Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Can Fusobacterium nucleatum adhesion proteins increase prooxidative activity of iron and copper ions?

2014/13/B/ST5/04359

Keywords:

metal ion coordination iron(II III) copper(I II) reactive oxygen species oxidative damages of biomolecules peptide synthesis Fusobacterium nucleatum colon cancer adhezins

Descriptors:

  • ST5_14: Other related subjects
  • ST5_16:
  • ST5_23:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Wrocławski, Wydział Chemii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Kamila Stokowa-Sołtys 

Number of co-investigators in the project: 7

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 830 000 PLN

Project start date (Y-m-d): 2015-02-12

Project end date (Y-m-d): 2019-02-11

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Spektrometr UV-Vis z termostatowanym statywem na kuwety i sondami światłowod (160 000 PLN)
  2. System do oczyszczania wody (30 000 PLN)
  3. Zestaw do miareczkowania potencjometrycznego (70 000 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  1. Białka błony zewnętrznej Fusobacterium nucleatum jako potencjalny czynnik promocji nowotworu jelita grubego
    Authors:
    Monika K. Lesiów, Katarzyna Krupa, Urszula K. Komarnicka, Paulina K. Walencik
    Academic press:
    Wiadomości Chemiczne (rok: 2018, tom: 72, strony: 585-596), Wydawca: Polskie Towarzystwo Chemiczne
    Status:
    Published
  2. Fusobacterium nucleatum – friend or enemy?
    Authors:
    Kamil Wojtkowiak, Karolina Jagiełło, Kamila Stokowa-Sołtys
    Academic press:
    European Journal of Medicinal Chemistry , Wydawca: Elsevier
    Status:
    Submitted
  3. Phleomycin complex - Coordination mode and in vitro cleavage of DNA.
    Authors:
    Kamila Stokowa-Sołtys, Valentyn Dzyhovskyi, Robert Wieczorek, Małgorzata Jeżowska-Bojczuk
    Academic press:
    Journal of Inorganic Biochemistry (rok: 2019, tom: 195, strony: 71-82), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2019.03.010 - link to the publication
  4. Copper(II) complexes with Fusobacterium nucleatum adhesin FadA: Coordination pattern, physicochemical properties and reactivity
    Authors:
    Katarzyna Krupa, Monika Lesiów, Kamila Stokowa-Sołtys, Radosław Starosta, Natalia Ptaszyńska, Anna Łęgowska, Krzysztof Rolka, Maciej Wernecki, Magdalena Cal, Małgorzata Jeżowska-Bojczuk
    Academic press:
    Journal of Inorganic Biochemistry (rok: 2018, tom: 189, strony: 69-80), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2018.09.012 - link to the publication
  5. Peptides having antimicrobial activity and their complexes with transition metal ions
    Authors:
    Małgorzata Jeżowska-Bojczuk, Kamila Stokowa-Sołtys
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2018, tom: 1;143, strony: 997-1009), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2017.11.086 - link to the publication
  6. Protocol of proceedings with Fusobacterium nucleatum and optimization of ABTS method for detection of reactive oxygen species.
    Authors:
    Anna Kędziora, Monika Lesiów, Katarzyna Krupa, Agnieszka Korzeniowska-Kowal, Ryszard Adamski, Urszula Komarnicka, Kamila Stokowa-Sołtys, Małgorzata Jeżowska-Bojczuk, Gabriela Bugla-Płoskońska
    Academic press:
    Future Microbiology , Wydawca: Future Science Group
    Status:
    Accepted for publication
  7. Antybiotyki peptydowe i ich kompleksy z jonami metali
    Authors:
    Kamila Stokowa-Sołtys
    Academic press:
    Wiadomości Chemiczne (rok: 2018, tom: 72, strony: 497-522), Wydawca: Polskie Towarzystwo Chemiczne
    Status:
    Published
  8. Relationship between copper(II) complexes with FomA adhesin fragments of F. nucleatum and colorectal cancer. Coordination pattern and ability to promote ROS production.
    Authors:
    M. K. Lesiów, U. K. Komarnicka, K. Stokowa-Sołtys, K. Rolka, A. Łęgowska, N. Ptaszyńska, R. Wieczorek, A. Kyzioł, and M. Jeżowska-Bojczuk
    Academic press:
    Dalton Transactions (rok: 2018, tom: 47, strony: 5445-5458), Wydawca: RSC Publishing - Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C7DT04103A - link to the publication