Projects funded by the NCN

Fragment-based screening using NMR spectroscopy for the identification of chemical probes that interact with non-canonic...

Call: PRELUDIUM 9 , Panel: ST5

Principal investigator: Katarzyna Kubica

Uniwersytet Jagielloński, Wydział Chemii

2-oxoglutarate dependent oxygenases catalyzing atypical oxidative transformations - structural and mechanistic studies.

Call: OPUS 8 , Panel: NZ1

Principal investigator: prof. Tomasz Borowski

Instytut Katalizy i Fizykochemii Powierzchni im. Jerzego Habera PAN

Structure-function studies of RNA-binding proteins with FAST motifs and a RAP domain.

Call: SONATA 8 , Panel: NZ1

Principal investigator: dr Maria Górna

Uniwersytet Warszawski, Wydział Chemii

Structural biology of mixed lineage leukemia (MLL) proteins

Call: HARMONIA 6 , Panel: NZ5

Principal investigator: prof. Matthias Bochtler

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

2-Oxoglutarate dependent oxygenases in the biosynthesis of pharmacologically active alkaloids - structure, catalytic mec...

Call: SONATA BIS 4 , Panel: NZ1

Principal investigator: prof. Tomasz Borowski

Instytut Katalizy i Fizykochemii Powierzchni im. Jerzego Habera Polskiej Akademii Nauk

Structural and thermodynamic studies of complexes avidin with luminescents and metallocenes biotin derivatives

Call: PRELUDIUM 6 , Panel: ST5

Principal investigator: Paweł Strzelczyk

Politechnika Łódzka, Wydział Biotechnologii i Nauk o Żywności

The active center and beyond: towards new selective inhibitors of S-adenosyl-L-homocysteine hydrolase. Structural enzymo...

Call: OPUS 5 , Panel: NZ1

Principal investigator: dr Krzysztof Brzeziński

Uniwersytet w Białymstoku, Wydział Biologiczno-Chemiczny

Structural basis of biological properties of muscle fructose-1,6-bisphosphatase (FBPase) - a regulatory enzyme of glycon...

Call: OPUS 5 , Panel: NZ1

Principal investigator: prof. Andrzej Dżugaj

Uniwersytet Wrocławski, Wydział Nauk Biologicznych

Structural study of the complexes of hydrolytic enzymes with heteroorganic substrates and substrate analogs

Call: OPUS 3 , Panel: ST4

Principal investigator: dr hab. Jarosław Błaszczyk

Centrum Badań Molekularnych i Makromolekularnych PAN

Structure and function of acireductone dioxygenases - experimental and computational studies.

Call: OPUS 2 , Panel: NZ1

Principal investigator: dr hab. Tomasz Borowski

Instytut Katalizy i Fizykochemii Powierzchni im. Jerzego Habera PAN

Search for novel IKK-β inhibitors in the context of diseases with neuroinflammatory origin – structure-based drug design...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Emilia Sługocka

Uniwersytet Jagielloński, Collegium Medicum

Targeted inhibition of hypusination pathway

Call: OPUS 24 , Panel: NZ7

Principal investigator: dr Przemysław Grudnik

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Mechanisms of cyclization reactions leading to biologically active compounds catalyzed by iron dependent enzymes.

Call: OPUS 23 , Panel: ST4

Principal investigator: prof. Tomasz Borowski

Instytut Katalizy i Fizykochemii Powierzchni im. Jerzego Habera Polskiej Akademii Nauk

Structural and mechanistic studies of replication of (+)ssRNA viruses

Call: OPUS 21 , Panel: NZ1

Principal investigator: prof. Marcin Nowotny

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie

High pressure studies of protein structure on the SOLCRYS beam line at the SOLARIS National Synchrotron Radiation Center

Call: PRELUDIUM BIS 2 , Panel: ST4

Principal investigator: prof. Maciej Kozak

Uniwersytet Jagielloński, Narodowe Centrum Promieniowania Synchrotronowego SOLARIS

Novel L-asparaginases as potential therapeutic agents and antimicrobial targets: structural and functional studies of en...

Call: OPUS 19 , Panel: NZ1

Principal investigator: prof. Mariusz Jaskólski

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Chasing the HARE: elucidation of the binding mechanism of the new and unexplored ligandsof the Hyaluronic Acid Receptor ...

Call: SONATINA 4 , Panel: NZ1

Principal investigator: dr Aleksandra Twarda-Cłapa

Politechnika Łódzka, Wydział Biotechnologii i Nauk o Żywności

The protein with two faces - characterization of a dual-activity deoxyhupusine synthase from Trichomonas vaginalis

Call: PRELUDIUM 18 , Panel: NZ1

Principal investigator: Elżbieta Wątor

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Designer nucleases from a structural and practical point of view

Call: MAESTRO 1 , Panel: NZ1

Principal investigator: prof. Matthias Bochtler

Instytut Biochemii i Biofizyki PAN

Advancing quantum crystallography for better insight into structure and properties of crystals

Call: OPUS 16 , Panel: ST4

Principal investigator: prof. Krzysztof Woźniak

Uniwersytet Warszawski, Wydział Chemii

Histidine Biosynthetic Pathway in Plants: Structural and Functional Studies as a Framework for the Design of Inhibitors ...

Call: SONATA 14 , Panel: NZ1

Principal investigator: dr hab. Miłosz Ruszkowski

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

DEVELOPMENT AND ANALYSIS OF SMALL COMPOUNDS AS CANDIDATE INHIBITORS OF PLANT GROUP A PROTEIN PHOSPHATASES TYPE 2C

Call: SONATA BIS 6 , Panel: NZ3

Principal investigator: dr hab. Agnieszka Ludwików

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

3D structure-based search for selective inhibitor of thymidylate synthase of nematodes, a potential drug in chemotherapy...

Call: OPUS 1 , Panel: NZ6

Principal investigator: prof. Wojciech Rode

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Non-catalytic domains of the RNA-guided DNA methyltransferase DRM2

Call: OPUS 9 , Panel: NZ1

Principal investigator: dr Humberto Fernandes

Instytut Biochemii i Biofizyki PAN