Targeted degradation of Rab geranylgeranyl transferase as a new approach to investigate prenylation of Rab GTPases
2020/39/O/NZ1/02418
Keywords
Descriptors
- NZ1_001: Biologia molekularna
- NZ5_007: Leczenie chorób człowieka
- NZ5_001: Etiologia chorób człowieka
Panel
NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution
Politechnika Łódzka, Wydział Biotechnologii i Nauk o Żywności
Voivodeship: łódzkie
Principal investigator (from the host institution)
dr hab. Edyta Violetta Gendaszewska-Darmach
Number of co-investigators in the project: 2
Call
PRELUDIUM BIS 2 – announced on 2020-09-15
- Amount awarded
- 541 600 PLN
- Project start date
- 2021-10-01
- Project end date
- 2026-09-30
- Project duration
- 60 months (the same as in the proposal)
- Project status
- Pending project
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (3)
-
Protein Prenyltransferases and Their Inhibitors: Structural and Functional Characterization
- Authors:
- Aleksandra Marchwicka, Daria Kamińska, Mohsen Monirialamdari, Katarzyna M Błażewska, Edyta Gendaszewska-Darmach
- Academic press:
- International Journal of Molecular Sciences (year: 2022, volume: 23, pages: 5424), Publisher: MDPI, Basel, Switzerland
- Status:
- Published
- DOI:
- 10.3390/ijms23105424 – link to the publication
-
Targeting reversible post-translational modifications with PROTACs: a focus on enzymes modifying protein lysine and arginine residues
- Authors:
- Marta Pichlak, Tomasz Sobierajski, Katarzyna Błażewska, Edyta Gendaszewska-Darmach
- Academic press:
- Journal of Enzyme Inhibition and Medicinal Chemistry (year: 2023, volume: 38, pages: 2254012), Publisher: Taylor & Francis
- Status:
- Published
- DOI:
- 10.1080/14756366.2023.2254012 – link to the publication
-
The impact of E3 ligase choice on PROTAC effectiveness in protein kinase degradation
- Authors:
- Tomasz Sobierajski, Joanna Małolepsza, Marta Pichlak, Edyta Gendaszewska-Darmach, Katarzyna M Błazewska
- Academic press:
- Drug Discovery Today (year: 2024, volume: 29, pages: 104032), Publisher: Elsevier Ltd.
- Status:
- Published
- DOI:
- 10.1016/j.drudis.2024.104032 – link to the publication