Projects funded by the NCN

Structural engineering of cell-penetrating peptides into biostable antibacterials to combat drug-resistant pathogens

Call: OPUS 29 , Panel: NZ1

Principal investigator: prof. Joanna Dominika Trylska

Uniwersytet Warszawski

The first antibody-drug conjugates for Alzheimer's disease therapy

Call: SONATA BIS 14 , Panel: NZ5

Principal investigator: dr hab. Marcin Łukasz Poręba

Politechnika Wrocławska

Computational alchemy and experimental validation: a hybrid approach for designing new antimicrobial peptides

Call: PRELUDIUM 22 , Panel: NZ1

Principal investigator: Piotr Maciej Chyży

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Conjugates of peptide nucleic acids with aminoglycosides and fluoroquinolones as a novel strategy to target multi-drug r...

Call: PRELUDIUM 22 , Panel: ST5

Principal investigator: Izabela Siekierska

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Research on the preparation of new, hydrogel nanosystems for targeted therapy of colorectal cancer

Call: SONATA 18 , Panel: NZ7

Principal investigator: dr Urszula Helena Piotrowska

Warszawski Uniwersytet Medyczny

Anticancer drug candidates from Nostoc edaphicum CCNP1411 and Pseudanabaena galeata CCNP1313 (CYANOCRAB)

Call: OPUS 23 , Panel: NZ9

Principal investigator: prof. Hanna Jurata Mazur-Marzec

Uniwersytet Gdański, Wydział Chemii

Bionanoparticles with a molecular targeting device as a weapon for breast cancer

Call: OPUS 23 , Panel: NZ7

Principal investigator: prof. Sylwia Anna Rodziewicz-Motowidło

Uniwersytet Gdański, Wydział Chemii

Inhibiting the Mitochondrial Intermembrane Space Assembly pathway as a newapproach to prevent metabolic reprogramming of...

Call: OPUS 22 , Panel: NZ5

Principal investigator: dr hab. Carlo Vascotto

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

Development of tools for the rational design of peptide therapeutics

Call: OPUS 20 , Panel: NZ2

Principal investigator: dr hab. Sebastian Kmiecik

Uniwersytet Warszawski, Centrum Nauk Biologiczno-Chemicznych

Dissecting cancer activome to develop new generation of antibody-drug conjugates

Call: OPUS 20 (LAP) , Panel: NZ5

Principal investigator: dr hab. Marcin Łukasz Poręba

Politechnika Wrocławska

Insulin – metallacarborane conjugates: A new strategy to enhance the biological efficacy of peptide drugs

Call: PRELUDIUM BIS 1 , Panel: NZ7

Principal investigator: dr hab. Tomasz Marek Goszczyński

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Lipophilic Prodrug Charge Masking (LPCM) as a novel strategy to enhance oral bioavailability of charged active peptides....

Call: SONATA 15 , Panel: NZ7

Principal investigator: dr Agata Elżbieta Gitlin-Domagalska

Uniwersytet Gdański, Wydział Chemii

Mesoporous and self-assembling molecular transporters as carriers of drugs and others low-molecular chemical species.

Call: OPUS 16 , Panel: ST4

Principal investigator: prof. Marek Józef Potrzebowski

Centrum Badań Molekularnych i Makromolekularnych PAN

Interaction of membrane-active peptides with model cell membrane and their role in a drug delivery system. Electrochemic...

Call: OPUS 12 , Panel: ST4

Principal investigator: dr Piotr Rafał Pięta

Instytut Chemii Fizycznej Polskiej Akademii Nauk

Design and chemical synthesis of peptide-based conjugates with antimicrobial activity - a promising approach to improve ...

Call: OPUS 11 , Panel: ST5

Principal investigator: prof. Krzysztof Rolka

Uniwersytet Gdański, Wydział Chemii

Altered interaction between NMDA receptor subunits and their scaffolding proteins as a critical step to control drug see...

Call: OPUS 9 , Panel: NZ7

Principal investigator: prof. Małgorzata Maria Filip

Instytut Farmakologii PAN

Abeta 4-x peptides as copper binding molecules resistant to chelating drugs, promoting the formation of amyloid oligomer...

Call: OPUS 8 , Panel: ST5

Principal investigator: prof. Wojciech Bal

Instytut Biochemii i Biofizyki PAN

Engineering disulfide bridges in human beta-defensin 3 for novel antibacterial and antifungal activities

Call: SONATA 8 , Panel: ST5

Principal investigator: dr Aleksandra Walewska

Uniwersytet Gdański, Wydział Chemii

Novel peptide inhibitors of dipeptidyl peptidase IV (DPP IV) as novel approach for diabetes type 2 and inflammatory bowe...

Call: PRELUDIUM 6 , Panel: NZ7

Principal investigator: Maciej Stanisław Sałaga

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Synthesis, physico-chemical and biological studies on macromolecular carriers of antimicrobial peptides

Call: PRELUDIUM 6 , Panel: NZ7

Principal investigator: Urszula Helena Piotrowska

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

A novel strategy for construction of antifungal pro-drugs based on the cell-penetrating peptides

Call: OPUS 3 , Panel: ST5

Principal investigator: prof. Sławomir Piotr Milewski

Politechnika Gdańska, Wydział Chemiczny