Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Engineering disulfide bridges in human beta-defensin 3 for novel antibacterial and antifungal activities

2014/15/D/ST5/03941

Keywords:

human beta-defensins HBD-3 peptide synthesis disulfide bond engineering antimicrobial activity multi-drug resistance diselenide bridge serum stability PEGylation dicarba bridge

Descriptors:

  • ST5_16:
  • ST5_23:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Gdański, Wydział Chemii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Aleksandra Walewska 

Number of co-investigators in the project: 4

Call: SONATA 8 - announced on 2014-09-15

Amount awarded: 448 170 PLN

Project start date (Y-m-d): 2015-07-20

Project end date (Y-m-d): 2020-07-19

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Detektor dwuwiązkowy UV-Vis do systemu HPLC (41 000 PLN)
  2. Komputer stacjonarny (9 124 PLN)
  3. Waga analityczna, dokładność 0,01/0,1 mg, średnica szalki 90 mm.
  4. Wytrząsarka laboratoryjna typu SHAKER.
  5. Wirówka mikrolitrowa z rotorem do probówek o pojemności 1,5/2 ml (9 500 PLN)

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (4)
  1. Improving Fmoc Solid Phase Synthesis of Human Beta Defensin 3
    Authors:
    Aleksandra Walewska, Paulina Kosikowska-Adamus, Marta Tomczykowska, Bartosz Jaroszewski, Adam Prahl, Grzegorz Bulaj
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 12562), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms232012562 - link to the publication
  1. Disulfide-deficient analogues beta-defensin 3
    Authors:
    Aleksandra Walewska, Dagmara Ostrowska, Piotr Szweda, Adam Prahl
    Conference:
    23 Polskie Sympozjum Peptydowe (rok: 2015, ), Wydawca: Instytut Chemii Organicznej, Politechnika Łódzka
    Data:
    konferencja 30.08-03.09
    Status:
    Published
  2. Serum stability studies of disulfide-deficient human beta-defensin 3 analogues using UFLC and MS
    Authors:
    Aleksandra Walewska, Joanna Grabowska, Paulina Zyra, Adam Prahl
    Conference:
    Flow analysis & capillary electrophoresis (rok: 2016, ), Wydawca: Department of Analytical Chemistry, Faculty of Chemistry, Jagiellonian University in Kraków
    Data:
    konferencja 14.09-16.09
    Status:
    Published
  3. Simplified oxidative folding of disulfide-deficient selenopeptide analogues of HBD-3
    Authors:
    Aleksandra Walewska, Paulina Kosikowska-Adamus, Adam Prahl
    Conference:
    International Meeting of Animicrobial Peptides (rok: 2019, ), Wydawca: University of Utrecht
    Data:
    konferencja 28-30.08
    Status:
    Published
    DOI:
    link to the publication
  4. Chemical synthesis, antimicrobial activity and serum stability studies of disulfide-depleted human beta-defensing 3 analogues
    Authors:
    Walewska Aleksandra, Kosikowska-Adamus Paulina, Prahl Adam
    Conference:
    24th Polish Peptide Symposim (rok: 2017, ), Wydawca: Department of Biomedical Chemistry, Faculty of Chemistry, University of Gdańsk
    Data:
    konferencja 03.09-07.09
    Status:
    Published

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