Projects funded by the NCN
Dissecting mechanisms of RNA-based Stress Granules formation, their structure and role in the development of Multi-Drug Resistance in cancer cells
2015/17/B/NZ7/03043
Keywords:
Stress Granules initiation of protein synthesis Multi-Drug Resistance
Descriptors:
- NZ7_15: Toxicology
- NZ7_14: Pharmacy, pharmacotherapy, pharmacology
- NZ1_1: Molecular biology
Panel:
NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution :
Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Medyczny
woj. wielkopolskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 2
Call: OPUS 9 - announced on 2015-03-16
Amount awarded: 997 200 PLN
Project start date (Y-m-d): 2016-01-21
Project end date (Y-m-d): 2022-01-20
Project duration:: 72 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Automatyczny licznik komórek.
- Cytometr przepływowy.
- Automatyczna barwiarka do preparatów histologicznych.
- Komputer graficzny z wysoką rozdzielczością monitora (12 000 PLN)
- System dokumentacji fotograficznej żeli (165 000 PLN)
- System detekcji białek w membranach westren-blot (5 000 PLN)
- Inkubator CO2.
- Piec do hybrydyzacji RNA (16 000 PLN)
Information in the final report
- Publication in academic press/journals (2)
- Translation inhibition and suppression of stress granules formation by cisplatinAuthors:Pietras P, Aulas A, Fay MM, Leśniczak-Staszak M, Sowiński M, Lyons SM, Szaflarski W, Ivanov PAcademic press:Biomedicine & Pharmacotherapy (rok: 2022, tom: 145, strony: 112382), Wydawca: ELSEVIERStatus:PublishedDOI:10.1016/j.biopha.2021.112382 - link to the publication
- Early rRNA processing is a stress-dependent regulatory event whose inhibition maintains nucleolar integrityAuthors:Szaflarski W, Leśniczak-Staszak M, Sowiński M, Ojha S, Aulas A, Dave D, Malla S, Anderson P, Ivanov P, Lyons SMAcademic press:Nucleic Acids Research (rok: 2022, tom: 50(2), strony: 1033-1051), Wydawca: Oxford AcademicStatus:PublishedDOI:10.1093/nar/gkab1231 - link to the publication