Projects funded by the NCN

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404 projects found matching your search criteria :

  1. Organometallic inhibitors of tubulin polymerisation. Synthesis, anticancer activities and tubulin affinities.

    Call: OPUS 3 , Panel: ST5

    Principal investigator: dr hab. Damian Plażuk

    Uniwersytet Łódzki, Wydział Chemii

  2. Stilbene and stilbazole derivatives as potential cyclooxygenase-2 (COX-2) inhibitors with probable antitumor and chemopr...

    Call: PRELUDIUM 1 , Panel: NZ4

    Principal investigator: Miłosz Regulski

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

  3. Modifications of aglycones of leucomycins via Michael addition and Huisgen dipolar cycloaddition as a new routes of synt...

    Call: SONATA BIS 1 , Panel: ST5

    Principal investigator: dr hab. Piotr Przybylski

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

  4. Identification of amino acid residues located in positions P7 and P8 of model inhibitor of proprotein convertases that d...

    Call: PRELUDIUM 3 , Panel: ST5

    Principal investigator: Izabela Małuch

    Uniwersytet Gdański, Wydział Chemii

  5. Synthesis of mononucleotide N2,N2,7-trimethylguanosine cap analogues as translation inhibitors in Ascaris suum

    Call: PRELUDIUM 3 , Panel: ST5

    Principal investigator: dr Karolina Piecyk

    Uniwersytet Warszawski, Wydział Chemii

  6. The influence of metabolic pathway inhibitors on the development and quality of bovine embryos produced in vitro.

    Call: OPUS 3 , Panel: NZ9

    Principal investigator: dr hab. Dorota Cieślak

    Uniwersytet Przyrodniczy w Poznaniu, Wydział Medycyny Weterynaryjnej i Nauk o Zwierzętach

  7. Pattern-Specific Inhibitors (PSI) - introduction and basic characteristics of a new class of inhibitors that block recog...

    Call: OPUS 3 , Panel: NZ6

    Principal investigator: dr Krzysztof Guzik

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  8. Role of ruthenium complexes interaction with NO in the context of angiogenesis inhibition.

    Call: PRELUDIUM 3 , Panel: ST5

    Principal investigator: dr Maria Oszajca

    Uniwersytet Jagielloński, Wydział Chemii

  9. Research into the understanding of a defense mechanism of wheat (Triticum aestivum) in response to feeding Oulema spp. -...

    Call: OPUS 2 , Panel: NZ9

    Principal investigator: dr hab. Aleksandra Obrępalska-Stęplowska

    Instytut Ochrony Roślin - Państwowy Instytut Badawczy

  10. Solution NMR investigations of human cystatin C - structure, dynamics and protein-ligand interactions.

    Call: PRELUDIUM 2 , Panel: ST4

    Principal investigator: Martyna Maszota-Zieleniak

    Uniwersytet Gdański, Wydział Chemii

  11. Conjugates of cap analogs with nanomaterials and biomolecules with potential applications in pharmacology or diagnostics

    Call: SONATA 1 , Panel: ST5

    Principal investigator: dr Joanna Kowalska

    Uniwersytet Warszawski, Wydział Fizyki

  12. Identifying of novel virus-encoded GW proteins that inhibit plant and animal RNAi-based defense systems.

    Call: PRELUDIUM 2 , Panel: NZ2

    Principal investigator: Andrzej Zieleziński

    Uniwersytet im. Adama Mickiewicza, Wydział Biologii

  13. Hydrogen exchange mass spectrometry (HXMS) for studying human serum amyloid A fibril formation.

    Call: PRELUDIUM 2 , Panel: NZ5

    Principal investigator: Marta Sosnowska

    Uniwersytet Gdański, Wydział Chemii

  14. Peptide splicing - the mechanism and its application for designing compounds with potential use in medicinal practice

    Call: OPUS 1 , Panel: ST5

    Principal investigator: prof. Krzysztof Rolka

    Uniwersytet Gdański, Wydział Chemii

  15. New approaches towards modulating selective and functional activities of antisense oligonucleotides

    Call: OPUS 2 , Panel: ST5

    Principal investigator: prof. Ryszard Kierzek

    Instytut Chemii Bioorganicznej PAN

  16. Novel urease inhibitors as means to control ureolytic microbial pathogens

    Call: OPUS 2 , Panel: NZ6

    Principal investigator: dr Agnieszka Grabowiecka

    POLITECHNIKA WROCŁAWSKA

  17. Design, synthesis and biological evaluation of Steroid Sulfatase Inhibitors based on organophosphorus compounds.

    Call: SONATA 2 , Panel: NZ7

    Principal investigator: dr Sebastian Demkowicz

    POLITECHNIKA GDAŃSKA

  18. Selective inhibition of Janus kinases for the treatment of autoimmune hepatitis: Translational PK/PD modelling from mole...

    Call: SONATA 19 , Panel: NZ7

    Principal investigator: dr Artur Świerczek

    Uniwersytet Jagielloński, Collegium Medicum

  19. Inhibitory Functional Networks in Addiction Development within Social Context - a Missing Piece of Puzzle

    Call: OPUS 26 , Panel: NZ4

    Principal investigator: dr Marzena Stefaniuk

    Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

  20. Flozins as potential inhibitors of aortic stenosis progression in patients with concomitant type 2 diabetes: impact on v...

    Call: OPUS 26 , Panel: NZ5

    Principal investigator: dr hab. Joanna Natorska

    Uniwersytet Jagielloński

  21. Modulation of the N-glycosylation as a tool to improve the CAR-T immunotherapy efficacy

    Call: OPUS 26 , Panel: NZ7

    Principal investigator: dr Agnieszka Graczyk-Jarzynka

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  22. Targeting adenylate kinase 4 (AK4) as a new paradigm in the treatment of non-small cell lung cancer: discovery and evalu...

    Call: OPUS 26 , Panel: NZ7

    Principal investigator: dr Magdalena Wujak

    Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy

  23. Design and synthesis of new rifampicin analogs as a source of effective bacterial RNA polymerase inhibitors

    Call: OPUS 2 , Panel: ST5

    Principal investigator: dr hab. Piotr Przybylski

    Uniwersytet im. Adama Mickiewicza, Wydział Chemii

  24. Novel aspects of the mechanisms of vascular toxicity of tyrosine kinase inhibitors: studies on their proinflammatory act...

    Call: OPUS 26 , Panel: NZ5

    Principal investigator: dr Tomasz Prajsnar

    Uniwersytet Jagielloński, Wydział Biologii

  25. Functional and structural analysis of anticancer drugs as protein biosynthesis inhibitors

    Call: OPUS 26 , Panel: NZ7

    Principal investigator: dr hab. Witold Szaflarski

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Medyczny

  26. Design and Development of Serine Hydroxymethyltransferase-2 (SHMT2) Inhibitors Blocking Tumor Growth

    Call: SONATA BIS 13 , Panel: NZ7

    Principal investigator: dr hab. Miłosz Ruszkowski

    Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

  27. Physiological significance and clinical implications of global and local inhibition of NRF2 transcriptional activity in ...

    Call: SONATA BIS 13 , Panel: NZ4

    Principal investigator: dr hab. Aleksandra Piechota-Polańczyk

    Uniwersytet Medyczny w Łodzi, Wydział Lekarski

  28. Molecular mechanisms of DNA damage triggered by PIM kinases inhibition and its consequences for activation of innate imm...

    Call: OPUS 25 , Panel: NZ5

    Principal investigator: prof. Przemysław Juszczyński

    Instytut Hematologii i Transfuzjologii

  29. Theoretical prediction, chemical synthesis and biological analysis of a novel class of HSPA5 inhibitors

    Call: OPUS 25 , Panel: ST4

    Principal investigator: prof. Arkadiusz Chworoś

    Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

  30. Compounds modulating function of telomeric proteins TRF1 and TRF2

    Call: OPUS 25 , Panel: NZ7

    Principal investigator: prof. Maciej Bagiński

    Politechnika Gdańska, Wydział Chemiczny

  31. Development of dual immuno-oligo- biosensors for monitoring and controlling of the metastatic colorectal cancer and inve...

    Call: OPUS 25 , Panel: ST4

    Principal investigator: dr hab. Magdalena Stobiecka

    Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Instytut Biologii

  32. Investigating the mechanisms of CD20 downregulation triggered by tyrosine kinase inhibitors in Philadelphia chromosome-p...

    Call: PRELUDIUM 22 , Panel: NZ5

    Principal investigator: Krzysztof Domka

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

  33. Understanding the contribution of immunoproteasome activation to the neuropathic pain development.

    Call: OPUS 25 , Panel: NZ7

    Principal investigator: dr Natalia Małek-Chudzik

    Politechnika Wrocławska

  34. Synthesis and biological activity evaluation of new hybrid derivatives of tacrine and melatonin as potential cholinester...

    Call: OPUS 2 , Panel: ST5

    Principal investigator: dr Anna Zawadzka

    Uniwersytet Warszawski, Wydział Chemii

  35. Search for novel IKK-β inhibitors in the context of diseases with neuroinflammatory origin – structure-based drug design...

    Call: PRELUDIUM 22 , Panel: NZ7

    Principal investigator: Emilia Sługocka

    Uniwersytet Jagielloński, Collegium Medicum

  36. Targeting Energy Metabolism for Precision Cancer Therapy: Novel Inhibitors of LDH-A and PDK1 as Potential Strategies to ...

    Call: PRELUDIUM 22 , Panel: NZ7

    Principal investigator: Marika Frańczak

    Gdański Uniwersytet Medyczny, Wydział Lekarski

  37. The design and development of the peptide inhibitors library targeting Zn(II)-binding site of matrix metalloproteinases ...

    Call: PRELUDIUM 22 , Panel: ST5

    Principal investigator: Paulina Potok

    Uniwersytet Wrocławski, Wydział Chemii

  38. Endothelial bioenergetics as a novel target for vascular protection – unveiling the mitochondrial mechanisms of lipid-lo...

    Call: PRELUDIUM 22 , Panel: NZ5

    Principal investigator: Alicja Braczko

    Gdański Uniwersytet Medyczny, Wydział Lekarski

  39. Computational alchemy and experimental validation: a hybrid approach for designing new antimicrobial peptides

    Call: PRELUDIUM 22 , Panel: NZ1

    Principal investigator: Piotr Chyży

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  40. The effect of Tcf7l2 knockout on excitation/inhibition balance in neuronal circuits of the thalamus

    Call: PRELUDIUM 22 , Panel: NZ3

    Principal investigator: Katarzyna Hryniewiecka

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  41. Multiparameter analysis of co-inhibitory and co-stimulatory immune checkpoints and their role in the induction of immuno...

    Call: PRELUDIUM 22 , Panel: NZ6

    Principal investigator: dr Dorota Suszczyk

    Uniwersytet Medyczny w Lublinie

  42. Designing Active Inhibitors of SARS-CoV-2 Methyltransferases

    Call: PRELUDIUM 22 , Panel: NZ7

    Principal investigator: Alex Matsuda

    Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

  43. Efektywność nowatorskiej terapii inhibitorami JAK u pacjentów z reumatoidalnym zapaleniem stawów w odniesieniu do profil...

    Call: PRELUDIUM 22 , Panel: NZ5

    Principal investigator: Sylwia Biały

    Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

  44. Construction of Candida famata flavinogenic yeast strains with improved ability to produce riboflavin in medium with lig...

    Call: PRELUDIUM 22 , Panel: NZ1

    Principal investigator: Dominik Wojdyła

    Uniwersytet Rzeszowski, Kolegium Nauk Przyrodniczych

  45. Feel the chemistry if you're close enough - proximity-induced SuFEx ligation for mRNA biology and medicine

    Call: OPUS 25 , Panel: ST5

    Principal investigator: prof. Jacek Jemielity

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  46. Development of novel anti-cancer immunotherapy against mesothelioma comprising of oncolytic adenovirus vectors armed wit...

    Call: SONATA 18 , Panel: NZ7

    Principal investigator: dr Łukasz Kuryk

    Narodowy Instytut Zdrowia Publicznego PZH - Państwowy Instytut Badawczy

  47. Development of a cell-based assay for screening of SARS-CoV-2 PLpro inhibitors

    Call: SONATA 18 , Panel: NZ6

    Principal investigator: dr Wioletta Rut

    Politechnika Wrocławska

  48. Effects of tyrosine kinase inhibitors on Syk pathway in eNOS-based platelet subpopulations and on endothelial barrier in...

    Call: POLONEZ BIS 3 , Panel: NZ7

    Principal investigator: dr hab. Aneta Radziwon-Balicka

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  49. Targeted inhibition of hypusination pathway

    Call: OPUS 24 , Panel: NZ7

    Principal investigator: dr Przemysław Grudnik

    Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

  50. Identification of key structural elements of immunomodulatory proteins - inhibitors of antigenic peptide transporter TAP...

    Call: SONATA 18 , Panel: NZ7

    Principal investigator: dr Natalia Karska

    Uniwersytet Gdański, Wydział Chemii

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