Projects funded by the NCN

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57 projects found matching your search criteria :

  1. Dual-Target Compounds Modulating EAAT2 and Kv7.2/3 Channels: A Rational Strategy Toward Novel Antiseizure and Antinocice...

    Call: OPUS 29 , Panel: NZ7

    Principal investigator: dr Michał Andrzej Abram

    Uniwersytet Jagielloński

  2. Positioning the aryl hydrocarbon receptor (AhR) as a new target for pharmacotherapy of sporadic Alzheimer disease: verif...

    Call: OPUS 28 , Panel: NZ7

    Principal investigator: prof. Małgorzata Kajta

    Instytut Farmakologii PAN

  3. Investigation of the mechanism of enhanced liposome delivery to tumors and its application for dual target immunotherapy

    Call: OPUS 28 , Panel: NZ7

    Principal investigator: dr hab. Tomasz Piotr Rygiel

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  4. Disruption of the posttranslational activation of the translation factor EF-P as a new target for antimicrobial agents.

    Call: OPUS 27 , Panel: NZ7

    Principal investigator: dr Piotr Wilk

    Uniwersytet Jagielloński

  5. Two-body currents in the electron and neutrino scattering off few-nucleon targets

    Call: IMPRESS-U , Panel: ST2

    Principal investigator: prof. Jacek Golak

    Uniwersytet Jagielloński

  6. The inhibition of NMDAR and TRPM4 coupling - a hope for novel therapeutic target for the treatment of the ischemic brain...

    Call: SONATA BIS 13 , Panel: NZ7

    Principal investigator: dr Bartosz Sebastian Pomierny

    Uniwersytet Jagielloński, Collegium Medicum

  7. Directed screening and evaluation of novel bactericidal compounds active againsttubercle bacilli and Mycobacterium absce...

    Call: OPUS 25 , Panel: NZ7

    Principal investigator: prof. Jarosław Dziadek

    Instytut Biologii Medycznej PAN

  8. The Role of the Mitochondrial Unfolded Protein Response (UPRmt) in Endothelial Function: a Possible Novel Target for the...

    Call: PRELUDIUM 22 , Panel: NZ7

    Principal investigator: Sylwester Tycjan Mosiołek

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  9. Gaining control on XBP1s signaling as a starting point for novel cancer therapies

    Call: OPUS 24 , Panel: NZ7

    Principal investigator: prof. Rafał Artur Bartoszewski

    Uniwersytet Wrocławski, Wydział Biotechnologii

  10. Studies on the post-receptor mechanisms of TSPO in search of a novel therapeutic target of metabolic syndrome

    Call: PRELUDIUM 21 , Panel: NZ7

    Principal investigator: dr Łukasz Kurach

    Uniwersytet Medyczny w Lublinie

  11. Brain cytochrome P450 as a new target for the treatment of neurological and psychiatric diseases. Studies with human neu...

    Call: OPUS 23 , Panel: NZ7

    Principal investigator: prof. Władysława Anna Daniel

    Instytut Farmakologii PAN

  12. The role of simultaneous and individual modulation of μ-opioid, sigma-1 and histamine H3 receptors as a new therapeutic ...

    Call: OPUS 23 , Panel: NZ7

    Principal investigator: dr Katarzyna Anna Szczepańska

    Instytut Farmakologii PAN

  13. Omics-guided engineering of a secretory pathway for enhanced synthesis of secretory proteins in Yarrowia lipolytica - fu...

    Call: PRELUDIUM 21 , Panel: NZ9

    Principal investigator: dr Paulina Anna Korpys-Woźniak

    Uniwersytet Przyrodniczy w Poznaniu, Wydział Nauk o Żywności i Żywieniu

  14. Novel broad-spectrum central nervous system active substances: optimization of their multi-target profile

    Call: OPUS 22 , Panel: NZ7

    Principal investigator: dr hab. Agnieszka Anna Kaczor

    Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

  15. Studies on anti-inflammatory properties of GPR18 ligands and their involvement in modulation of microglia phenotypes – a...

    Call: OPUS 22 , Panel: NZ7

    Principal investigator: prof. Katarzyna Justyna Kieć-Kononowicz

    Uniwersytet Jagielloński, Collegium Medicum

  16. Research of multifunctional compounds targeting neuroinflammation and cholinergic deficit in Alzheimer's disease

    Call: OPUS 22 (LAP) , Panel: NZ7

    Principal investigator: prof. Kinga Aleksandra Sałat

    Uniwersytet Jagielloński, Collegium Medicum

  17. In search for molecular targets to overcome doxorubicin resistance in triple-negative breast cancer with the use of inno...

    Call: PRELUDIUM 20 , Panel: NZ7

    Principal investigator: Anna Karolina Pogorzelska

    Narodowy Instytut Leków

  18. Aging-associated, specific pathomechanisms of endothelial dysfunction in sepsis: pathway analysis and experimental thera...

    Call: WEAVE-UNISONO , Panel: NZ7

    Principal investigator: prof. Stefan Karol Chłopicki

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  19. Enzymes of the L-methionine biosynthetic pathway as novel moleculartargets for antifungal chemotherapy

    Call: OPUS 20 , Panel: NZ7

    Principal investigator: dr hab. Iwona Aniela Gabriel

    Politechnika Gdańska, Wydział Chemiczny

  20. The study on the molecular mechanisms of cytotoxic activity of new compounds ZOT5-1-Me and ZOT5-1-Et in an experimental ...

    Call: SONATA 16 , Panel: NZ7

    Principal investigator: dr Paulina Anna Tokarz

    Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

  21. Identification of surface proteins as alternate targets for CAR-T therapy against CD19-negative tumors.

    Call: PRELUDIUM BIS 2 , Panel: NZ6

    Principal investigator: dr hab. Magdalena Hanna Winiarska

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  22. Drug repurposing to target p53 protein family for improved therapy in the relapsed TP53 and EGFR mutated lung cancer

    Call: OPUS 20 , Panel: NZ7

    Principal investigator: dr Joanna Elżbieta Zawacka-Pankau

    Warszawski Uniwersytet Medyczny

  23. DNA polymerase θ as a novel therapeutic target in personalized anticancer therapy

    Call: OPUS 19 , Panel: NZ7

    Principal investigator: prof. Tomasz Adam Śliwiński

    Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

  24. New multifunctional drug-like ligands focusing on molecular targets associated with the symptoms and causes of Alzheimer...

    Call: PRELUDIUM 19 , Panel: NZ7

    Principal investigator: Anna Marta Pasieka

    Uniwersytet Jagielloński, Collegium Medicum

  25. Novel approach in the search for asthma and COPD therapies - computer aided design of multi-target-directed ligands bloc...

    Call: PRELUDIUM 19 , Panel: NZ7

    Principal investigator: Alicja Aleksandra Gawalska

    Uniwersytet Jagielloński, Collegium Medicum

  26. Physical exercise as a natural mechanism inducing neuroregeneration. Search for the new protein markers and therapeutic ...

    Call: OPUS 18 , Panel: NZ7

    Principal investigator: dr hab. Katarzyna Zofia Kuter-Nowak

    Instytut Farmakologii PAN

  27. Gankyrin protein as a new potential therapeutic target in multiple myeloma

    Call: OPUS 18 , Panel: NZ5

    Principal investigator: dr hab. Irena Misiewicz-Krzemińska

    Instytut Hematologii i Transfuzjologii

  28. Biased multi-target ligands as tools for activity pattern analysis of G protein-coupled receptors in cancer cells

    Call: SONATA 14 , Panel: NZ7

    Principal investigator: dr Artur Wnorowski

    Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej

  29. The effect of thiol redox regulators on seed quality and the aging process

    Call: OPUS 16 , Panel: NZ9

    Principal investigator: dr hab. Ewelina Antonina Ratajczak

    Instytut Dendrologii PAN

  30. Determination of targets for peptidylarginine deiminase type 4 (PAD4) among complement system proteins and assessment of...

    Call: HARMONIA 10 , Panel: NZ1

    Principal investigator: dr Ewa Izabela Bielecka

    Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

  31. Opioid-induced analgesia and hyperalgesia in neuropathic pain - mechanisms and druggable targets

    Call: OPUS 15 , Panel: NZ7

    Principal investigator: prof. Barbara Elżbieta Przewłocka

    Instytut Farmakologii PAN

  32. Novel multi-target ligands of aminergic GPCRs as pharmacological tools to study the pathomechanism of schzophrenia

    Call: OPUS 14 , Panel: NZ7

    Principal investigator: dr hab. Agnieszka Anna Kaczor

    Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

  33. The enzymes of RNA metabolism, PAP I and PNPase, as targets for new antimycobacterial drugs and their functional charact...

    Call: OPUS 13 , Panel: NZ7

    Principal investigator: prof. Jarosław Dziadek

    Instytut Biologii Medycznej PAN

  34. Peroxiredoxins as potential therapeutic targets in glioblastoma.

    Call: OPUS 13 , Panel: NZ7

    Principal investigator: dr hab. Monika Paulina Szeliga

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  35. Novel 2,4-disubstituted pyridine derivatives - synthesis, antimycobacterial activity in vitro, pharmacophore model, mole...

    Call: OPUS 13 , Panel: NZ7

    Principal investigator: dr hab. Katarzyna Małgorzata Gobis

    Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

  36. New mulitple target-directed ligands - A1/A2A adenosine receptors antagonists and monoamine oxidase B inhibitors - searc...

    Call: PRELUDIUM 12 , Panel: NZ7

    Principal investigator: Michał Karol Załuski

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

  37. Identification of Mycobacterium tuberculosis ligands binding human serum amyloid A (SAA) and biological function of tube...

    Call: OPUS 12 , Panel: NZ7

    Principal investigator: dr hab. Bożena Renata Dziadek

    Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

  38. Determination of the mechanisms and potential targets for neuropathic pain therapy by investigating pharmacological inte...

    Call: PRELUDIUM 12 , Panel: NZ7

    Principal investigator: Anna Piotrowska-Murzyn

    Instytut Farmakologii PAN

  39. Novel multi-target directed ligands combining cholinesterase inhibition and 5-HT6 antagonism - design, synthesis and pha...

    Call: SONATA 12 , Panel: NZ7

    Principal investigator: dr hab. Anna Karolina Więckowska

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

  40. Modeling of structure of gamma-aminobutyric acid transporters as an essential biological and therapeutic target

    Call: SONATA 12 , Panel: NZ7

    Principal investigator: dr hab. Marek Wojciech Bajda

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

  41. New 2(5H)-furanone derivatives with tailored hydrophobicity of substitutents - synthesis, molecular targets, mechanism o...

    Call: OPUS 11 , Panel: NZ7

    Principal investigator: prof. Krzysztof Zdzisław Walczak

    Politechnika Śląska, Wydział Chemiczny

  42. Modulation of fatty acid binding protein 4 and dietary fatty acid intake as a potential therapeutic target in the manage...

    Call: PRELUDIUM 11 , Panel: NZ5

    Principal investigator: Paula Mosińska

    Uniwersytet Medyczny w Łodzi, Wydzial Lekarski

  43. Multifunctional inhibitors of beta-secretase with anti-aggregating properties of neurotoxic peptides - beta-amyloid and ...

    Call: OPUS 11 , Panel: NZ7

    Principal investigator: prof. Barbara Antonina Malawska

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

  44. INNOvative antiSEPTic agents for a therapy with a broad spectrum of action

    Call: OPUS 10 , Panel: NZ7

    Principal investigator: dr Sebastian Kraszewski

    Politechnika Wrocławska

  45. Simultaneous stimulation of muscarinic M4 receptor and selected receptors involved in the regulation of glutamate releas...

    Call: OPUS 9 , Panel: NZ7

    Principal investigator: dr hab. Joanna Monika Wierońska

    Instytut Farmakologii PAN

  46. Identification and structural characterization of the primordial cytotoxic conformers of the amyloidogenic cascade: Idea...

    Call: UNISONO , Panel: NZ1

    Principal investigator: prof. Marek Cieplak

    Instytut Fizyki PAN

  47. Functional Characterization of Non-Collagenous Extracellular Matrix Proteins as a Potential Molecular Target and Novel B...

    Call: SONATA 8 , Panel: NZ5

    Principal investigator: dr Michał Andrzej Pawlak

    Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

  48. Approach to structures of difficult protein targets using new mass spectrometry-based methods

    Call: MAESTRO 6 , Panel: NZ1

    Principal investigator: prof. Michał Lech Dadlez

    Instytut Biochemii i Biofizyki PAN

  49. Identification of proline metabolic pathway as a molecular target for experimental regulation of apoptosis/autophagy in ...

    Call: OPUS 7 , Panel: NZ7

    Principal investigator: prof. Jerzy Aleksander Pałka

    Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

  50. Research on human eosinophils as a potential therapeutic target.

    Call: PRELUDIUM 7 , Panel: NZ7

    Principal investigator: Marek Rafał Grosicki

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

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