Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Coupling of synthesis and transport for proteins targeted to the mitochondria

2013/11/B/NZ3/00974

Keywords:

mitochondria quality control protein transport protein synthesis ribosome translation

Descriptors:

  • NZ3_1: Cell biology
  • NZ1_2: Biochemistry
  • NZ1_1: Molecular biology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Agnieszka Chacińska 

Number of co-investigators in the project: 4

Call: OPUS 6 - announced on 2013-09-16

Amount awarded: 1 165 520 PLN

Project start date (Y-m-d): 2014-07-24

Project end date (Y-m-d): 2018-04-23

Project duration:: 45 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Ekran do odczytu radiaktywności (11 000 PLN)
  2. Aparat do transferu białek (3 690 PLN)
  3. Nablatowa komora laminarna (7 461 PLN)
  4. Wirówka z chłodzeniem (25 000 PLN)
  5. Zestaw do elektroforezy białek (2 937 PLN)
  6. Laptop (8 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Cytosolic ribosomes on the surface of mitochondria
    Authors:
    Gold V.A.M., Chroscicki P., Bragoszewski P., Chacinska A.
    Academic press:
    bioRxiv (rok: 2017, tom: nie dotyczy, strony: nie dotyczy), Wydawca: Cold Spring Harbor Laboratory
    Status:
    Published
    DOI:
    10.1101/119339 - link to the publication
  2. Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol
    Authors:
    Wrobel L., Topf U., Bragoszewski P., Wiese S., Sztolsztener M.E., Oeljeklaus S., Varabyova A., Lirski M., Chroscicki P., Mroczek S., Januszewicz E., Dziembowski A., Koblowska M., Warscheid B., Chacinska A.
    Academic press:
    Nature (rok: 2015, tom: vol. 524 (7566), strony: 485-488), Wydawca: Macmillan Publishers Ltd.
    Status:
    Published
    DOI:
    10.1038/nature14951 - link to the publication
  3. Mitochondrial protein import stress and signaling. Curr. Opin. Physiol. 03, 41–48.
    Authors:
    Samluk Ł., Chroscicki P., Chacinska A.
    Academic press:
    Curr. Opin. Physiol (rok: 2018, tom: 3, strony: 41-48), Wydawca: Elsevier
    Status:
    Published
    DOI:
    https://linkinghub.elsevier.com/retrieve/pii/S2468867318300324 - link to the publication
  4. The Oxidation Status of Mic19 Regulates MICOS Assembly
    Authors:
    Sakowska P., Jans D.C., Mohanraj K., Riedel D., Jakobs S., Chacinska A.
    Academic press:
    Molecular and Cellular Biology (rok: 2015, tom: vol. 35 no. 24, strony: 4222-4237), Wydawca: American Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/MCB.00578-15 - link to the publication
  5. Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species.
    Authors:
    Topf U., Suppanz I., Samluk Ł., Wrobel L., Böser A., Sakowska P., Knapp B., Pietrzyk M.K., Chacinska A., Warscheid B
    Academic press:
    Nat. Commun. (rok: 2018, tom: 9, strony: 324), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41467-017-02694-8 - link to the publication

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