DNA double-stranded break repair proteins as a target for personalized cancer therapy based on synthetic lethality
2012/07/B/NZ7/04245
Keywords
Descriptors
- NZ7_12: Prewencja chorób człowieka
Panel
NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution
Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska
Voivodeship: łódzkie
Principal investigator (from the host institution)
Number of co-investigators in the project: 7
Call
OPUS 4 – announced on 2012-09-15
- Amount awarded
- 509 995 PLN
- Project start date
- 2013-07-02
- Project end date
- 2017-01-01
- Project duration
- 42 months (the same as in the proposal)
- Project status
- Project settled
Equipment purchased [PL]
- Dewar do przechowywania materiału biologicznego w ciekłym azocie.. Cost: 6 000 PLN
- Inkubator do hodowli komórkowych z atmosferą CO2. Cost: 40 000 PLN
Information in the final report
Publication in academic press/journals (3)
-
PARP1 inhibitor olaparib (Lynparza) exerts synthetic lethal effect against ligase 4-deficient melanomas
- Authors:
- Czyż M, Toma M, Gajos-Michniewicz A, Majchrzak K, Hoser G, Szemraj J, Nieborowska-Skorska M, Cheng P, Gritsyuk D, Levesque M, Dummer R, Sliwinski T, Skorski T.
- Academic press:
- Oncotarget (year: 2016, volume: 7(46), pages: 75551-75560), Publisher: Impact journals
- Status:
- Published
- DOI:
- 10.18632/oncotarget.12270 – link to the publication
-
Syntetyczna letalność jako funkcjonalne narzędzie w badaniach podstawowych oraz w terapii przeciwnowotworowej.
- Authors:
- Toma M, Skorski T, Sliwinski T
- Academic press:
- Postepy Hig Med Dosw (Online). (year: 2014, volume: 68, pages: 1091-1103), Publisher: Index Copernicus International
- Status:
- Published
- DOI:
- 10.5604/17322693.1119792 – link to the publication
-
DNA double strand break repair - related synthetic lethality.
- Authors:
- Toma M, Skorski T, Sliwinski T.
- Academic press:
- Curr Med Chem. (year: 2018, volume: 25, pages: 13516), Publisher: Bentham Science
- Status:
- Published
- DOI:
- 10.2174/0929867325666180201114306 – link to the publication
Articles in post-conference publications (1)
-
PERSONALIZED SYNTHETIC LETHALITY INDUCED BY TARGETING RAD52 AND PARP1 IN MELANOMAS
- Authors:
- Monika Toma, Anna Gajos-Michniewicz, Kinga Majchrzak, Łukasz Wieteska, Janusz Szemraj, Małgorzata Czyż, Tomasz Skorski and Tomasz Śliwiński
- Conference:
- 9th International Conference of Anticancer Research (year: 2014, pages: 6173), Publisher: ANTICANCER RESEARCH - The International Institute of Anticancer Research
- Date:
- conference 6-10 października 2014
- Status:
- Published