Mechanisms protecting from oxidative damage during aging

2015/19/B/NZ1/03444

Keywords

Descriptors

NZ1_2: Biochemia
NZ1_1: Biologia molekularna
NZ3_4: Starzenie

Panel

NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution

Instytut Biochemii i Biofizyki PAN

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Ulrike Topf

Number of co-investigators in the project: 3

Call

OPUS 10 – announced on 2015-09-15

Amount awarded: 1 200 800 PLN
Project start date: 2016-09-30
Project end date: 2020-11-29
Project duration: 50 months (the same as in the proposal)
Project status: Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

Aparat do elektroforezy. Cost: 2 600 PLN
Kaseta do odczytu wyznakowanych białek. Cost: 12 500 PLN
Komputery (2 pcs). Cost: 16 500 PLN
Pompa próżniowa. Cost: 8 100 PLN
Suszarka do żeli poliakrylamidowych. Cost: 11 500 PLN
Termomikser.
Zamrażarka -20. Cost: 3 000 PLN
Zasilacz do elektroforezy (2 szt.).

Information in the final report

Publication in academic press/journals (7)

Loss of the Mia40a oxidoreductase leads to hepato-pancreatic insufficiency in zebrafish

Authors:
Sokol A.M., Uszczynska-Ratajczak B., Collins M.M., Bazala M., Topf U., Lundegaard P.R., Sugunan S., Guenther S., Kuenne C., Graumann J., Chan S.S.L., Stainier D.Y.R., Chacinska A.

Academic press:
PLOS Genetics (year: 2018, volume: 14(11), pages: e1007743), Publisher: Public Library of Science

Status:
Published

DOI:
10.1371/journal.pgen.1007743 – link to the publication
Mitochondrial stress-dependent regulation of cellular protein synthesis

Authors:
Topf U., Uszczynska-Ratajczak B., Chacinska A.

Academic press:
Journal of Cell Science (year: 2019, volume: 8, pages: jcs226258), Publisher: The Company of Biologists

Status:
Published

DOI:
10.1242/jcs.226258 – link to the publication
The evolving role of ribosomes in the regulation of protein synthesis

Authors:
Karolina Gościńska, Ulrike Topf

Academic press:
Acta Biochim Pol (year: 2020, volume: 67, pages: 5384), Publisher: Acta Biochim Pol

Status:
Published

DOI:
10.18388/abp.2020_5384 – link to the publication
Eukaryotic Elongation Factor 3 Protects Saccharomyces cerevisiae Yeast from Oxidative Stress

Authors:
Karolina Gościńska, Somayeh Shahmoradi Ghahe, Sara Domogała, Ulrike Topf

Academic press:
Genes (Basel) (year: 2020, volume: 11(12), pages: 1432), Publisher: MDPI

Status:
Published

DOI:
10.3390/genes11121432 – link to the publication
Proteasome activity contributes to pro-survival response upon mild mitochondrial stress in Caenorhabditis elegans

Authors:
Maria Sladowska, Michał Turek, Min-Ji Kim, Krzysztof Drabikowski, Ben Hur Marins Mussulini, Karthik Mohanraj, Remigiusz A Serwa, Ulrike Topf, Agnieszka Chacinska

Academic press:
PLoS Biology (year: 2021, volume: 19(7), pages: e3001302), Publisher: Public Library of Science

Status:
Published

DOI:
10.1371/journal.pbio.3001302 – link to the publication
Ancient function of teneurins in tissue organization and neuronal guidance in the nematode Caenorhabditis elegans

Authors:
Topf U. and Drabikowski K.

Academic press:
Frontiers in Neuroscience (year: 2019, volume: 13, pages: NA), Publisher: Frontiers Media SA

Status:
Published

DOI:
10.3389/fnins.2019.00205 – link to the publication
Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species.

Authors:
Topf U., Suppanz I., Wrobel L., Böser A., Samluk L., Sakowska P., Knapp B., Chacinska A., Warscheid B.

Academic press:
Nature Communications (year: 2018, volume: 9(1), pages: 324), Publisher: Nature Publishing Group

Status:
Published

DOI:
10.1038/s41467-017-02694-8 – link to the publication

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