Projects funded by the NCN
Structural biology of mixed lineage leukemia (MLL) proteins
2014/14/M/NZ5/00558
Keywords:
MLL leukemia protein crystallography
Descriptors:
- NZ5_1: Etiology of human diseases
- NZ1_4: Structural biology
- NZ1_2: Biochemistry
Panel:
NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)
Host institution :
Międzynarodowy Instytut Biologii Molekularnej i Komórkowej
woj. mazowieckie
Principal investigator (from the host institution):
Number of co-investigators in the project: 8
Call: HARMONIA 6 - announced on 2014-06-16
Amount awarded: 1 255 000 PLN
Project start date (Y-m-d): 2015-06-08
Project end date (Y-m-d): 2019-06-07
Project duration:: 48 months (the same as in the proposal)
Project status: Project settled
Information in the final report
- Publication in academic press/journals (2)
- Clustered PHD domains in KMT2/MLL proteins are attracted by H3K4me3 and H3 acetylation-rich active promoters and enhancersAuthors:Anna Maria Stroynowska-Czerwinska, Magdalena Klimczak, Michal Pastor, Asgar Abbas Kazrani, Katarzyna Misztal, Matthias BochtlerAcademic press:Cellular and Molecular Life Sciences (rok: 2023, tom: 3,34930555555556, strony: 45313), Wydawca: Springer Science+Business MediaStatus:PublishedDOI:10.1007/s00018-022-04651-1 - link to the publication
- Specificity of MLL1 and TET3 CXXC domains towards naturally occurring cytosine modifications.Authors:Stroynowska-Czerwinska A, Piasecka A, Bochtler MAcademic press:Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms (rok: 2018, tom: 1861 (12), strony: 1093-1101), Wydawca: Elsevier Ltd.Status:PublishedDOI:10.009 - link to the publication