Projects funded by the NCN

Dual-Target Compounds Modulating EAAT2 and Kv7.2/3 Channels: A Rational Strategy Toward Novel Antiseizure and Antinocice...

Call: OPUS 29 , Panel: NZ7

Principal investigator: dr Michał Andrzej Abram

Uniwersytet Jagielloński

Cholesin and its receptor as novel therapeutic and diagnostic targets in metabolic disorders

Call: OPUS 29 , Panel: NZ7

Principal investigator: prof. Wojciech Fendler

Uniwersytet Medyczny w Łodzi

Positioning the aryl hydrocarbon receptor (AhR) as a new target for pharmacotherapy of sporadic Alzheimer disease: verif...

Call: OPUS 28 , Panel: NZ7

Principal investigator: prof. Małgorzata Kajta

Instytut Farmakologii PAN

Investigation of the mechanism of enhanced liposome delivery to tumors and its application for dual target immunotherapy

Call: OPUS 28 , Panel: NZ7

Principal investigator: dr hab. Tomasz Piotr Rygiel

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Modified nucleotide residues as potential tool to increase aptamer - target protein interaction

Call: SONATA 20 , Panel: NZ7

Principal investigator: dr Weronika Paulina Kotkowiak

Instytut Chemii Bioorganicznej PAN

Disruption of the posttranslational activation of the translation factor EF-P as a new target for antimicrobial agents.

Call: OPUS 27 , Panel: NZ7

Principal investigator: dr Piotr Wilk

Uniwersytet Jagielloński

Two-body currents in the electron and neutrino scattering off few-nucleon targets

Call: IMPRESS-U , Panel: ST2

Principal investigator: prof. Jacek Golak

Uniwersytet Jagielloński

The inhibition of NMDAR and TRPM4 coupling - a hope for novel therapeutic target for the treatment of the ischemic brain...

Call: SONATA BIS 13 , Panel: NZ7

Principal investigator: dr Bartosz Sebastian Pomierny

Uniwersytet Jagielloński, Collegium Medicum

Directed screening and evaluation of novel bactericidal compounds active againsttubercle bacilli and Mycobacterium absce...

Call: OPUS 25 , Panel: NZ7

Principal investigator: prof. Jarosław Dziadek

Instytut Biologii Medycznej PAN

The Role of the Mitochondrial Unfolded Protein Response (UPRmt) in Endothelial Function: a Possible Novel Target for the...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Sylwester Tycjan Mosiołek

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

Gaining control on XBP1s signaling as a starting point for novel cancer therapies

Call: OPUS 24 , Panel: NZ7

Principal investigator: prof. Rafał Artur Bartoszewski

Uniwersytet Wrocławski, Wydział Biotechnologii

Studies on the post-receptor mechanisms of TSPO in search of a novel therapeutic target of metabolic syndrome

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: dr Łukasz Kurach

Uniwersytet Medyczny w Lublinie

Brain cytochrome P450 as a new target for the treatment of neurological and psychiatric diseases. Studies with human neu...

Call: OPUS 23 , Panel: NZ7

Principal investigator: prof. Władysława Anna Daniel

Instytut Farmakologii PAN

The role of simultaneous and individual modulation of μ-opioid, sigma-1 and histamine H3 receptors as a new therapeutic ...

Call: OPUS 23 , Panel: NZ7

Principal investigator: dr Katarzyna Anna Szczepańska

Instytut Farmakologii PAN

Omics-guided engineering of a secretory pathway for enhanced synthesis of secretory proteins in Yarrowia lipolytica - fu...

Call: PRELUDIUM 21 , Panel: NZ9

Principal investigator: dr Paulina Anna Korpys-Woźniak

Uniwersytet Przyrodniczy w Poznaniu, Wydział Nauk o Żywności i Żywieniu

Novel broad-spectrum central nervous system active substances: optimization of their multi-target profile

Call: OPUS 22 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Anna Kaczor

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

Studies on anti-inflammatory properties of GPR18 ligands and their involvement in modulation of microglia phenotypes – a...

Call: OPUS 22 , Panel: NZ7

Principal investigator: dr hab. Dorota Justyna Łażewska

Uniwersytet Jagielloński, Collegium Medicum

Research of multifunctional compounds targeting neuroinflammation and cholinergic deficit in Alzheimer's disease

Call: OPUS 22 (LAP) , Panel: NZ7

Principal investigator: prof. Kinga Aleksandra Sałat

Uniwersytet Jagielloński, Collegium Medicum

In search for molecular targets to overcome doxorubicin resistance in triple-negative breast cancer with the use of inno...

Call: PRELUDIUM 20 , Panel: NZ7

Principal investigator: Anna Karolina Pogorzelska

Narodowy Instytut Leków

Aging-associated, specific pathomechanisms of endothelial dysfunction in sepsis: pathway analysis and experimental thera...

Call: WEAVE-UNISONO , Panel: NZ7

Principal investigator: prof. Stefan Karol Chłopicki

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

Enzymes of the L-methionine biosynthetic pathway as novel moleculartargets for antifungal chemotherapy

Call: OPUS 20 , Panel: NZ7

Principal investigator: dr hab. Iwona Aniela Gabriel

Politechnika Gdańska, Wydział Chemiczny

The study on the molecular mechanisms of cytotoxic activity of new compounds ZOT5-1-Me and ZOT5-1-Et in an experimental ...

Call: SONATA 16 , Panel: NZ7

Principal investigator: dr Paulina Anna Tokarz

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Identification of surface proteins as alternate targets for CAR-T therapy against CD19-negative tumors.

Call: PRELUDIUM BIS 2 , Panel: NZ6

Principal investigator: dr hab. Magdalena Hanna Winiarska

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Drug repurposing to target p53 protein family for improved therapy in the relapsed TP53 and EGFR mutated lung cancer

Call: OPUS 20 , Panel: NZ7

Principal investigator: dr hab. Alicja Elżbieta Chrzanowska

Warszawski Uniwersytet Medyczny

DNA polymerase θ as a novel therapeutic target in personalized anticancer therapy

Call: OPUS 19 , Panel: NZ7

Principal investigator: prof. Tomasz Adam Śliwiński

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

New multifunctional drug-like ligands focusing on molecular targets associated with the symptoms and causes of Alzheimer...

Call: PRELUDIUM 19 , Panel: NZ7

Principal investigator: Anna Marta Pasieka

Uniwersytet Jagielloński, Collegium Medicum

Novel approach in the search for asthma and COPD therapies - computer aided design of multi-target-directed ligands bloc...

Call: PRELUDIUM 19 , Panel: NZ7

Principal investigator: Alicja Aleksandra Gawalska

Uniwersytet Jagielloński, Collegium Medicum

Physical exercise as a natural mechanism inducing neuroregeneration. Search for the new protein markers and therapeutic ...

Call: OPUS 18 , Panel: NZ7

Principal investigator: dr hab. Katarzyna Zofia Kuter-Nowak

Instytut Farmakologii PAN

Gankyrin protein as a new potential therapeutic target in multiple myeloma

Call: OPUS 18 , Panel: NZ5

Principal investigator: dr hab. Irena Misiewicz-Krzemińska

Instytut Hematologii i Transfuzjologii

Biased multi-target ligands as tools for activity pattern analysis of G protein-coupled receptors in cancer cells

Call: SONATA 14 , Panel: NZ7

Principal investigator: dr Artur Wnorowski

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej

The effect of thiol redox regulators on seed quality and the aging process

Call: OPUS 16 , Panel: NZ9

Principal investigator: dr hab. Ewelina Antonina Ratajczak

Instytut Dendrologii PAN

Determination of targets for peptidylarginine deiminase type 4 (PAD4) among complement system proteins and assessment of...

Call: HARMONIA 10 , Panel: NZ1

Principal investigator: dr Ewa Izabela Bielecka

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Opioid-induced analgesia and hyperalgesia in neuropathic pain - mechanisms and druggable targets

Call: OPUS 15 , Panel: NZ7

Principal investigator: prof. Barbara Elżbieta Przewłocka

Instytut Farmakologii PAN

Novel multi-target ligands of aminergic GPCRs as pharmacological tools to study the pathomechanism of schzophrenia

Call: OPUS 14 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Anna Kaczor

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

The enzymes of RNA metabolism, PAP I and PNPase, as targets for new antimycobacterial drugs and their functional charact...

Call: OPUS 13 , Panel: NZ7

Principal investigator: prof. Jarosław Dziadek

Instytut Biologii Medycznej PAN

Peroxiredoxins as potential therapeutic targets in glioblastoma.

Call: OPUS 13 , Panel: NZ7

Principal investigator: dr hab. Monika Paulina Szeliga

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Novel 2,4-disubstituted pyridine derivatives - synthesis, antimycobacterial activity in vitro, pharmacophore model, mole...

Call: OPUS 13 , Panel: NZ7

Principal investigator: dr hab. Katarzyna Małgorzata Gobis

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

New mulitple target-directed ligands - A1/A2A adenosine receptors antagonists and monoamine oxidase B inhibitors - searc...

Call: PRELUDIUM 12 , Panel: NZ7

Principal investigator: Michał Karol Załuski

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Identification of Mycobacterium tuberculosis ligands binding human serum amyloid A (SAA) and biological function of tube...

Call: OPUS 12 , Panel: NZ7

Principal investigator: dr hab. Bożena Renata Dziadek

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Determination of the mechanisms and potential targets for neuropathic pain therapy by investigating pharmacological inte...

Call: PRELUDIUM 12 , Panel: NZ7

Principal investigator: Anna Piotrowska-Murzyn

Instytut Farmakologii PAN

Novel multi-target directed ligands combining cholinesterase inhibition and 5-HT6 antagonism - design, synthesis and pha...

Call: SONATA 12 , Panel: NZ7

Principal investigator: dr hab. Anna Karolina Więckowska

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Modeling of structure of gamma-aminobutyric acid transporters as an essential biological and therapeutic target

Call: SONATA 12 , Panel: NZ7

Principal investigator: dr hab. Marek Wojciech Bajda

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

New 2(5H)-furanone derivatives with tailored hydrophobicity of substitutents - synthesis, molecular targets, mechanism o...

Call: OPUS 11 , Panel: NZ7

Principal investigator: prof. Krzysztof Zdzisław Walczak

Politechnika Śląska, Wydział Chemiczny

Modulation of fatty acid binding protein 4 and dietary fatty acid intake as a potential therapeutic target in the manage...

Call: PRELUDIUM 11 , Panel: NZ5

Principal investigator: Paula Mosińska

Uniwersytet Medyczny w Łodzi, Wydzial Lekarski

Multifunctional inhibitors of beta-secretase with anti-aggregating properties of neurotoxic peptides - beta-amyloid and ...

Call: OPUS 11 , Panel: NZ7

Principal investigator: prof. Barbara Antonina Malawska

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

INNOvative antiSEPTic agents for a therapy with a broad spectrum of action

Call: OPUS 10 , Panel: NZ7

Principal investigator: dr Sebastian Kraszewski

Politechnika Wrocławska

Simultaneous stimulation of muscarinic M4 receptor and selected receptors involved in the regulation of glutamate releas...

Call: OPUS 9 , Panel: NZ7

Principal investigator: dr hab. Joanna Monika Wierońska

Instytut Farmakologii PAN

Identification and structural characterization of the primordial cytotoxic conformers of the amyloidogenic cascade: Idea...

Call: UNISONO , Panel: NZ1

Principal investigator: prof. Marek Cieplak

Instytut Fizyki PAN

Functional Characterization of Non-Collagenous Extracellular Matrix Proteins as a Potential Molecular Target and Novel B...

Call: SONATA 8 , Panel: NZ5

Principal investigator: dr Michał Andrzej Pawlak

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Approach to structures of difficult protein targets using new mass spectrometry-based methods

Call: MAESTRO 6 , Panel: NZ1

Principal investigator: prof. Michał Lech Dadlez

Instytut Biochemii i Biofizyki PAN