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From selective detection of cellular oxidants and small molecule signaling agents towards better understanding of their biological chemistry

2015/18/E/ST4/00235

Keywords

Descriptors

  • ST4_3: Metody spektroskopowe i spektrometryczne
  • ST4_14: Reakcje chemiczne: mechanizmy, termodynamika, kinetyka i kataliza
  • ST4_16: Chemia jądrowa i radiacyjna

Panel

ST4 – Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution

Politechnika Łódzka, Wydział Chemiczny

Voivodeship: łódzkie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Adam Bartłomiej Sikora

Number of co-investigators in the project: 6

Call

SONATA BIS 5 – announced on 2015-06-15

Amount awarded
1 956 784 PLN
Project start date
2016-04-11
Project end date
2022-04-10
Project duration
72 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Inkubator CO2 (taki jak NU-5810E). Cost: 35 000 PLN
  2. Autoklaw poziomy pojemności ok. 65 litrów (taki jak Tuttnauer 3850 EL - CPVG). Cost: 75 000 PLN
  3. Chłodziarka (taka jak LR 500). Cost: 15 000 PLN
  4. Czytnik mikropłytek (taki jak POLARstar Omega). Cost: 300 000 PLN
  5. Komora laminarna z recyrkulacją (taka jak Biohazard NU-480-400). Cost: 50 000 PLN
  6. Mikroskopu odwrócony do obserwacji w technice jasnego pola (Olympus CKX41). Cost: 40 000 PLN
  7. Pojemnik z ciekłwym azotem do przechowywania linii komórkowych (taki jak LS 3000). Cost: 20 000 PLN
  8. Wirówka wielofunkcyjna z mrożeniem (taka jak Eppendors 5430 R). Cost: 30 000 PLN

Information in the final report

Publication in academic press/journals (14)

  1. Mitochondria-targeted metformins: anti-tumour and redox signalling mechanisms.

    Authors:
    Kalyanaraman B, Cheng G, Hardy M, Ouari O, Sikora A, Zielonka J, Dwinell M.
    Academic press:
    Interface Focus (year: 2017, volume: 7, pages: 20160109), Publisher: The Royal Society
    Status:
    Published
    DOI:
    10.1098/rsfs.2016.0109 – link to the publication

  2. Modified Metformin as a More Potent Anticancer Drug: Mitochondrial Inhibition, Redox Signaling, Antiproliferative Effects and Future EPR Studies.

    Authors:
    Kalyanaraman B, Cheng G, Hardy M, Ouari O, Sikora A, Zielonka J, Dwinell MB.
    Academic press:
    Cell Biochemistry and Biophysics (year: 2017, volume: 75, pages: 311-317), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s12013-017-0796-3 – link to the publication

  3. The Chemistry of HNO: Mechanisms and Reaction Kinetics

    Authors:
    Radosław Michalski, Renata Smulik-Izydorczyk, Jakub Pięta, Monika Rola,Angelika Artelska, Karolina Pierzchała, Jacek Zielonka, Balaraman Kalyanaraman Adam Bartłomiej Sikora
    Academic press:
    Frontiers in Chemistry (year: 2022, volume: 10, pages: 930657), Publisher: Frontiers
    Status:
    Published
    DOI:
    10.3389/fchem.2022.930657 – link to the publication

  4. Recent Developments in the Probes and Assays for Measurement of the Activity of NADPH Oxidases.

    Authors:
    Zielonka J, Hardy M, Michalski R, Sikora A, Zielonka M, Cheng G, Ouari O, Podsiadły R, Kalyanaraman B.
    Academic press:
    Cell Biochemistry and Biophysics (year: 2017, volume: 75, pages: 335-349), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s12013-017-0813-6 – link to the publication

  5. Fluorescent probes for the detection of nitroxyl (HNO).

    Authors:
    Smulik-Izydorczyk Renata, Dębowska Karolina, Pięta Jakub, Michalski Radosław, Marcinek Andrzej, Sikora Adam
    Academic press:
    Free Radical Biology and Medicine (year: 2018, volume: 128, pages: 69-83), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2018.04.564 – link to the publication

  6. Decomposition of Piloty's acid derivatives - Toward the understanding of factors controlling HNO release.

    Authors:
    Smulik-Izydorczyk Renata, Rostkowski Michał, Gerbich Angelika, Jarmoc Dominika, Adamus Jan, Leszczyńska Agnieszka, Michalski Radosław, Marcinek Andrzej, Kramkowski Karol, Sikora Adam
    Academic press:
    Archives of Biochemistry and Biophysics (year: 2019, volume: 661, pages: 132-144), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.abb.2018.11.012 – link to the publication

  7. Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications.

    Authors:
    Zielonka J, Joseph J, Sikora A, Hardy M, Ouari O, Vasquez-Vivar J, Cheng G, Lopez M, Kalyanaraman B.
    Academic press:
    Chemical Reviews (year: 2017, volume: 117, pages: 10043-10120), Publisher: ACS
    Status:
    Published
    DOI:
    10.1021/acs.chemrev.7b00042 – link to the publication

  8. A kinetic study on the reactivity of azanone (HNO) toward its selected scavengers: Insight into its chemistry and detection.

    Authors:
    Smulik-Izydorczyk R, Mesjasz A, Gerbich A, Adamus J, Michalski R, Sikora A.
    Academic press:
    Nitric Oxide (year: 2017, volume: 69, pages: 61-68), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.niox.2017.05.003 – link to the publication

  9. Boronate-Based Probes for Biological Oxidants: A Novel Class of Molecular Tools for Redox Biology

    Authors:
    Sikora A, Zielonka J, Dębowska K, Michalski R, Smulik-Izydorczyk R, Pięta J, Podsiadły R, Artelska A, Pierzchała K, Kalyanaraman B.
    Academic press:
    Frontiers in Chemistry (year: 2020, volume: 8, pages: 580899), Publisher: Frontiers
    Status:
    Published
    DOI:
    10.3389/fchem.2020.580899 – link to the publication

  10. Kinetic Study on the Reactivity of Azanone (HNO) toward Cyclic C-Nucleophiles

    Authors:
    Angelika Artelska, Monika Rola, Michał Rostkowski, Marlena Pięta, Jakub Pięta, Radosław Michalski, Adam Bartłomiej Sikora
    Academic press:
    International journal of molecular sciences (year: 2021, volume: 22, pages: 12982), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222312982 – link to the publication

  11. On the chemical reactivity of tricyanofuran(TCF)-based near-infrared fluorescent redox probes – Effects of glutathione on the probe response and product fluorescence

    Authors:
    Przemysław Siarkiewicz, Radosław Michalski, Adam Sikora, Renata Smulik-Izydorczyk, Marcin Szala, Aleksandra Grzelakowska, Julia Modrzejewska, Asha Bailey, Jacek E. Nycz, Balaraman Kalyanaraman, Jan Grzegorz Malecki, Jacek Zielonka,Radosław Podsiadły
    Academic press:
    Dyes and Pigments (year: 2021, volume: 192, pages: 109405), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.dyepig.2021.109405 – link to the publication

  12. Oxidation of ethidium-based probes by biological radicals: mechanism, kinetics and implications for the detection of superoxide

    Authors:
    Michalski R, Thiebaut D, Michałowski B, Ayhan MM, Hardy M, Ouari O, Rostkowski M, Smulik-Izydorczyk R, Artelska A, Marcinek A, Zielonka J, Kalyanaraman B, Sikora A.
    Academic press:
    Scientific Reports (year: 2020, volume: 10, pages: 18626), Publisher: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-020-75373-2 – link to the publication

  13. Kinetics of Azanone (HNO) Reactions with Thiols: Effect of pH

    Authors:
    Renata Smulik-Izydorczyk, Karolina Dębowska, Michał Rostkowski, Jan Adamus, Radosław Michalski, Adam Sikora
    Academic press:
    Cell biochemistry and biophysics (year: 2021, volume: 79, pages: 845-856), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s12013-021-00986-x – link to the publication

  14. Detection and Characterization of Reactive Oxygen and Nitrogen Species in Biological Systems by Monitoring Species-Specific Products.

    Authors:
    Hardy M, Zielonka J, Karoui H, Sikora A, Michalski R, Podsiadły R, Lopez M, Vasquez-Vivar J, Kalyanaraman B, Ouari O.
    Academic press:
    Antioxidants & Redox Signaling (year: 2018, volume: 28, pages: 1416-1432), Publisher: Mary Ann Liebert, Inc.
    Status:
    Published
    DOI:
    10.1089/ars.2017.7398 – link to the publication

Book publications / chapters in book publications (1)

  1. Identification of Peroxynitrite by Profiling Oxidation and Nitration Products from Mitochondria-Targeted Arylboronic Acid

    Authors:
    Zielonka J, Sikora A, Podsiadly R, Hardy M, Kalyanaraman B
    Book:
    Methods in Molecular Biology Mitochondrial Medicine (year: 2021, volume: 2275, pages: 315-327), Publisher: Springer
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski