Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

DNA double-stranded break repair proteins as a target for personalized cancer therapy based on synthetic lethality

2012/07/B/NZ7/04245

Keywords:

DNA double-stranded breaks DNA repair inhibitors of DNA double-stranded break repair proteins synthetic lethality personalized cancer therapy

Descriptors:

  • NZ7_12: Prevention of human diseases

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Tomasz Śliwiński 

Number of co-investigators in the project: 7

Call: OPUS 4 - announced on 2012-09-15

Amount awarded: 509 995 PLN

Project start date (Y-m-d): 2013-07-02

Project end date (Y-m-d): 2017-01-01

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Inkubator do hodowli komórkowych z atmosferą CO2 (40 000 PLN)
  2. Dewar do przechowywania materiału biologicznego w ciekłym azocie. (6 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (1)
  1. DNA double strand break repair - related synthetic lethality.
    Authors:
    Toma M, Skorski T, Sliwinski T.
    Academic press:
    Curr Med Chem. (rok: 2018, tom: 25, strony: 13516), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/0929867325666180201114306 - link to the publication
  2. Syntetyczna letalność jako funkcjonalne narzędzie w badaniach podstawowych oraz w terapii przeciwnowotworowej.
    Authors:
    Toma M, Skorski T, Sliwinski T
    Academic press:
    Postepy Hig Med Dosw (Online). (rok: 2014, tom: 68, strony: 1091-1103), Wydawca: Index Copernicus International
    Status:
    Published
    DOI:
    10.5604/17322693.1119792 - link to the publication
  3. PARP1 inhibitor olaparib (Lynparza) exerts synthetic lethal effect against ligase 4-deficient melanomas
    Authors:
    Czyż M, Toma M, Gajos-Michniewicz A, Majchrzak K, Hoser G, Szemraj J, Nieborowska-Skorska M, Cheng P, Gritsyuk D, Levesque M, Dummer R, Sliwinski T, Skorski T.
    Academic press:
    Oncotarget (rok: 2016, tom: 7(46), strony: 75551-75560), Wydawca: Impact journals
    Status:
    Published
    DOI:
    10.18632/oncotarget.12270 - link to the publication
  1. PERSONALIZED SYNTHETIC LETHALITY INDUCED BY TARGETING RAD52 AND PARP1 IN MELANOMAS
    Authors:
    Monika Toma, Anna Gajos-Michniewicz, Kinga Majchrzak, Łukasz Wieteska, Janusz Szemraj, Małgorzata Czyż, Tomasz Skorski and Tomasz Śliwiński
    Conference:
    9th International Conference of Anticancer Research (rok: 2014, ), Wydawca: ANTICANCER RESEARCH - The International Institute of Anticancer Research
    Data:
    konferencja 6-10 października 2014
    Status:
    Published