Projects funded by the NCN

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Determination of targets for peptidylarginine deiminase type 4 (PAD4) among complement system proteins and assessment of citrullination influence on their biological activity.

2018/30/M/NZ1/00367

Keywords:

peptidylarginine deiminase type 4 PAD4 citrullination complement system posttranslational modifications

Descriptors:

  • NZ1_2: Biochemistry
  • NZ6_1: Adaptive and innate immunity

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Ewa Bielecka 

Number of co-investigators in the project: 3

Call: HARMONIA 10 - announced on 2018-06-15

Amount awarded: 825 458 PLN

Project start date (Y-m-d): 2019-05-13

Project end date (Y-m-d): 2024-05-12

Project duration:: 24 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. Citrullination of C1-inhibitor as a mechanism of impaired complement regulation in rheumatoid arthritis
    Authors:
    Myriam Martin, Sara C Nilsson, David Eikrem, Karin Fromell, Carsten Scavenius, Leonie M Vogt, Ewa Bielecka, Jan Potempa, Jan J Enghild, Bo Nilsson, Kristina N Ekdahl , Meliha C Kapetanovic , Anna M Blom
    Academic press:
    Frontiers in Immunology (rok: 2023, tom: 14:1203506, strony: 1203506), Wydawca: Frontiers Media S.A
    Status:
    Published
    DOI:
    10.3389/fimmu.2023.1203506 - link to the publication
  2. Apolipoprotein E Triggers Complement Activation in Joint Synovial Fluid of Rheumatoid Arthritis Patients by Binding C1q
    Authors:
    Leonie M Vogt, Ewa Kwasniewicz, Simone Talens, Carsten Scavenius , Ewa Bielecka, Kristina N Ekdahl, Jan J Enghild, Matthias Mörgelin, Tore Saxne, Jan Potempa, Anna M Blom
    Academic press:
    Journal of Immunology (rok: 2020, tom: 204(10), strony: 2779-2790), Wydawca: The American Association of Immunologists, Inc
    Status:
    Published
    DOI:
    10.4049/jimmunol.1900372 - link to the publication
  3. Citrullination-Resistant LL-37 Is a Potent Antimicrobial Agent in the Inflammatory Environment High in Arginine Deiminase Activity
    Authors:
    Bryzek D, Golda A, Budziaszek J, Kowalczyk D, Wong A, Bielecka E, Shakamuri P, Svoboda P, Pohl J, Potempa J, Koziel J
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21(23), strony: 9126), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21239126 - link to the publication

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