Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Design and chemical synthesis of peptide-based conjugates with antimicrobial activity - a promising approach to improve pharmacological profiles of antibiotic drugs

2016/21/B/ST5/00101

Keywords:

peptides conjugates chemical synthesis antimicrobial activity

Descriptors:

  • ST5_11: Smart materials – self assembled materials, external stimuli-responsive materials
  • ST5_16:
  • ST5_23:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Gdański, Wydział Chemii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Krzysztof Rolka 

Number of co-investigators in the project: 7

Call: OPUS 11 - announced on 2016-03-15

Amount awarded: 1 172 260 PLN

Project start date (Y-m-d): 2017-01-18

Project end date (Y-m-d): 2020-07-17

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Gradientowy, semipreparatywny chromatograf cieczowy (HPLC) z detektorem UV/VIS (210 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (3)
  1. Antibiotic-Based Conjugates Containing Antimicrobial HLopt2 Peptide: Design, Synthesis, Antimicrobial and Cytotoxic Activities
    Authors:
    Ptaszyńska N., Gucwa K., Olkiewicz K., Łęgowska A., Okońska J., Ruczyński J., Gitlin-Domagalska A., Dębowski D., Milewski S., Rolka K.
    Academic press:
    ACS Chem. Biol. (rok: 2019, tom: 14, strony: 2233-2242), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acschembio.9b00538 - link to the publication
  2. Antimicrobial Activity of Chimera Peptides Composed of Human Neutrophil Peptide 1 (HNP-1) Truncated Analogues and Bovine Lactoferrampin
    Authors:
    Ptaszyńska N., Gucwa K., Łęgowska A., Dębowski D., Gitlin-Domagalska A., Lica J., Heldt M., Martynow D., Olszewski M., Milewski S., Ng T.B., Rolka K.,
    Academic press:
    Bioconjugate Chemistry (rok: 2018, tom: 29, strony: 3060-3071), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.bioconjchem.8b004400 - link to the publication
  3. Conjugates ofcCiprofloxacin and levofloxacin with cell-penetrating peptide exhibit antifungal activity and mammalian cytotoxicity
    Authors:
    Ptaszyńska N., Gucwa K., Olkiewicz K., Heldt M., Serocki M., Stupak A., Martynow D., Dębowski D., Gitlin-Domagalska A., Lica J, Łęgowska A., Milewski S., Rolka K.
    Academic press:
    Int. J. Mol. Sci. (rok: 2020, tom: 21, 4696, strony: 45316), Wydawca: MDPI AG
    Status:
    Published
    DOI:
    10.3390/ijms21134696 - link to the publication
  4. Peptide conjugates of lactoferricin analogues and antimicrobials-Design, chemical synthesis, and evaluation of antimicrobial activity and mammalian cytotoxicity
    Authors:
    Ptaszyńska N., Olkiewicz K., Okońska J., Gucwa K., Łęgowska A., Gitlin-Domagalska A., Dębowski D., Lica J., Heldt M., Milewski S., Ng T.B., Rolka K.
    Academic press:
    Peptides (rok: 2019, tom: 117, strony: 170079), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.peptides.2019.04.006 - link to the publication
  5. Truncation of Huia versabilis Bowman-Birk inhibitor increases its selectivity, matriptase-1 inhibitory activity and proteolytic stability
    Authors:
    Gitlin-Domagalska A., Dębowski D., Gucwa K., Starego D., Ptaszyńska N., Sieradzan A., Karczyńska A., A.Samsonow S., Mangold M., Gütschow M., Łęgowska A., Rolka K.,
    Academic press:
    Biochimie (rok: 2020, tom: 171-172, strony: 178-186), Wydawca: Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire
    Status:
    Published
    DOI:
    10.1016/j.biochi.2020.03.006 - link to the publication
  1. Antimicrobial activities of chimera peptides composed of human neutrophil peptide 1(HNP-1) truncated analogues and bovine lactoferrampin
    Authors:
    Ptaszyńska N., Gucwa K., Łęgowska A., Dębowski D., Gitlin-Domagalska A., Lica J., Heldt M., Martynow D., Olszewski M., Milewski S., Rolka K.
    Conference:
    35th European Peptide Symposium, Dublin City University, Irland (rok: 2018, ), Wydawca: European Peptide Society & PSP
    Data:
    konferencja 26th - 31st August 2018
    Status:
    Published
    DOI:
    link to the publication
  2. Design, chemical synthesis and evaluation of antimicrobial activity peptide conjugates of lactoferricin analogues and antibiotics
    Authors:
    Ptaszyńska N., Olkiewicz K., Okońska J., Łęgowska A., Gucwa K., Gitlin-Domagalska A., Dębowski D., Milewski S., Rolka K.
    Conference:
    35th European Peptide Symposium, Dublin City University, Irland (rok: 2018, ), Wydawca: European Peptide Society & PSP
    Data:
    konferencja 26th - 31st August 2018
    Status:
    Published
    DOI:
    link to the publication
  3. Peptide conjugates of transportan10 with antimicrobial and antifungal antibiotics
    Authors:
    Olkiewicz K., Łęgowska A., Ptaszyńska N., Gitlin- Domagalska A., Dębowski D., Okońska J., Martynow D., Serocki M., Milewski S., Rolka K.
    Conference:
    35th European Peptide Symposium, Dublin City University, Irland (rok: 2018, ), Wydawca: European Peptide Society & PSP
    Data:
    konferencja 26th - 31st August 2018
    Status:
    Published
    DOI:
    link to the publication

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