Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Targeting cell surface proteoglycans with high affinity multimeric ligands and their cytotoxic conjugates – towards precision medicine for pancreatic cancer

2021/43/B/NZ1/00245

Keywords:

Pancreatic cancer HSPGs proteoglycans cancer marker FGF FGFR signaling endocytosis cytotoxic conjugates protein oligomerization protein engineering

Descriptors:

  • NZ1_009:
  • NZ1_002:
  • NZ3_007:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Wrocławski, Wydział Biotechnologii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Łukasz Opaliński 

Number of co-investigators in the project: 6

Call: OPUS 22 - announced on 2021-09-15

Amount awarded: 1 964 000 PLN

Project start date (Y-m-d): 2022-10-03

Project end date (Y-m-d): 2026-10-02

Project duration:: 48 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. Multivalent protein-drug conjugates - An emerging strategy for the upgraded precision and efficiency of drug delivery to cancer cells
    Authors:
    Porebska N, Ciura K, Chorazewska A, Zakrzewska M, Otlewski J, Opalinski Ł
    Academic press:
    Biotechnology Advances (rok: 2023, tom: 67, strony: 108213), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biotechadv.2023.108213 - link to the publication
  2. Targeting HER2 and FGFR-positive cancer cells with a bispecific cytotoxic conjugate combining anti-HER2 Affibody and FGF2
    Authors:
    Krzyscik M, Porebska N, Opalinski Ł, Otlewski J
    Academic press:
    International Journal of Biological Macromolecules (rok: 2023, tom: 254, strony: 127657), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2023.127657 - link to the publication
  3. Glycosylation of FGF/FGFR: An underrated sweet code regulating cellular signaling programs
    Authors:
    Gędaj A, Gregorczyk P, Żukowska D, Chorążewska A, Ciura K, Kalka M, Porębska N, Opaliński Ł
    Academic press:
    Cytokines and Growth Factor Reviews (rok: 2024, tom: 77, strony: 39-55), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cytogfr.2024.04.001 - link to the publication
  4. N-glycosylation acts as a switch for FGFR1 trafficking between the plasma membrane and nuclear envelope
    Authors:
    Autor/Autorzy Gregorczyk P, Porebska N, Zukowska D, Chorazewska A, Gedaj A, Malinowska A, Otlewski J, Zakrzewska M, Opalinski Ł
    Academic press:
    Cell Communication and Signaling (rok: 2023, tom: 21 (1), strony: 177), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12964-023-01203-3 - link to the publication

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