Projects search

A novel route for preparing 5′ cap mimics and capped RNAs: phosphate-modified cap analogues obtained via click chemistry

Authors:

Sylwia Walczak, Anna Nowicka, Dorota Kubacka, Kaja Fac, Przemyslaw Wanat, Seweryn Mroczek, Joanna Kowalska, Jacek Jemielity

Academic press:

Chemical Science (year: 2017, volume: 8, pages: 260-267), Publisher: The Royal Society of Chemistry

Status:

Published

DOI:

10.1039/c6sc02437h – link to the publication

Structural basis of mRNA-cap recognition by Dcp1–Dcp2

Authors:

Jeffrey S. Mugridge, Marcin Ziemniak, Jacek Jemielity, John D. Gross

Academic press:

Nature Structural & Molecular Biology (year: 2016, volume: 23, pages: 987-994), Publisher: NATURE PUBLISHING GROUP

Status:

Published

DOI:

10.1038/nsmb.3301 – link to the publication

Fluorescent HTS assay for phosphohydrolases based on nucleoside 5ʹ-fluorophosphates: application in screening for inhibitors of mRNA Decapping Scavenger and PDE-I

Authors:

Marek R. Baranowski, Anna Nowicka, Jacek Jemielity, Joanna Kowalska

Academic press:

Organic & Biomolecular Chemistry (year: 2016, volume: 14, pages: 4595-4604), Publisher: The Royal Society of Chemistry

Status:

Published

DOI:

10.1039/c6ob00492j – link to the publication

Clickable trimethylguanosine cap analogs modified within the triphosphate bridge: synthesis, conjugation to RNA and susceptibility to degradation

Authors:

Blazej A. Wojtczak, Marcin Warminski, Joanna Kowalska, Malgorzata Honcharenko, C. I. Edvard Smith, Roger Stromberg, Edward Darzynkiewicz, Jacek Jemielity

Academic press:

RSC Advances (year: 2016, volume: 6, pages: 8317-8328), Publisher: ROYAL SOC CHEMISTRY

Status:

Published

DOI:

10.1039/c5ra25684d – link to the publication

Ethynyl, 2-Propynyl, and 3-Butynyl C-Phosphonate Analogues of Nucleoside Di- and Triphosphates: Synthesis and Reactivity in CuAAC

Authors:

Przemyslaw Wanat, Sylwia Walczak, Blazej A. Wojtczak, Monika Nowakowska, Jacek Jemielity, Joanna Kowalska

Academic press:

Organic Letters (year: 2015, volume: 17, pages: 3062-3065), Publisher: AMER CHEMICAL SOC

Status:

Published

DOI:

10.1021/acs.orglett.5b01346 – link to the publication

Synthesis of Fluorophosphate Nucleotide Analogues and Their Characterization as Tools for 19F NMR Studies

Authors:

Marek R. Baranowski, Anna Nowicka, Anna M. Rydzik, Marcin Warmiński, Renata Kasprzyk, Błażej A. Wojtczak, Jacek Wójcik, Timothy D. W. Claridge, Joanna Kowalska, Jacek Jemielity

Academic press:

The Journal of Organic Chemistry (year: 2015, volume: 80, pages: 3982-3997), Publisher: AMER CHEMICAL SOC

Status:

Published

DOI:

10.1021/acs,joc.5b00337 – link to the publication

Synthetic m3G-CAP attachment necessitates a minimum trinucleotide constituent to be recognised as a nuclear import signal

Authors:

Malgorzata Honcharenko, Burcu Bestas, Martina Jezowska, Blazej A Wojtczak, Pedro Moreno, Joanna Romanowska, Susanna M Bächle, Edward Darzynkiewicz, Jacek Jemielity, C. I. Edvard Smith, Roger Stromberg

Academic press:

RSC Advances (year: 2016, volume: 6, pages: 51367-51373), Publisher: The Royal Society of Chemistry

Status:

Published

DOI:

10.1039/C6RA09568B – link to the publication

Cap analogs modified with 1,2-dithiodiphosphate moiety protect mRNA from decapping and enhance its translational potential

Authors:

Malwina Strenkowska, Renata Grzela, Maciej Majewski, Katarzyna Wnek, Joanna Kowalska, Maciej Lukaszewicz, Joanna Zuberek, Edward Darzynkiewicz, Andreas N Kuhn, Ugur Sahin, Jacek Jemielity

Academic press:

Nucleic Acids Research (year: 2016, volume: 44, pages: 9578-9590), Publisher: Oxford University Press

Status:

Published

DOI:

10.1093/nar/gkw896 – link to the publication

Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes

Authors:

Joanna Kowalska, Anna Wypijewska del Nogal, Zbigniew M. Darzynkiewicz, Janina Buck, Corina Nicola, Andreas N. Kuhn, Maciej Lukaszewicz, Joanna Zuberek, Malwina Strenkowska, Marcin Ziemniak, Maciej Maciejczyk, Elzbieta Bojarska, Robert E. Rhoads, Edward Darzynkiewicz, Ugur Sahin and Jacek Jemielity

Academic press:

Nucleic Acids Research (year: 2014, volume: 42, pages: 10245–10264), Publisher: Oxford University Press

Status:

Published

DOI:

10.1093/nar/gku757 – link to the publication

Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation

Authors:

Katharina Essig, Nina Kronbeck, Joao C. Guimaraes, Claudia Lohs, Andreas Schlundt, Anne Hoffmann, Gesine Behrens, Sven Brenner, Joanna Kowalska, Cristina Lopez-Rodriguez, Jacek Jemielity, Helmut Holtmann, Kristin Reiche, Jörg Hackermüller, Michael Sattler, Mihaela Zavolan , Vigo Heissmeyer

Academic press:

Nature Communications (year: 2018, volume: 9, pages: 3810), Publisher: NATURE PUBLISHING GROUP, MACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLAND

Status:

Published

DOI:

10.1038/s41467-018-06184-3 – link to the publication

mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation

Authors:

Anna M. Rydzik, Marcin Warminski, Pawel J. Sikorski, Marek R. Baranowski, Sylwia Walczak, Joanna Kowalska, Joanna Zuberek, Maciej Lukaszewicz, Elzbieta Nowak, Timothy D. W. Claridge, Edward Darzynkiewicz, Marcin Nowotny, Jacek Jemielity

Academic press:

Nucleic Acids Research (year: 2017, volume: 45, pages: 8661-8675), Publisher: Oxford University Press

Status:

Published

DOI:

10.1093/nar/gkx569 – link to the publication

Cap analogs containing 6-thioguanosine – reagents for the synthesis of mRNAs selectively photo-crosslinkable with cap-binding biomolecules

Authors:

Monika Nowakowska, Joanna Kowalska, Franck Martin, Arnaud d'Orchymont, Joanna Zuberek, Maciej Lukaszewicz, Edward Darzynkiewicza and Jacek Jemielity

Academic press:

Org. Biomol. Chem. (year: 2014, volume: 12, pages: 4841–4847), Publisher: The Royal Society of Chemistry

Status:

Published

DOI:

10.1039/c4ob00059e – link to the publication

Potential therapeutic applications of RNA cap analogs

Authors:

Marcin Ziemniak, Malwina Strenkowska, Joanna Kowalska, Jacek Jemielity

Academic press:

Future Medicinal Chemistry (year: 2013, volume: 5, pages: 1141-1172), Publisher: FUTURE SCI LTD, UNITED HOUSE, 2 ALBERT PL, LONDON, N3 1QB, ENGLAND

Status:

Published

DOI:

10.4155/fmc.13.96) – link to the publication

Analysis of Decapping Scavenger (DcpS)-cap complex using modified cap analogs reveals molecular determinants for efficient cap binding

Authors:

Anna Wypijewska del Nogal, Marius D. Surleac, Joanna Kowalska, Maciej Lukaszewicz, Jacek Jemielity, Martin Bisaillon, Edward Darzynkiewicz, Adina L. Milac, Elzbieta Bojarska

Academic press:

FEBS Journal (year: 2013, volume: 280, pages: 6508-6527), Publisher: WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA

Status:

Published

DOI:

10.1111/febs.12553 – link to the publication

Five eIF4E isoforms from Arabidopsis thaliana are characterized by distinct features of cap analogs binding

Authors:

Anna Kropiwnicka, Krzysztof Kuchta, Maciej Lukaszewicz, Joanna Kowalska, Jacek Jemielity, Krzysztof Ginalski, Edward Darzynkiewicz, Joanna Zuberek

Academic press:

Biochemical and Biophysical Research Communications (year: 2015, volume: 456, pages: 47-52), Publisher: Elsevier Inc.

Status:

Published

DOI:

10.1016/j.bbrc.2014.11.032 – link to the publication

The synthesis of isopropylidene mRNA cap analogs modified with phosphorothioate moiety and their evaluation as promoters of mRNA translation

Authors:

Marcin Warminski, Joanna Kowalska, Janina Buck, Joanna Zuberek, Maciej Lukaszewicz, Corina Nicola, Andreas N. Kuhn , Ugur Sahin, Edward Darzynkiewicz, Jacek Jemielity

Academic press:

Bioorganic & Medicinal Chemistry Letters (year: 2013, volume: 23, pages: 3753-3758), Publisher: PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND

Status:

Published

DOI:

10.1016/j.bmcl.2013.05.001 – link to the publication

Synthesis and evaluation of fluorescent cap analogues for mRNA labelling

Authors:

Marcin Ziemniak, Mariusz Szabelski, Maciej Lukaszewicz, Anna Nowicka, Edward Darzynkiewicz, Zbigniew Wieczorek, Robert E. Rhoads, Jacek Jemielity

Academic press:

RSC Advances (year: 2013, volume: 3, pages: 20943-20958), Publisher: ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND

Status:

Published

DOI:

10.1039/c3ra42769b – link to the publication

Synthetic Capped mRNAs for Cap-Specific Photo-Cross-Linking Experiments

Authors:

Joanna Kowalska, Franck Martin, Jacek Jemielity

Book:

Synthetic mRNA: Production, Introduction Into Cells, and Physiological Consequences (year: 2016, volume: 1428, pages: 31-43), Publisher: Springer Science+Business Media

Status:

Published