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Targeting deregulated expression of anti-apoptotic proteins belonging to the Bcl-2 family in macrophages as a potential therapy against periodontal disease.

2020/39/D/NZ5/02075

Keywords:

periodontitis Porphyromonas gingivalis apoptosis macrophages inflammation

Descriptors:

  • NZ5_003:
  • NZ5_007:
  • NZ3_003:

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Maja Anna Sochalska 

Number of co-investigators in the project: 4

Call: SONATA 16 - announced on 2020-09-15

Amount awarded: 1 599 000 PLN

Project start date (Y-m-d): 2021-07-20

Project end date (Y-m-d): 2026-07-19

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. Porphyromonas gingivalis affects neutrophil pro-inflammatory activities
    Authors:
    Zimny Agnieszka, Płonczyńska Alicja, Jakubowski Wiktor, Zubrzycka Natalia, Potempa Jan, Sochalska Maja
    Academic press:
    Frontiers in Cell and Developmental Biology (rok: 2025, tom: 13, strony: 46035), Wydawca: Frontiers.org
    Status:
    Published
    DOI:
    10.3389/fcell.2025.1419651 - link to the publication
  2. Inhibition of BTK and SYK attenuates Porphyromonas gingivalis -induced activation of the pyroptosis pathway and inflammation in host cells
    Authors:
    Płonczyńska Alicja, Szuster Auteliusz, Drapała M Dominika, Kaczmarzyk Tomasz, Nowak Magdalena, Potempa Jan, Grabiec M Aleksander, Sochalska Maja
    Academic press:
    Journal of Oral Microbiology (rok: 2025, tom: 17, strony: 46035), Wydawca: Taylor & Francis group
    Status:
    Published
    DOI:
    10.1080/20002297.2025.2577219 - link to the publication
  3. Polyethylene Glycols Stimulate Ca2+ Signaling, Cytokine Production, and the Formation of Neutrophil Extracellular Traps
    Authors:
    Hinz A, Stankiewicz S, Litewka JJ, Ferdek PE, Sochalska M, Bzowska M.
    Academic press:
    International Journal of Nanomedicine (rok: 2024, tom: 19, strony: 3165–13181), Wydawca: Dovepress
    Status:
    Published
    DOI:
    10.2147/IJN.S479710 - link to the publication

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