Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Structural studies on inhibition mechanisms of enzymes belonging to USP family, which remove ubiquitin from eukaryotic proteins

2017/24/C/NZ1/00366

Keywords:

ubiquitin enzyme inhibition oncogenesis X-ray crystallography

Descriptors:

  • NZ1_4:
  • NZ1_2:
  • NZ7_16:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Warszawski, Wydział Chemii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marcin Jarosław Ziemniak 

Number of co-investigators in the project: 2

Call: SONATINA 1 - announced on 2016-12-15

Amount awarded: 1 044 097 PLN

Project start date (Y-m-d): 2017-12-13

Project end date (Y-m-d): 2022-12-12

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  1. 2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents
    Authors:
    B. Pajak, E. Siwiak, M. Sołtyka, A. Priebe, R. Zieliński, I. Fokt, M. Ziemniak, A. Jaśkiewicz, R. Borowski, T. Domoradzki, W. Priebe
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 45676), Wydawca: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/ijms21010234 - link to the publication
  2. Computational analysis of energetic features and intermolecular interactions in protein-inhibitor USP7 complexes
    Authors:
    Marcin Ziemniak, Urszula Budniak, Paulina Maria Dominiak, Krzysztof Woźniak
    Academic press:
    RSC Advances , Wydawca: Royal Society of Chemistry
    Status:
    Submitted
    DOI:
    brak - link to the publication
  3. X-ray wavefunction refinement and comprehensive structural studies on bromo-substituted analogues of 2-deoxy-d-glucose in solid state and solution
    Authors:
    M. Ziemniak, S. Pawlędzio, A. Zawadzka-Kazimierczuk, P. M. Dominiak, D. Trzybiński, W. Koźmiński, I. Fokt, W. Priebe, K. Woźniak, B. Pająk
    Academic press:
    RSC Advances (rok: 2022, tom: 12, strony: 8345-8360), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D1RA08312K - link to the publication
  4. Experimental and Computational Studies on Structure and Energetic Properties of Halogen Derivatives of 2-Deoxy-D-Glucose
    Authors:
    M. Ziemniak, A. Zawadzka-Kazimierczuk, S. Pawlędzio, M. Malinska, M. Sołtyka, D. Trzybiński, W. Koźmiński, S. Skora, R. Zieliński, I. Fokt, W. Priebe, K. Woźniak, B. Pająk
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 45678), Wydawca: Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/ijms22073720 - link to the publication
  5. D-Glucose- and D-mannose-based antimetabolites. Part 4: Facile synthesis of mono- and di-acetates of 2-deoxy-D-glucose prodrugs as potentially useful antimetabolites
    Authors:
    Izabela Fokt, Marcin Cybulski, Stanislaw Skora, Beata Pająk, Marcin Ziemniak, Krzysztof Woźniak, Waldemar Priebe
    Academic press:
    Carbohydrate Research (rok: 2023, tom: 531, strony: 108861-108872), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.carres.2023.108861 - link to the publication

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