Projects funded by the NCN
Computational alchemy and experimental validation: a hybrid approach for designing new antimicrobial peptides
2023/49/N/NZ1/00989
Keywords:
multi-drug resistance antimicrobial peptides computational alchemy minimum inhibitory concentration hydrocarbon stapling non-standard amino acids molecular dynamics with enhanced conformational sampling
Descriptors:
- NZ1_03:
- NZ2_10:
- ST5_12:
Panel:
NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution :
Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego
woj. mazowieckie
Principal investigator (from the host institution):
Number of co-investigators in the project: 2
Call: PRELUDIUM 22 - announced on 2023-03-16
Amount awarded: 139 997 PLN
Project start date (Y-m-d): 2024-01-16
Project end date (Y-m-d): 2027-01-15
Project duration:: 36 months (the same as in the proposal)
Project status: Pending project
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (1)
- Design, synthesis and evaluation of lysine- and leucine-rich hydrocarbon-stapled peptides as antibacterial agentsAuthors:Małgorzata Lobka, Izabela Siekierska, Piotr Chyży, Michał Burmistrz, Julia Macyszyn, Renata Grzela, Monika Wojciechowska, Joanna TrylskaAcademic press:European Journal of Medicinal Chemistry (rok: 2025, tom: 290, strony: 117445), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.ejmech.2025.117445 - link to the publication