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Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Structural basis of biological properties of muscle fructose-1,6-bisphosphatase (FBPase) - a regulatory enzyme of glyconeogenesis and multifunctonal protein involved in protection of mitochondria nad regulation of cell cycle.

2013/09/B/NZ1/01081

Keywords:

crystallography NMR protein-protein interaction molecular modeling enzyme kinetics glyconeogenesis subcellular localization multifunctional proteins

Descriptors:

  • NZ1_4: Structural biology
  • NZ1_1: Molecular biology
  • NZ1_2: Biochemistry

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Wrocławski, Wydział Nauk Biologicznych

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Andrzej Dżugaj 

Number of co-investigators in the project: 9

Call: OPUS 5 - announced on 2013-03-15

Amount awarded: 877 960 PLN

Project start date (Y-m-d): 2014-03-07

Project end date (Y-m-d): 2017-12-06

Project duration:: 45 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. autoklaw (25 000 PLN)
  2. termocykle (30 000 PLN)
  3. naczynie Dawer (3 936 PLN)
  4. stacje graficzne (3 szt.) (18 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. T-to-R switch of muscle fructose-1,6-bisphosphatase involves fundamental changes of secondary and quaternary structure
    Authors:
    Barciszewski J, Wisniewski J, Kolodziejczyk R, Jaskolski M, Rakus D and Dzugaj A
    Academic press:
    Acta Cryst. D (rok: 2016, tom: 72(Pt 4), strony: 536-50), Wydawca: International Union of Crystallography
    Status:
    Published
    DOI:
    10.1107/S2059798316001765 - link to the publication
  2. Proteomics Unveils Fibroblast-Cardiomyocyte Lactate Shuttle and Hexokinase Paradox in Mouse Muscles
    Authors:
    Rakus D, Gizak A, Wiśniewski JR
    Academic press:
    J Proteome Res. (rok: 2016, tom: 15(8), strony: 2479-90), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.jproteome.5b01149 - link to the publication
  3. Dimeric and tetrameric forms of muscle fructose-1,6-bisphosphatase play different roles in the cell.
    Authors:
    Wiśniewski J, Piróg M, Hołubowicz R, Dobryszycki P, McCubrey JA, Rakus D, Gizak A.
    Academic press:
    Oncotarget (rok: 2017, tom: 8, strony: 115420-115433), Wydawca: Impact Journals, LCC
    Status:
    Published
    DOI:
    10.18632/oncotarget.23271 - link to the publication

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