Projects funded by the NCN

Dissecting mechanisms of RNA-based Stress Granules formation, their structure and role in the development of Multi-Drug ...

Call: OPUS 9 , Panel: NZ7

Principal investigator: dr hab. Witold Szaflarski

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Medyczny

Fragment-based screening using NMR spectroscopy for the identification of chemical probes that interact with non-canonic...

Call: PRELUDIUM 9 , Panel: ST5

Principal investigator: Katarzyna Kubica

Uniwersytet Jagielloński, Wydział Chemii

Synthesis of fluorogenic substrates, inhibitors and activity-based probes of human neutrophil proteinase NSP4 and its ev...

Call: OPUS 8 , Panel: ST5

Principal investigator: prof. Adam Lesner

Uniwersytet Gdański, Wydział Chemii

The influence of bone marrow microenvironment on the regulation of BRCA1 mRNA translation in leukemia cells; role in the...

Call: SONATA 8 , Panel: NZ3

Principal investigator: dr Paulina Podszywałow-Bartnicka

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Identification of proteins locally synthesized at the synapse in response to neuronal stimulation in physiology and frag...

Call: SONATA BIS 4 , Panel: NZ3

Principal investigator: dr hab. Magdalena Dziembowska

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Design and synthesis of probes for RabGGTase profiling and their application for identification of the site of phosphono...

Call: SONATA BIS 4 , Panel: ST5

Principal investigator: dr hab. Katarzyna Błażewska

Politechnika Łódzka, Wydział Chemiczny

Enzymatic catalysis as a versatile tool for the synthesis of 1,3-dimethylxanthine derivatives with potential anticancer ...

Call: PRELUDIUM 7 , Panel: ST5

Principal investigator: dr Paweł Borowiecki

Politechnika Warszawska, Politechnika Warszawska

Tailored fluorogenic substrate library with natural / unnatural amino acids in search for specific substrates of matrix ...

Call: OPUS 7 , Panel: ST5

Principal investigator: dr hab. Marcin Drąg

Politechnika Wrocławska, Wydział Chemiczny

Design, chemical synthesis and biological activity of inhibitors of matriptase-2.

Call: PRELUDIUM 7 , Panel: ST5

Principal investigator: Agata Gitlin-Domagalska

Uniwersytet Gdański, Wydział Chemii

Coupling of synthesis and transport for proteins targeted to the mitochondria

Call: OPUS 6 , Panel: NZ3

Principal investigator: prof. Agnieszka Chacińska

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Structural and thermodynamic studies of complexes avidin with luminescents and metallocenes biotin derivatives

Call: PRELUDIUM 6 , Panel: ST5

Principal investigator: Paweł Strzelczyk

Politechnika Łódzka, Wydział Biotechnologii i Nauk o Żywności

Chemical sensors for selective determination of chosen amino acids of gluten proteins using molecularly imprinted polyme...

Call: PRELUDIUM 6 , Panel: ST5

Principal investigator: dr Zofia Iskierko

Instytut Chemii Fizycznej PAN

Crystallographic investigation of mammalian serum albumins in complexes with ligands

Call: OPUS 6 , Panel: ST5

Principal investigator: dr Anna Bujacz

Politechnika Łódzka, Wydział Biotechnologii i Nauk o Żywności

A development of a method of micro-scale synthesis of peptides labelled with stable isotopes for quantitative proteomics

Call: PRELUDIUM 6 , Panel: ST4

Principal investigator: Maciej Modzel

Uniwersytet Wrocławski, Wydział Chemii

Synthesis and application of new biarsenical sensors and platforms for selective and multifunctional modification of pro...

Call: OPUS 1 , Panel: ST5

Principal investigator: dr hab. Artur Krężel

Uniwersytet Wrocławski, Wydział Biotechnologii

Multicomponent polymer films towards fabrication of multiprotein patterns

Call: SONATA 5 , Panel: ST5

Principal investigator: dr Joanna Zemła

Uniwersytet Jagielloński, Wydział Fizyki, Astronomii i Informatyki Stosowanej

Synthesis and biological evaluation of pyrrolidine-2,5-dione derivatives as potential antidepressant agents.

Call: OPUS 5 , Panel: NZ7

Principal investigator: dr Andrzej Chodkowski

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Simulation of conformational changes related to the interdomain communication in the eukaryotic GlcN-6-P synthase by mea...

Call: PRELUDIUM 5 , Panel: NZ2

Principal investigator: Aleksandra Miszkiel

Politechnika Gdańska, Wydział Chemiczny

Design and synthesis of acylpeptide hydrolase inhibitors as potential inducers of apoptosis in tumor cells

Call: PRELUDIUM 5 , Panel: ST5

Principal investigator: Maciej Walczak

Politechnika Wrocławska, Wydział Chemiczny

Design and synthesis of selective and irreversible inhibitors of HAT protease.

Call: PRELUDIUM 5 , Panel: ST5

Principal investigator: Marcin Skoreński

Politechnika Wrocławska, Wydział Chemiczny

Synthetic, new generation layers to interact with the liquid connective tissue

Call: OPUS 5 , Panel: ST8

Principal investigator: dr hab. Aleksandra Wesełucha-Birczyńska

Uniwersytet Jagielloński, Wydział Chemii

Electrospinning of bicomponent nanofibers - synthetic polymer/biopolymer using alternative, protein non-denaturing, nonc...

Call: OPUS 5 , Panel: ST8

Principal investigator: dr hab. Paweł Sajkiewicz

Instytut Podstawowych Problemów Techniki PAN

Unnatural amino acids as a tool for optimization of substrates architecture for targeting human cysteine protease, cathe...

Call: PRELUDIUM 5 , Panel: ST5

Principal investigator: dr Marcin Poręba

Politechnika Wrocławska, Wydział Chemiczny

Designing mRNA transcripts resistant to enzymatic cap hydrolysis applicable for anti-cancer vaccines; multiplexed bioche...

Call: MAESTRO 4 , Panel: NZ1

Principal investigator: prof. Edward Darżynkiewicz

Uniwersytet Warszawski, Centrum Nowych Technologii

Synthesis and application of chiral bicyclic proline's derivatives for the synthesis of enantiodifferenting, traceless, ...

Call: PRELUDIUM 4 , Panel: ST5

Principal investigator: dr Katarzyna Kasperowicz-Frankowska

Politechnika Łódzka, Wydział Chemiczny

Fluorescent substrates of neutrophil proteinases: design, chemical synthesis , selection by the combinatorial chemistry ...

Call: PRELUDIUM 4 , Panel: ST5

Principal investigator: dr Jadwiga Popow - Stellmaszyk

Uniwersytet Gdański, Wydział Chemii

Electrokinetic characteristics of interaction between recombinant HSA monolayers and ionic ligands

Call: PRELUDIUM 4 , Panel: ST5

Principal investigator: Marta Kujda

Instytut Katalizy i Fizykochemii Powierzchni im. Jerzego Habera PAN

Exploration of new polyheterocyclic, chiral compounds containing pyrrolidine and imidazole rings in asymmetric synthesis...

Call: PRELUDIUM 4 , Panel: ST5

Principal investigator: Aneta Wróblewska

Uniwersytet Łódzki, Wydział Chemii

Members of eIF4E protein family, their affinities towards 5' mRNA cap and protein binding partners: an interdisciplinary...

Call: OPUS 4 , Panel: NZ1

Principal investigator: prof. Edward Darżynkiewicz

Uniwersytet Warszawski, Wydział Fizyki

Structure and properties of protein layers: from biomolecules to a functional layer (a combined experimental and simulat...

Call: OPUS 4 , Panel: ST5

Principal investigator: dr hab. Barbara Jachimska

Instytut Katalizy i Fizykochemii Powierzchni im. Jerzego Habera PAN

Synthesis of protein fragments of pathogens mimics human proteins and their use in diagnosis and prognosis of rheumatoid...

Call: PRELUDIUM 3 , Panel: ST5

Principal investigator: Inga Relich

Politechnika Łódzka, Wydział Chemiczny

New beta-lactoglobulin variants with increased affinity to selected highly toxic drugs

Call: OPUS 3 , Panel: ST5

Principal investigator: prof. Krzysztof Lewiński

Uniwersytet Jagielloński, Wydział Chemii

New reagents and methods in synthesis of modified nucleotides and their application for preparation biochemical tools an...

Call: SONATA BIS 1 , Panel: ST5

Principal investigator: dr hab. Jacek Jemielity

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Structural and functional characterization of peptidyl prolyl isomerases - universally conserved protein folding catalys...

Call: OPUS 2 , Panel: NZ1

Principal investigator: prof. Satish Raina

Politechnika Gdańska, Wydział Chemiczny

Peptide splicing - the mechanism and its application for designing compounds with potential use in medicinal practice

Call: OPUS 1 , Panel: ST5

Principal investigator: prof. Krzysztof Rolka

Uniwersytet Gdański, Wydział Chemii

Thrombotic Mechanisms in Human Cystathionine β-Synthase Deficiency

Call: OPUS 1 , Panel: NZ1

Principal investigator: prof. Hieronim Jakubowski

Instytut Chemii Bioorganicznej PAN

Investigation of histidine phosphorylation in thymidylate synthase and searching for causative protein kinase

Call: OPUS 2 , Panel: NZ1

Principal investigator: dr hab. Joanna Cieśla

POLITECHNIKA WARSZAWSKA

Theoretical prediction, chemical synthesis and biological analysis of a novel class of HSPA5 inhibitors

Call: OPUS 25 , Panel: ST4

Principal investigator: prof. Arkadiusz Chworoś

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

Development of Three Model Single- or Multi-Layer Extract/Polysaccharide/Protein/Oil Coating Systems and Their Physico-C...

Call: PRELUDIUM 22 , Panel: ST5

Principal investigator: Wiktoria Grzebieniarz

Uniwersytet Rolniczy im. Hugona Kołłątaja w Krakowie, Wydział Technologii Żywności

Regulacja procesu deoksyhypuzynacji przez kinazy białkowe

Call: PRELUDIUM 22 , Panel: NZ1

Principal investigator: Paweł Kochanowski

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Protein immobilisation to film surfaces and micro-patterns of conjugated polymer in the aspect of biosensors application...

Call: PRELUDIUM 2 , Panel: ST5

Principal investigator: dr Kamil Awsiuk

Uniwersytet Jagielloński, Wydział Fizyki, Astronomii i Informatyki Stosowanej

Impact of metal and metal oxide nanoparticle functionalization by low-molar mass polyphenols on their activity in protei...

Call: PRELUDIUM BIS 4 , Panel: ST5

Principal investigator: dr hab. Magdalena Oćwieja

Instytut Katalizy i Fizykochemii Powierzchni im. Jerzego Habera Polskiej Akademii Nauk

Redox polymers combined with electrochemically assisted SPR – mechanism of response and sensitive sensing

Call: OPUS 24 , Panel: ST5

Principal investigator: dr Maciej Cieplak

Instytut Chemii Fizycznej Polskiej Akademii Nauk

Development and characterization of a novel bioink for fabrication of 3D printed bioartificial pulsatile prosthesis for ...

Call: SONATA 18 , Panel: ST5

Principal investigator: dr Jagoda Litowczenko-Cybulska

Uniwersytet im. Adama Mickiewicza w Poznaniu, Centrum NanoBioMedyczne

Sepsis biomarkers sensitive and selective sensor by functional UiO-68 MOF@MXene composite electrode

Call: POLONEZ BIS 3 , Panel: ST5

Principal investigator: dr Ranjith Kumar Deivasigamani

Politechnika Śląska, Centrum Elektroniki Organicznej i Nanohybrydowej

Thermodynamic contribution of halogen bonds in protein-ligand systems. Design, synthesis, and thermodynamic studies of m...

Call: PRELUDIUM 21 , Panel: ST4

Principal investigator: Sławomir Kasperowicz

Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

Blocking interactions between Rab1b and Rab5 proteins and their negative regulators TBC1D20 and TBC1D17 with synthetic p...

Call: PRELUDIUM BIS 3 , Panel: NZ1

Principal investigator: dr hab. Edyta Gendaszewska-Darmach

Politechnika Łódzka, Wydział Biotechnologii i Nauk o Żywności

Structure and Function of Protein Corona at the Nanoparticles Interface

Call: OPUS 21 , Panel: ST5

Principal investigator: prof. Barbara Jachimska

Instytut Katalizy i Fizykochemii Powierzchni im. Jerzego Habera Polskiej Akademii Nauk

The impact of UPF1 ATP mimetics on the mutant immunopeptidome

Call: OPUS 20 , Panel: NZ7

Principal investigator: prof. Theodore Hupp

Uniwersytet Gdański, Międzynarodowe Centrum Badań nad Szczepionkami Przeciwnowotworowymi

Mechanisms controlling endocytosis of CD14 as targets for regulation of inflammatory responses of macrophages

Call: OPUS 20 , Panel: NZ3

Principal investigator: dr Anna Ciesielska

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk