Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Chemo-genetic investigation of the role of inhibitory interneurons containing somatostatin in cerebral cortex plasticity

2015/17/B/NZ4/02016

Keywords:

interneurons neuroplasticity learning barrel cortex inhibition chemogenetics

Descriptors:

  • NZ3_6: Cell neurobiology
  • NZ4_9: Systems neurobiology
  • NZ4_10: Neuroimaging and computational neuroscience

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Małgorzata Kossut 

Number of co-investigators in the project: 6

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 1 311 560 PLN

Project start date (Y-m-d): 2016-03-16

Project end date (Y-m-d): 2020-08-15

Project duration:: 53 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Monitor Dell.
  2. System do monitorowania stanu zwierzęcia (80 000 PLN)
  3. Wysokoobrotowa wiertarka stereotaktyczna.
  4. Autoklaw Extender Plus.
  5. Nanoinjektor (25 000 PLN)
  6. generator tlenu (6 000 PLN)
  7. Stymulator wibryss (24 000 PLN)
  8. oscyloskop (13 000 PLN)
  9. Ph-metr/jonometr stołowy Seven Compact.
  10. komputer z monitorem (2 szt.) (10 000 PLN)
  11. Fluovac, ekstraktor środka anestetycznego z powietrza.

Information in the final report

  • Publication in academic press/journals (5)
  1. Application of the DREADD technique in biomedical brain research.
    Authors:
    Dobrzanski G, Kossut M.
    Academic press:
    Pharmacological Reports (rok: 2017, tom: 69(2), strony: 213-221), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.015. - link to the publication
  2. Learning-induced plasticity in the barrel cortex is disrupted by inhibition of layer 4 somatostatin-containing interneurons *
    Authors:
    Dobrzanski G1, Lukomska A1, Zakrzewska R1, Posluszny A1, Kanigowski D2, Urban-Ciecko J2, Liguz-Lecznar M1, Kossut M1*
    Academic press:
    BBA Molecular Cell Research (rok: 2021, tom: 1869(1), strony: 119146), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbamcr.2021.119146 - link to the publication
  3. Somatostatin and Somatostatin-Containing Neurons in Shaping Neuronal Activity and Plasticity.
    Authors:
    Liguz-Lęcznar M.,Urban-Ciecko J., Kossut M.
    Academic press:
    Frontiers in Neurol Circuits (rok: 2016, tom: 10, strony: 48), Wydawca: Frontiers media SA
    Status:
    Published
    DOI:
    10.3389/fncir.2016.00048. - link to the publication
  4. Somatostatin receptors (SSTR1-5) on inhibitory interneurons in the barrel cortex
    Authors:
    Lukomska Agnieszka, Dobrzanski Grzegorz, Liguz-Lecznar Monika, Kossut Malgorzata
    Academic press:
    Brain Structure and Function (rok: 2019, tom: 2259(1), strony: 387-401), Wydawca: Springer Science + Busienss Media
    Status:
    Published
    DOI:
    10.1007/s00429-019-02011-7 - link to the publication
  5. Somatostatin receptors in the brain
    Authors:
    Łukomska Agnieszka,Dobrzański Grzegorz,Liguz -Lęcznar Monika,Kossut Małgorzata
    Academic press:
    Postępy Biochemii (rok: 2018, tom: 64(2-3), strony: 213-221), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    Brak - link to the publication

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