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Abeta 4-x peptides as copper binding molecules resistant to chelating drugs, promoting the formation of amyloid oligomers.

2014/15/B/ST5/05229

Keywords:

Abeta peptide Cu(II) coordination aggregation

Descriptors:

  • NZ1_3: Biophysics
  • ST5_14: Other related subjects
  • ST5_16:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Instytut Biochemii i Biofizyki PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Wojciech Bal 

Number of co-investigators in the project: 4

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 621 400 PLN

Project start date (Y-m-d): 2015-07-21

Project end date (Y-m-d): 2018-07-20

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (6)
  1. A Functional Role for Ab in Metal Homeostasis? N-Truncation and High-Affinity Copper Binding
    Authors:
    M. Mital, N. E. Wezynfeld, T. Frączyk, M. Z. Wiloch, U. E. Wawrzyniak, A. Bonna, C. Tumpach, C. L. Haigh, K. J. Barnham, W. Bal, S. C. Drew
    Academic press:
    Angewandte Chemie International Edition (rok: 2015, tom: 54, strony: 10460-10464), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/anie.201502644 - link to the publication
  2. Cysteine and Glutathione trigger the Cu-Zn swap between Cu(II)-Amyloid-β4-16 peptide and Zn7-Metallothionein-3,
    Authors:
    A. Santoro, N. Wezynfeld, M. Vasak, W. Bal, P. Faller
    Academic press:
    Chemical Communications (rok: 2017, tom: 53, strony: 11634-11637), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C7CC06802F - link to the publication
  3. Interplay between copper, neprilysin and N-truncation of β-amyloid
    Authors:
    M. Mital, W. Bal, T. Frączyk, S. C. Drew
    Academic press:
    Inorganic Chemistry (rok: 2018, tom: 57, strony: 6193-6197), Wydawca: Americn Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.8b00391 - link to the publication
  4. Copper Exchange and Redox Activity of a Prototypical 8-Hydroxyquinoline: Implications for Therapeutic Chelation
    Authors:
    M. Mital, I. A. Zawisza, M. Z. Wiloch, U. E. Wawrzyniak, V. Kenche, W. Wróblewski, W. Bal, S. C. Drew
    Academic press:
    Inorganic Chemistry (rok: 2016, tom: 55, strony: 7317-7319), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.6b00832 - link to the publication
  5. Tuning the redox properties of copper(II) complexes with amyloid-β peptides
    Authors:
    M. Z. Wiloch, U. E. Wawrzyniak, I. Ufnalska, A. Bonna, W. Bal, S. C. Drew, W. Wróblewski
    Academic press:
    J. Electrochem. Soc. (rok: 2016, tom: 163, strony: G196-G199), Wydawca: The Electrochemical Society
    Status:
    Published
    DOI:
    10.1149/2.0641613jes - link to the publication
  6. Resistance of Cu(Aβ4-16) to copper capture by metallothionein 3 supports a function of Aβ4-42 peptide as synaptic CuII scavenger
    Authors:
    N. E. Wezynfeld, E. Stefaniak, K. Stachucy, A. Drozd, D. Płonka, S. C. Drew, A. Krężel, W. Bal
    Academic press:
    Angewandte Chemie International Edition (rok: 2016, tom: 55, strony: 8235–8238), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/anie.201511968 - link to the publication

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