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Fragment-based screening using NMR spectroscopy for the identification of chemical probes that interact with non-canonical ubiquitin-like protein Hub1

2015/17/N/ST5/01942

Keywords:

Hub1 UBL5 NMR spectroscopy chemical probe fragment based screening ubiquitin like protein X-ray crystallography

Descriptors:

  • ST5_16:
  • NZ1_2: Biochemistry

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Jagielloński, Wydział Chemii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Katarzyna Kubica 

Number of co-investigators in the project: 2

Call: PRELUDIUM 9 - announced on 2015-03-16

Amount awarded: 50 000 PLN

Project start date (Y-m-d): 2016-03-03

Project end date (Y-m-d): 2017-03-02

Project duration:: 12 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  1. Computer- and NMR-aided design of small-molecule inhibitors of the Hub1 protein
    Authors:
    Ewa Surmiak, Katarzyna Kubica, Atilio Reyes Romero, Jacek Plewka, Ismael Rodriguez, Katarzyna Magiera-Mularz, Alexander Domling, Tad Holak
    Academic press:
    ChemRxiv (rok: 2022, tom: brak, strony: brak), Wydawca: Cambridge University Press co-owned by American Chemical Society (ACS), Chinese Chemical Society (CCS), Chemical Society of Japan (CSJ), German Chemical Society (GDCh), Royal Society of Chemistry (RSC)
    Status:
    Published
    DOI:
    10.26434/chemrxiv-2022-7859b - link to the publication
  2. Computer- and NMR-Aided Design of Small-Molecule Inhibitors of the Hub1 Protein
    Authors:
    Atilio Reyes Romero, Katarzyna Kubica, Radoslaw Kitel, Ismael Rodriquez, Katarzyna Magiera-Mularz, Alexander Dӧmling, Tad A. Holak and Ewa Surmiak
    Academic press:
    Molecules (rok: 2022, tom: 27, strony: brak (1-15)), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules27238282 - link to the publication

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