Molecular Mechanisms of Specific Cellular DNA Damage Response and Repair Induced by the Mixed Radiation Field During Boron Neutron Capture Therapy
- Authors:
- Maliszewska-Olejniczak K, Kaniowski D, Araszkiewicz M, Tymińska K, Korgul A.
- Academic press:
- Frontiers in Oncology (year: 2021, volume: 11, pages: 676575), Publisher: Frontiers
- Status:
- Published
- DOI:
- 10.3389/fonc.2021.676575 – link to the publication