Projects funded by the NCN

Disrupting the Toxic NMDAR/TRPM4 Protein Dialogue as a Novel Neuroprotective Strategy: Development of Small-Molecule Inh...

Call: PRELUDIUM 24 , Panel: NZ7

Principal investigator: Katarzyna Aleksandra Szafrańska

Uniwersytet Jagielloński

Two Faces of Boron Cations: Merging Lewis Acid and Base Properties for Synthetic and Catalytic Applications

Call: PRELUDIUM 24 , Panel: ST4

Principal investigator: Tomasz Wojnowski

Politechnika Gdańska

Small molecule modulators of the tumor necrosis factor alpha signaling pathway for the inhibition of inflammatory proces...

Call: OPUS 27 , Panel: NZ7

Principal investigator: prof. Tadeusz Holak

Uniwersytet Gdański

Innovative Small Molecule Inhibitors Targeting LAG-3 and MHCII Complex for Tumour Immunotherapy

Call: OPUS 27 , Panel: NZ7

Principal investigator: dr Jacek Plewka

Uniwersytet Jagielloński

A Compound Screening Platform for the Discovery of Histone- and Nucleosome-Targeting Agents

Call: OPUS 27 , Panel: NZ7

Principal investigator: prof. Curtis Davey

Uniwersytet Jagielloński

Targeting adenylate kinase 4 (AK4) as a new paradigm in the treatment of non-small cell lung cancer: discovery and evalu...

Call: OPUS 26 , Panel: NZ7

Principal investigator: dr Magdalena Wujak

Uniwersytet Mikołaja Kopernika, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy

Targeting IGH enhancer RNAs as a therapeutic approach in B-cell lymphoma

Call: SONATA BIS 13 , Panel: NZ1

Principal investigator: dr hab. Agnieszka Dzikiewicz-Krawczyk

Instytut Genetyki Człowieka PAN

Compounds modulating function of telomeric proteins TRF1 and TRF2

Call: OPUS 25 , Panel: NZ7

Principal investigator: prof. Maciej Wojciech Bagiński

Politechnika Gdańska, Wydział Chemiczny

Development of dual immuno-oligo- biosensors for monitoring and controlling of the metastatic colorectal cancer and inve...

Call: OPUS 25 , Panel: ST4

Principal investigator: dr hab. Magdalena Stobiecka

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Instytut Biologii

Investigating mechanisms regulating ALCAM alternative splicing and susceptibility of this molecule to cleavage by shedda...

Call: OPUS 25 , Panel: NZ2

Principal investigator: dr Marta Karolina Wagner

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Dynamics of RNA degrading complexes in bacteria

Call: SONATA BIS 12 , Panel: NZ1

Principal investigator: dr Ewelina Magdalena Małecka-Grajek

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Modulation of HIV-1 epitranscriptome: A novel approach to improve "shock & kill" therapy.

Call: PRELUDIUM 21 , Panel: NZ6

Principal investigator: Haider Ali brak danych

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Small-molecule inhibitors of protein aggregation and ER stress as a novel strategy against neurodegeneration in the cour...

Call: PRELUDIUM BIS 3 , Panel: NZ5

Principal investigator: prof. Ireneusz Jacek Majsterek

Uniwersytet Medyczny w Łodzi

Antiviral strategies targeting RNA: Triplex forming peptide nucleic acids (PNA) and their small molecule conjugates spec...

Call: OPUS 21 , Panel: NZ1

Principal investigator: prof. Elżbieta Beata Kierzek

Instytut Chemii Bioorganicznej PAN

The SAR analysis and synthesis of complex, small molecule PD-1/PD-L1 interaction antagonists

Call: PRELUDIUM 20 , Panel: ST4

Principal investigator: Magdalena Maria Żarnik

Uniwersytet Jagielloński, Wydział Chemii

Cell-based high-throughput screening for small-molecule compounds diminishing molecular markers of pathogenesis in myoto...

Call: OPUS 20 , Panel: NZ3

Principal investigator: dr hab. Marzena Wojciechowska

Instytut Chemii Bioorganicznej PAN

Research of a new small-molecule 1,2,4-triazine derivative (MM-129) - assessment of anti-neoplastic activity and safety ...

Call: OPUS 16 , Panel: NZ7

Principal investigator: prof. Dariusz Alfred Pawlak

Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Small molecule tools to investigate local microenvironment of proteins

Call: OPUS 15 , Panel: ST4

Principal investigator: dr Jacek Kolanowski

Instytut Chemii Bioorganicznej PAN

Small-molecule inhibitors for characterization of the interaction between extracellular domains of Programmed Cell Death...

Call: MAESTRO 9 , Panel: ST5

Principal investigator: prof. Tadeusz Andrzej Holak

Uniwersytet Jagielloński, Wydział Chemii

Exploring Baltic Sea cyanobacteria for small-molecule inhibitors of microRNA function

Call: OPUS 13 , Panel: NZ9

Principal investigator: prof. Paweł Michał Brzuzan

Uniwersytet Warmińsko-Mazurski w Olsztynie, Wydział Geoinżynierii

Use of novel small molecule inhibitors of PERK kinase dependent UPR pathway for the colorectal cancer treatment

Call: OPUS 12 , Panel: NZ5

Principal investigator: prof. Adam Janusz Dziki

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

The Design, Synthesis and the Structural Analysis of Small-Molecule Probes for the Targeting of USP2 Deubiquitinase

Call: PRELUDIUM 12 , Panel: ST5

Principal investigator: dr Marcin Dawid Tomala

Uniwersytet Jagielloński, Wydzial Chemii UJ

Use of novel small molecule inhibitors of PERK kinase dependent UPR pathway for the primary open-angle glaucoma treatmen...

Call: OPUS 11 , Panel: NZ5

Principal investigator: prof. Ireneusz Jacek Majsterek

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

In vivo and in vitro structure of influenza virus RNA. The structural determinants behind the inhibition of influenza vi...

Call: OPUS 10 , Panel: NZ1

Principal investigator: prof. Elżbieta Kierzek

Instytut Chemii Bioorganicznej PAN

Synthesis and Struktural Characterization of Small-Molecule Probes for the Programmed Death 1/ Programmed Death Ligand 1...

Call: PRELUDIUM 10 , Panel: ST5

Principal investigator: Katarzyna Agnieszka Guzik

Uniwersytet Jagielloński, Wydział Chemii

From selective detection of cellular oxidants and small molecule signaling agents towards better understanding of their ...

Call: SONATA BIS 5 , Panel: ST4

Principal investigator: dr Adam Bartłomiej Sikora

Politechnika Łódzka, Wydział Chemiczny

Understanding the mechanism of action for small molecule kinase inhibitors in alleviating myotonic dystrophy type 1 (DM1...

Call: OPUS 7 , Panel: NZ5

Principal investigator: dr hab. Marzena Wojciechowska

Instytut Chemii Bioorganicznej PAN

Transient protein states in designing small-molecule inhibitors of protein-protein interactions

Call: SYMFONIA 2 , Panel: NZ1

Principal investigator: prof. Tadeusz Andrzej Holak

Uniwersytet Jagielloński, Wydział Chemii

Investigation of the molecular mechanisms of anti-leukemic activity of SK053, a small molecule compound targeting enzyme...

Call: SONATA BIS 3 , Panel: NZ5

Principal investigator: prof. Dominika Anna Nowis

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Development of a new scoring function for models of protein-small molecule complexes and its use for studying the mechan...

Call: PRELUDIUM 2 , Panel: NZ2

Principal investigator: dr Irina Tuszyńska

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Discovery and development of small-molecule inhibitors of USP2 for targeted, non-genotoxic therapy of cancer

Call: OPUS 1 , Panel: ST5

Principal investigator: prof. Tadeusz Andrzej Holak

Uniwersytet Jagielloński, Wydział Chemii