Targeting cell surface proteoglycans with high affinity multimeric ligands and their cytotoxic conjugates – towards precision medicine for pancreatic cancer
2021/43/B/NZ1/00245
Keywords
Descriptors
- NZ1_009: Biotechnologia
- NZ1_002: Biochemia
- NZ3_007: Przekaźnictwo sygnału
Panel
NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution
Uniwersytet Wrocławski, Wydział Biotechnologii
Voivodeship: dolnośląskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 6
Call
OPUS 22 – announced on 2021-09-15
- Amount awarded
- 1 964 000 PLN
- Project start date
- 2022-10-03
- Project end date
- 2027-10-02
- Project duration
- 60 months (the same as in the proposal)
- Project status
- Pending project
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (7)
-
Glycosylation of FGF/FGFR: An underrated sweet code regulating cellular signaling programs
- Authors:
- Gędaj A, Gregorczyk P, Żukowska D, Chorążewska A, Ciura K, Kalka M, Porębska N, Opaliński Ł
- Academic press:
- Cytokines and Growth Factor Reviews (year: 2024, volume: 77, pages: 39-55), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.cytogfr.2024.04.001 – link to the publication
-
Dissecting the specificity of sugar code recognition - Unleashing the biomedical potential of galectins by protein engineering
- Authors:
- Marta Kalka , Julia Ptak , Paulina Gregorczyk , Krzysztof Ciura , Aleksandra Chorążewska , Subhradeep Haldar , Natalia Porębska , Ewa Marcinkowska, Łukasz Opaliński
- Academic press:
- Biotechnology Advances (year: 2025, volume: 84, pages: 108681), Publisher: ELSEVIER
- Status:
- Published
- DOI:
- 10.1016/j.biotechadv.2025.108681 – link to the publication
-
Reprogramming FGF1 from the natural growth factor to the engineered heparan sulphate biosensor
- Authors:
- Krzysztof Ciura, Olimpia Sobota, Aleksandra Chorążewska, Daniel Krowarsch, Natalia Porębska, Łukasz Opaliński
- Academic press:
- Cell Communication and Signaling (year: 2025, volume: 23, pages: 248), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1186/s12964-025-02269-x – link to the publication
-
Multivalent protein-drug conjugates - An emerging strategy for the upgraded precision and efficiency of drug delivery to cancer cells
- Authors:
- Porebska N, Ciura K, Chorazewska A, Zakrzewska M, Otlewski J, Opalinski Ł
- Academic press:
- Biotechnology Advances (year: 2023, volume: 67, pages: 108213), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.biotechadv.2023.108213 – link to the publication
-
Targeting HER2 and FGFR-positive cancer cells with a bispecific cytotoxic conjugate combining anti-HER2 Affibody and FGF2
- Authors:
- Krzyscik M, Porebska N, Opalinski Ł, Otlewski J
- Academic press:
- International Journal of Biological Macromolecules (year: 2023, volume: 254, pages: 127657), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.ijbiomac.2023.127657 – link to the publication
-
Innately Fluorescent Tetravalent Cytotoxic Conjugate TetraFHER2-vcMMAE Engages Aggregation-Dependent Endocytosis of HER2 for Enhanced Intracellular Drug Delivery
- Authors:
- Natalia Porębska, Aleksandra Chorążewska, Krzysztof Ciura, Adam Pomorski, Artur Krężel, Łukasz Opaliński
- Academic press:
- Journal of Medicinal Chemistry (year: 2025, volume: 68, pages: 13872-13886), Publisher: ACS
- Status:
- Published
- DOI:
- 10.1021/acs.jmedchem.5c00782 – link to the publication
-
N-glycosylation acts as a switch for FGFR1 trafficking between the plasma membrane and nuclear envelope
- Authors:
- Autor/Autorzy Gregorczyk P, Porebska N, Zukowska D, Chorazewska A, Gedaj A, Malinowska A, Otlewski J, Zakrzewska M, Opalinski Ł
- Academic press:
- Cell Communication and Signaling (year: 2023, volume: 21 (1), pages: 177), Publisher: BMC
- Status:
- Published
- DOI:
- 10.1186/s12964-023-01203-3 – link to the publication