Can Fusobacterium nucleatum adhesion proteins increase prooxidative activity of iron and copper ions?

2014/13/B/ST5/04359

Keywords

Descriptors

  • ST5_14: Chemia koordynacyjna
  • ST5_16: Chemia biologiczna
  • ST5_23: Chemia organiczna

Panel

ST5 – Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution

Uniwersytet Wrocławski, Wydział Chemii

Voivodeship: dolnośląskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Kamila Kamila Stokowa-Sołtys

Number of co-investigators in the project: 7

Call

OPUS 7 – announced on 2014-03-17

Amount awarded
830 000 PLN
Project start date
2015-02-12
Project end date
2019-02-11
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Spektrometr UV-Vis z termostatowanym statywem na kuwety i sondami światłowod. Cost: 160 000 PLN
  2. System do oczyszczania wody. Cost: 30 000 PLN
  3. Zestaw do miareczkowania potencjometrycznego. Cost: 70 000 PLN

Information in the final report

Publication in academic press/journals (7)

  1. Białka błony zewnętrznej Fusobacterium nucleatum jako potencjalny czynnik promocji nowotworu jelita grubego

    Authors:
    Monika K. Lesiów, Katarzyna Krupa, Urszula K. Komarnicka, Paulina K. Walencik
    Academic press:
    Wiadomości Chemiczne (year: 2018, volume: 72, pages: 585-596), Publisher: Polskie Towarzystwo Chemiczne
    Status:
    Published
  2. Copper(II) complexes with Fusobacterium nucleatum adhesin FadA: Coordination pattern, physicochemical properties and reactivity

    Authors:
    Katarzyna Krupa, Monika Lesiów, Kamila Stokowa-Sołtys, Radosław Starosta, Natalia Ptaszyńska, Anna Łęgowska, Krzysztof Rolka, Maciej Wernecki, Magdalena Cal, Małgorzata Jeżowska-Bojczuk
    Academic press:
    Journal of Inorganic Biochemistry (year: 2018, volume: 189, pages: 69-80), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2018.09.012 – link to the publication
  3. Relationship between copper(II) complexes with FomA adhesin fragments of F. nucleatum and colorectal cancer. Coordination pattern and ability to promote ROS production.

    Authors:
    M. K. Lesiów, U. K. Komarnicka, K. Stokowa-Sołtys, K. Rolka, A. Łęgowska, N. Ptaszyńska, R. Wieczorek, A. Kyzioł, and M. Jeżowska-Bojczuk
    Academic press:
    Dalton Transactions (year: 2018, volume: 47, pages: 5445-5458), Publisher: RSC Publishing - Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C7DT04103A – link to the publication
  4. Phleomycin complex - Coordination mode and in vitro cleavage of DNA.

    Authors:
    Kamila Stokowa-Sołtys, Valentyn Dzyhovskyi, Robert Wieczorek, Małgorzata Jeżowska-Bojczuk
    Academic press:
    Journal of Inorganic Biochemistry (year: 2019, volume: 195, pages: 71-82), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2019.03.010 – link to the publication
  5. Peptides having antimicrobial activity and their complexes with transition metal ions

    Authors:
    Małgorzata Jeżowska-Bojczuk, Kamila Stokowa-Sołtys
    Academic press:
    European Journal of Medicinal Chemistry (year: 2018, volume: 1;143, pages: 997-1009), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2017.11.086 – link to the publication
  6. Antybiotyki peptydowe i ich kompleksy z jonami metali

    Authors:
    Kamila Stokowa-Sołtys
    Academic press:
    Wiadomości Chemiczne (year: 2018, volume: 72, pages: 497-522), Publisher: Polskie Towarzystwo Chemiczne
    Status:
    Published
  7. Protocol of proceedings with Fusobacterium nucleatum and optimization of ABTS method for detection of reactive oxygen species.

    Authors:
    Anna Kędziora, Monika Lesiów, Katarzyna Krupa, Agnieszka Korzeniowska-Kowal, Ryszard Adamski, Urszula Komarnicka, Kamila Stokowa-Sołtys, Małgorzata Jeżowska-Bojczuk, Gabriela Bugla-Płoskońska
    Status:
    Accepted for publication

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Graphic design and implementation: Jakub Piotrowski