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Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Structure and function of acireductone dioxygenases - experimental and computational studies.

2011/03/B/NZ1/04999

Keywords:

amino acid biosynthesis dioxygenase metalloenzyme reaction mechanism spectroscopy protein crystallography modelling

Descriptors:

  • NZ1_2: Biochemistry
  • NZ1_4: Structural biology
  • ST4_15: Colloid chemistry

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Katalizy i Fizykochemii Powierzchni im. Jerzego Habera PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Tomasz Borowski 

Number of co-investigators in the project: 6

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 248 100 PLN

Project start date (Y-m-d): 2012-08-02

Project end date (Y-m-d): 2016-02-01

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Pompa próżniowa (10 000 PLN)
  2. Chłodziarka (2 500 PLN)
  3. Elektroda tlenowa Clark'a (6 500 PLN)
  4. Preparatywna kolumna ze złożem niklowym do chromatografii HPLC (6 000 PLN)
  5. Suchy dewar do transportu próbek (18 000 PLN)
  6. Zestaw pipet automatycznych.
  7. Cieplarko-wytrząsarka (27 000 PLN)
  8. Płytka do pomiaru absorbancji w szerokim zakresie objętości próbek.
  9. Zasilacz do aparatu do elektroforezy.

Information in the final report

  • Publication in academic press/journals (4)
  1. Anion effects in oxidative aliphatic carbon-carbon bond cleavage reactions of Cu(II) chlorodiketonate complexes.
    Authors:
    S.L. Saraf, A. Miłaczewska, T. Borowski, C.D. James, D.L. Tierney, M. Popova, A.M. Arif, L.M. Berreau
    Academic press:
    Inorganic Chemistry (rok: 2016, tom: 55, strony: 6916-6928), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.6b00456 - link to the publication
  2. DFT study of the mechanism of manganese quercetin 2,3-dioxygenase: quest for origins of enzyme unique nitroxygenase activity and regioselectivity
    Authors:
    Z. Wojdyła, T. Borowski
    Academic press:
    Journal of Biological Inorganic Chemistry (rok: 2016, tom: 21, strony: 475-489), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00775-016-1356-9 - link to the publication
  3. Halide-promoted dioxygenolysis of a carbon-carbon bond by a copper(II) diketonate complex.
    Authors:
    C.J. Allpress, A. Miłaczewska, T. Borowski, J.R. Bennett, D.L. Tierney, A.M. Arif, L.M. Berreau
    Academic press:
    Journal of the American Chemical Society (rok: 2014, tom: 136, strony: 7821-7824), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/ja502577b - link to the publication
  4. Synthesis and crystal structure of dimeric 1-hydroxyhexane-2,3- dione and spectral characteristics of a model acireductone
    Authors:
    B. Trzewik, K. Chruszcz-Lipska, A. Miłaczewska, J. Opalińska-Piskorz, R. Karcz, R. Gryboś, M. Oszajca, K. Luberda-Durnaś, W. Łasocha, A. Fitch, B. Sulikowski, T. Borowski
    Academic press:
    New Journal of Chemistry (rok: 2016, tom: 40, strony: 9291-9303), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c6nj00562d - link to the publication

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