Zmiana języka

Projects search

Interaction of membrane-active peptides with model cell membrane and their role in a drug delivery system. Electrochemical, PM IRRAS as well as STM and AFM studies.

2016/23/B/ST4/02791

Keywords

Descriptors

  • ST4_13: Chemia fizyczna układów biologicznych
  • ST4_3: Metody spektroskopowe i spektrometryczne
  • ST5_4: Cienkie warstwy

Panel

ST4 – Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution

Instytut Chemii Fizycznej Polskiej Akademii Nauk

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Piotr Rafał Pięta

Number of co-investigators in the project: 3

Call

OPUS 12 – announced on 2016-09-15

Amount awarded
1 108 450 PLN
Project start date
2017-08-09
Project end date
2021-02-08
Project duration
42 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Laptop z oprogramowaniem. Cost: 12 000 PLN
  2. Naczynko elektrochemiczne do pomiarów PM-IRRAS. Cost: 160 000 PLN
  3. Przystawka niskoprądowa.
  4. Spektrometr FT-IR z wyposażeniem do PM-IRRAS. Cost: 495 000 PLN
  5. UVO-cleaner. Cost: 30 000 PLN

Information in the final report

Publication in academic press/journals (7)

  1. Inhibition of Amyloid β-Induced Lipid Membrane Permeation and Amyloid β Aggregation by K162

    Authors:
    D. Mrdenovic, P. Zarzycki, M. Majewska, I. S. Pieta, R. Nowakowski, W. Kutner, J. Lipkowski, P. Pieta
    Academic press:
    ACS Chem. Neurosci. (year: 2021, volume: 12, pages: 531-541), Publisher: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acschemneuro.0c00754 – link to the publication

  2. Toxicity of selected airborne nitrophenols on eukaryotic cell membrane models

    Authors:
    M. Majewska, F. Khan, I. S. Pieta, A. Wróblewska, R. Szmigielski, P. Pieta
    Academic press:
    Chemosphere (year: 2021, volume: 266, pages: 128996), Publisher: Elsever
    Status:
    Published
    DOI:
    10.1016/j.chemosphere.2020.128996 – link to the publication

  3. Alzheimer's disease-related amyloid beta peptide causes structural disordering of lipids and changes the electric properties of a floating bilayer lipid membrane

    Authors:
    D. Mrdenovic, Z. Su, W. Kutner, J. Lipkowski, P. Pieta
    Academic press:
    Nanoscale Advances (year: 2020, volume: 2, pages: 3467-3480), Publisher: The Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D0NA00292E – link to the publication

  4. Nanomechanical characterization of single phospholipid bilayer in ripple phase with PF-QNM AFM

    Authors:
    M. Majewska, D. Mrdenovic, I. S. Pieta, R. Nowakowski, P. Pieta
    Academic press:
    Biochim. et Biophys. Acta – Biomembranes (year: 2020, volume: 1862, pages: 183347), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbamem.2020.183347 – link to the publication

  5. Size-Dependent Interaction of Amyloid β Oligomers with Brain Total Lipid Extract Bilayer—Fibrillation Versus Membrane Destruction

    Authors:
    Dusan Mrdenovic, Marta Majewska, Izabela S. Pieta, Piotr Bernatowicz, Robert Nowakowski, Wlodzimierz Kutner, Jacek Lipkowski, Piotr Pieta
    Academic press:
    Langmuir (year: 2019, volume: 35, pages: 11940-11949), Publisher: ACS Publication
    Status:
    Published
    DOI:
    10.1021/acs.langmuir.9b01645 – link to the publication

  6. Interaction of LL-37 human cathelicidin peptide with model microbial-like lipid membrane

    Authors:
    Marta Majewska, Vlad Zamlynny, Izabela S. Pieta, Robert Nowakowski, Piotr Pieta
    Academic press:
    Bioelectrochemistry (year: 2021, volume: 141, pages: 107842), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioelechem.2021.107842 – link to the publication

  7. Amyloid β interaction with model cell membranes – What are the toxicity-defining properties of amyloid β?

    Authors:
    D. Mrdenovic, I. S. Pieta, R. Nowakowski, W. Kutner, J. Lipkowski, P. Pieta
    Academic press:
    Internationa Journal of Biological Macromolecules (year: 2022, volume: 200, pages: 520-531), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2022.01.117 – link to the publication

Book publications / chapters in book publications (1)

  1. Analysis of early-stage toxic properties of amyloid β oligomers by atomic force microscopy

    Authors:
    D. Mrdenovic, J. Lipkowski, P. Pieta
    Book:
    Membrane Lipids in Methods in Molecular Biology (year: 2022, volume: 2402, pages: 227-241), Publisher: Humana, New York, NY
    Status:
    Published

« New search

Graphic design and implementation: Jakub Piotrowski