Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Lipophilic Prodrug Charge Masking (LPCM) as a novel strategy to enhance oral bioavailability of charged active peptides. Optimization and generalization of the method.

2019/35/D/NZ7/00174

Keywords:

peptides biovailability oral delivery prodrugs peptide drugs permebaility,

Descriptors:

  • NZ7_014:
  • ST5_009:
  • ST4_009:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Gdański, Wydział Chemii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Agata Elżbieta Gitlin-Domagalska 

Number of co-investigators in the project: 6

Call: SONATA 15 - announced on 2019-09-16

Amount awarded: 1 128 600 PLN

Project start date (Y-m-d): 2020-06-25

Project end date (Y-m-d): 2025-06-24

Project duration:: 60 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  1. Vasopressin and its analogues: from natural hormones to multitasking peptides
    Authors:
    Glavas M., Gitlin-Domagalska A., Dębowski D., Ptaszyńska N., Łęgowska A., Rolka K.,
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 3068), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23063068 - link to the publication
  2. Cyclic peptidic furin inhibitors developed by combinatorial chemistry
    Authors:
    Gitlin-Domagalska A., Dębowski D.*, Maciejewska A., Samsonov S., Maszota-Zieleniak M., Ptaszyńska N., Łęgowska A., Rolka K.,
    Academic press:
    ACS Medicinal Chemistry Letters (rok: 2023, tom: 14, strony: 458-465), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acsmedchemlett.3c00008 - link to the publication
  3. Vasopressin and its analogues: from natural hormones to multitasking peptides
    Authors:
    Glavas M., Gitlin-Domagalska A., Dębowski D., Ptaszyńska N., Łęgowska A., Rolka K.,
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 3068), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23063068 - link to the publication
  4. Synthesis of Novel Arginine Building Blocks with Increased Lipophilicity Compatible with Solid-Phase Peptide Synthesis
    Authors:
    22. Glavas M., Gitlin-Domagalska A.*, Prtaszyńska N., Starego D., Freza S., Dębowski D., Hlebik-Maciejwska A., łęgowska A., Gilon C., Rolka K.,
    Academic press:
    Molecules (rok: 2023, tom: 28, strony: 7780), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules28237780 - link to the publication
  5. Synthesis of Novel Arginine Building Blocks with Increased Lipophilicity Compatible with Solid-Phase Peptide Synthesis
    Authors:
    22. Glavas M., Gitlin-Domagalska A.*, Prtaszyńska N., Starego D., Freza S., Dębowski D., Hlebik-Maciejwska A., łęgowska A., Gilon C., Rolka K.,
    Academic press:
    Molecules (rok: 2023, tom: 28, strony: 7780), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules28237780 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy