Projects funded by the NCN

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Antiviral strategies targeting RNA: Triplex forming peptide nucleic acids (PNA) and their small molecule conjugates specific to conserved RNA motifs in Influenza A and SARS-CoV-2

2021/41/B/NZ1/03819

Keywords:

influenza virus SARS-CoV-2 virus RNA replication inhibition small molecules peptide nucleic acids antisense oligonucleotides high-throughput screening

Descriptors:

  • NZ1_004:
  • NZ1_002:
  • ST4_009:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Chemii Bioorganicznej PAN

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Elżbieta Beata Kierzek 

Number of co-investigators in the project: 7

Call: OPUS 21 - announced on 2021-03-15

Amount awarded: 2 331 650 PLN

Project start date (Y-m-d): 2022-02-01

Project end date (Y-m-d): 2027-01-31

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  1. Experimental and computational investigations of RNA duplexes containing N7-regioisomers of adenosine and LNA-adenosine
    Authors:
    I. Yildirim, W. Andralojc, A. Taghavi, D. Baranowski, Z. Gdaniec, R. Kierzek, E. Kierzek
    Academic press:
    Nucleic Acids Research (rok: 2025, tom: 53, strony: gkae1222), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkae1222 - link to the publication
  2. Delivery strategies for RNA-targeting therapeutic nucleic acids and RNA-based vaccines against respiratory RNA viruses: IAV, SARS-CoV-2, RSV
    Authors:
    K. Maziec, A. Baliga-Gil, E. Kierzek
    Academic press:
    Molecular Therapy Nucleic Acids (rok: 2025, tom: 36, strony: 102572), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.omtn.2025.102572 - link to the publication
  3. The oligonucleotides containing N7-regioisomer of guanosine: influence on thermodynamic properties and structure of RNA duplexes
    Authors:
    A. Jarmolowicz, N. Dutta, W. Andralojc, J. Sarzynska, G. Framski, D. Baranowski, J. Boryski, A. Lahiri, Z. Gdaniec, E. Kierzek, R. Kierzek
    Academic press:
    RNA (rok: 2025, tom: 31, strony: 86-99), Wydawca: Cold Spring Harbor Laboratory Press for the RNA Society
    Status:
    Published
    DOI:
    10.1261/rna.080106.124 - link to the publication
  4. Structural and Functional RNA Motifs of SARS-CoV-2 and Influenza A Virus as a Target of Viral Inhibitors
    Authors:
    Szczesniak, I.; Baliga-Gil, A.; Jarmolowicz, A.; Soszynska-Jozwiak, M.; Kierzek, E.
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24, strony: 1232), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24021232 - link to the publication
  5. In vivo secondary structural analysis of Influenza A virus genomic RNA
    Authors:
    B. Mirska, T. Woźniak, D. Lorent, A. Ruszkowska, J. M. Peterson, W. N. Moss, D. H. Mathews, R. Kierzek, E. Kierzek
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2023, tom: 80, strony: 136), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-023-04764-1 - link to the publication
  6. Targeting sgRNA N secondary structure as a way of inhibiting SARS-CoV-2 replication
    Authors:
    A. Baliga-Gil, M. Soszynska-Jozwiak, A. Ruszkowska, I. Szczesniak, R. Kierzek, M. Ciechanowska, M. Trybus, P. Jackowiak, J.M. Peterson, W.N. Moss, E. Kierzek
    Academic press:
    Antiviral Research (rok: 2024, tom: 228, strony: 105946), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.antiviral.2024.105946 - link to the publication

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