Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Mesoporous and self-assembling molecular transporters as carriers of drugs and others low-molecular chemical species.

2018/31/B/ST4/01973

Keywords:

molecular carriers mesoporous nanoparticles peptide nanotubes and nanowires drug delivery systems NMR spectroscopy in the solid state

Descriptors:

  • ST4_3:
  • ST5_22:
  • ST4_4:

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Marek Józef Potrzebowski 

Number of co-investigators in the project: 8

Call: OPUS 16 - announced on 2018-09-14

Amount awarded: 1 812 200 PLN

Project start date (Y-m-d): 2019-06-24

Project end date (Y-m-d): 2024-06-23

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (12)
  • Book publications / chapters in book publications (1)
  1. Influence of heterochirality on the structure, dynamics, biological properties of cyclic(PFPF) tetrapeptides obtained by solvent-free ball mill mechanosynthesis
    Authors:
    Irena Bak-Sypien, Tomasz Pawlak, Piotr Paluch, Aneta Wroblewska, Rafał Dolot, Aleksandra Pawlowicz, Małgorzata Szczesio, Ewelina Wielgus, Slawomir Kazmierski, Marcin Górecki, Roza Pawlowska, Arkadiusz Chworos, Marek J. Potrzebowski
    Academic press:
    Scientific Reports (rok: 2024, tom: 14, strony: 12825), Wydawca: Nature Portfolio
    Status:
    Published
    DOI:
    10.1038/s41598-024-63552-4 - link to the publication
  2. Unexpected Factors Affecting the Kinetics of Guest Molecule Release from Investigation of Binary Chemical Systems Trapped in a Single Void of Mesoporous Silica Particles
    Authors:
    Katarzyna Trzeciak, Ewelina Wielgus, Sławomir Kaźmierski, Mehrnaz Khalaji, Marta K. Dudek and Marek J. Potrzebowski
    Academic press:
    ChemPhysChem (rok: 2023, tom: 24, strony: e202200884), Wydawca: WILEY-VCH GmbH
    Status:
    Published
    DOI:
    10.1002/cphc.202200884 - link to the publication
  3. Mapping of Guest Localization in Mesoporous Silica Particle by Solid-State NMR and Ab Initio Modeling: New Insights into Benzoic Acid and p-Fluorobenzoic Acid Embedded in MCM-41 via Ball Milling.
    Authors:
    K. Trzeciak, S. Kaźmierski, K. Drużbicki, M. J. Potrzebowski
    Academic press:
    Journal of Physical Chemistry C (rok: 2021, tom: 125, strony: 10096–10109), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.jpcc.1c01675 - link to the publication
  4. Crystal memory" Affects the Properties of Peptide Hydrogels – The Case of the Cyclic Tyr-Tyr dipeptide
    Authors:
    Agata Chotera-Ouda, Agata Jeziorna, Sławomir Kaźmierski, Rafał Dolot, Marta K. Dudek, Marek J. Potrzebowski
    Academic press:
    Chemistry - A European Journal (rok: 2022, tom: 28, strony: e202202005), Wydawca: WILEY-VCH GmbH
    Status:
    Published
    DOI:
    10.1002/chem.202202005 - link to the publication
  5. Influence of heterochirality on the structure, dynamics, biological properties of cyclic(PFPF) tetrapeptides obtained by solvent-free ball mill mechanosynthesis
    Authors:
    Irena Bak-Sypien, Tomasz Pawlak, Piotr Paluch, Aneta Wroblewska, Rafał Dolot, Aleksandra Pawlowicz, Małgorzata Szczesio, Ewelina Wielgus, Slawomir Kazmierski, Marcin Górecki, Roza Pawlowska, Arkadiusz Chworos, Marek J. Potrzebowski
    Academic press:
    Scientific Reports (rok: 2024, tom: 14, strony: 12825), Wydawca: Nature Portfolio
    Status:
    Published
    DOI:
    10.1038/s41598-024-63552-4 - link to the publication
  6. Amorphization of Ethenzamide and Ethenzamide Cocrystals—A Case Study of Single and Binary Systems Forming Low-Melting Eutectic Phases Loaded on/in Silica Gel
    Authors:
    Katarzyna Trzeciak, Ewelina Wielgus, Sławomir Kaźmierski, Tomasz Pawlak, Marek J. Potrzebowski
    Academic press:
    Pharmaceutics (rok: 2023, tom: 15, strony: 1234), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics15041234 - link to the publication
  7. Mesoporous Silica Particles as Drug Delivery Systems—The State of the Art in Loading Methods and the Recent Progress in Analytical Techniques for Monitoring These Processes.
    Authors:
    K. Trzeciak, A. Chotera-Ouda, I. I. Bak-Sypien, M. J. Potrzebowski
    Academic press:
    Pharmaceutics (rok: 2021, tom: 13, strony: 950), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics13070950 - link to the publication
  8. Mesoporous Silica Particles as Drug Delivery Systems—The State of the Art in Loading Methods and the Recent Progress in Analytical Techniques for Monitoring These Processes.
    Authors:
    K. Trzeciak, A. Chotera-Ouda, I. I. Bak-Sypien, M. J. Potrzebowski
    Academic press:
    Pharmaceutics (rok: 2021, tom: 13, strony: 950), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics13070950 - link to the publication
  9. Mapping of Guest Localization in Mesoporous Silica Particle by Solid-State NMR and Ab Initio Modeling: New Insights into Benzoic Acid and p-Fluorobenzoic Acid Embedded in MCM-41 via Ball Milling.
    Authors:
    K. Trzeciak, S. Kaźmierski, K. Drużbicki, M. J. Potrzebowski
    Academic press:
    Journal of Physical Chemistry C (rok: 2021, tom: 125, strony: 10096–10109), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.jpcc.1c01675 - link to the publication
  10. Crystal memory" Affects the Properties of Peptide Hydrogels – The Case of the Cyclic Tyr-Tyr dipeptide
    Authors:
    Agata Chotera-Ouda, Agata Jeziorna, Sławomir Kaźmierski, Rafał Dolot, Marta K. Dudek, Marek J. Potrzebowski
    Academic press:
    Chemistry - A European Journal (rok: 2022, tom: 28, strony: e202202005), Wydawca: WILEY-VCH GmbH
    Status:
    Published
    DOI:
    10.1002/chem.202202005 - link to the publication
  11. DiSupLo - New extremely easy and efficient method for loading of active pharmaceutical ingredients into the pores of MCM-41 mesoporous silica particles
    Authors:
    K. Trzeciak, S. Kaźmierski, E. Wielgus, M. J. Potrzebowski
    Academic press:
    Microporous and Mesoporous Materials (rok: 2020, tom: 308, strony: 110506), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.micromeso.2020.110506 - link to the publication
  12. Solvent-Free Mechanosynthesis of Oligopeptides by Coupling Peptide Segments of Different Lengths – Elucidating the Role of Cesium Carbonate in Ball Mill Processes
    Authors:
    Aneta Wróblewska, Irena I. Bak-Sypien, Piotr Paluch, Ewelina Wielgus, Justyna Zając, Agata Jeziorna, Sławomir Kaźmierski, Marek J. Potrzebowski
    Academic press:
    Chemistry - A European Journal (rok: 2024, tom: brak, strony: e202400177), Wydawca: Wiley-VCH GmbH
    Status:
    Published
    DOI:
    10.1002/chem.202400177 - link to the publication
  1. Fast and very fast MAS solid state NMR studies of pharmaceuticals
    Authors:
    Marta K. Dudek, Sławomir Kaźmierski, Marek J. Potrzebowski
    Book:
    Annual Reports on NMR Spectroscopy (rok: 2021, tom: 103, strony: 97-189), Wydawca: Elsevier
    Status:
    Published

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