Projects funded by the NCN

Covalent inhibiors of bacterial ureases - design, activity and mode of binding

Call: PRELUDIUM 9 , Panel: NZ1

Principal investigator: dr Katarzyna Macegoniuk

Politechnika Wrocławska, Wydział Chemiczny

Synthesis and study of anticancer activities and affinities to kinesin of selected sandwich and half-sandwich organometa...

Call: OPUS 9 , Panel: ST5

Principal investigator: dr hab. Damian Plażuk

Uniwersytet Łódzki, Wydział Chemii

Synthesis of fluorogenic substrates, inhibitors and activity-based probes of human neutrophil proteinase NSP4 and its ev...

Call: OPUS 8 , Panel: ST5

Principal investigator: prof. Adam Lesner

Uniwersytet Gdański, Wydział Chemii

Design and synthesis of probes for RabGGTase profiling and their application for identification of the site of phosphono...

Call: SONATA BIS 4 , Panel: ST5

Principal investigator: dr hab. Katarzyna Błażewska

Politechnika Łódzka, Wydział Chemiczny

Study of casein kinase CK2 inhibition mechanisms

Call: OPUS 1 , Panel: ST5

Principal investigator: prof. Maria Bretner

Politechnika Warszawska, Wydział Chemiczny, Wydział Chemiczny

Design and synthesis of phosphoroorganic antagonists of BIR domain of apoptosis inhibitor proteins (IAP)

Call: PRELUDIUM 7 , Panel: ST5

Principal investigator: dr Agnieszka Łupicka-Słowik

Politechnika Wrocławska, Wydział Chemiczny

Novel polyelectrolytes as potential inhibitors of HSV-1 virus - synthesis, properties and mechanism of action

Call: OPUS 7 , Panel: ST5

Principal investigator: prof. Maria Nowakowska

Uniwersytet Jagielloński, Wydział Chemii

Design, chemical synthesis and biological activity of inhibitors of matriptase-2.

Call: PRELUDIUM 7 , Panel: ST5

Principal investigator: Agata Gitlin-Domagalska

Uniwersytet Gdański, Wydział Chemii

Structure optimization of inhibitor for paracaspase MALT1

Call: PRELUDIUM 6 , Panel: ST5

Principal investigator: dr Paulina Kasperkiewicz

Politechnika Wrocławska, Wydział Chemiczny

Studies on the metal ions impact on the structure and functions of peptidic inhibitors of aggregation of proteins involv...

Call: OPUS 1 , Panel: ST5

Principal investigator: dr Marek Łuczkowski

Uniwersytet Wrocławski, Wydział Chemii

Design and synthesis of acylpeptide hydrolase inhibitors as potential inducers of apoptosis in tumor cells

Call: PRELUDIUM 5 , Panel: ST5

Principal investigator: Maciej Walczak

Politechnika Wrocławska, Wydział Chemiczny

Design and synthesis of selective and irreversible inhibitors of HAT protease.

Call: PRELUDIUM 5 , Panel: ST5

Principal investigator: Marcin Skoreński

Politechnika Wrocławska, Wydział Chemiczny

RNA chaperone activity of HIV-2 Gag and nuclocapsid proteins: implications for the design of the new retroviral inhibito...

Call: SONATA 1 , Panel: NZ1

Principal investigator: dr Katarzyna Pachulska-Wieczorek

Instytut Chemii Bioorganicznej PAN

New methods for mRNA 5' end labeling and examples of their application in studies on RNA metabolism and searching for in...

Call: OPUS 5 , Panel: ST5

Principal investigator: dr hab. Jacek Jemielity

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Morita-Baylis-Hillman adducts as substrates in the synthesis of biologically active organophosphorus compounds

Call: OPUS 5 , Panel: ST5

Principal investigator: dr hab. Artur Mucha

Politechnika Wrocławska, Wydział Chemiczny

Design, chemical synthesis and enzymatic evaluation of peptidic substrates and inhibitors of cathepsin C

Call: PRELUDIUM 4 , Panel: ST5

Principal investigator: dr Monika Łęgowska

Uniwersytet Gdański, Wydział Chemii

Synthesis and preliminary studies on biological activity of glycosyltransferases natural substrates analogues, derivativ...

Call: PRELUDIUM 4 , Panel: ST5

Principal investigator: Roman Komor

Politechnika Śląska, Wydział Chemiczny

Synthesis and analysis of potential furin inhibitors in the development of the new therapeutic strategies against viral ...

Call: PRELUDIUM 4 , Panel: ST5

Principal investigator: Monika Lewandowska-Goch

Uniwersytet Gdański, Wydział Chemii

Diaminophosphonates as specific inhibitors of Neisseria meningitidis aminopeptidase N - synthesis and biological activit...

Call: PRELUDIUM 3 , Panel: ST5

Principal investigator: Ewelina Węglarz-Tomczak

Politechnika Wrocławska, Wydział Chemiczny

Organometallic inhibitors of tubulin polymerisation. Synthesis, anticancer activities and tubulin affinities.

Call: OPUS 3 , Panel: ST5

Principal investigator: dr hab. Damian Plażuk

Uniwersytet Łódzki, Wydział Chemii

Modifications of aglycones of leucomycins via Michael addition and Huisgen dipolar cycloaddition as a new routes of synt...

Call: SONATA BIS 1 , Panel: ST5

Principal investigator: dr hab. Piotr Przybylski

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

Identification of amino acid residues located in positions P7 and P8 of model inhibitor of proprotein convertases that d...

Call: PRELUDIUM 3 , Panel: ST5

Principal investigator: Izabela Małuch

Uniwersytet Gdański, Wydział Chemii

Synthesis of mononucleotide N2,N2,7-trimethylguanosine cap analogues as translation inhibitors in Ascaris suum

Call: PRELUDIUM 3 , Panel: ST5

Principal investigator: dr Karolina Piecyk

Uniwersytet Warszawski, Wydział Chemii

Design, synthesis and biological evaluation of Steroid Sulfatase Inhibitors based on organophosphorus compounds.

Call: SONATA 2 , Panel: NZ7

Principal investigator: dr Sebastian Demkowicz

POLITECHNIKA GDAŃSKA

Design and synthesis of new rifampicin analogs as a source of effective bacterial RNA polymerase inhibitors

Call: OPUS 2 , Panel: ST5

Principal investigator: dr hab. Piotr Przybylski

Uniwersytet im. Adama Mickiewicza, Wydział Chemii

Design and Development of Serine Hydroxymethyltransferase-2 (SHMT2) Inhibitors Blocking Tumor Growth

Call: SONATA BIS 13 , Panel: NZ7

Principal investigator: dr hab. Miłosz Ruszkowski

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Synthesis and biological activity evaluation of new hybrid derivatives of tacrine and melatonin as potential cholinester...

Call: OPUS 2 , Panel: ST5

Principal investigator: dr Anna Zawadzka

Uniwersytet Warszawski, Wydział Chemii

Search for novel IKK-β inhibitors in the context of diseases with neuroinflammatory origin – structure-based drug design...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Emilia Sługocka

Uniwersytet Jagielloński, Collegium Medicum

The design and development of the peptide inhibitors library targeting Zn(II)-binding site of matrix metalloproteinases ...

Call: PRELUDIUM 22 , Panel: ST5

Principal investigator: Paulina Potok

Uniwersytet Wrocławski, Wydział Chemii

Designing Active Inhibitors of SARS-CoV-2 Methyltransferases

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Alex Matsuda

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Computational deciphering of pro-ferroptotic cell death protein machinery as a fundamental step in the search for therap...

Call: SONATA BIS 12 , Panel: ST4

Principal investigator: dr Karolina Mikulska-Rumińska

Uniwersytet Mikołaja Kopernika w Toruniu, Wydział Fizyki, Astronomii i Informatyki Stosowanej

Structure-guided design of histone demethylase inhibitors for cancer therapy.

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Piotr Małecki

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Inhibiting the Mitochondrial Intermembrane Space Assembly pathway as a newapproach to prevent metabolic reprogramming of...

Call: OPUS 22 , Panel: NZ5

Principal investigator: dr hab. Carlo Vascotto

Instytut Hematologii i Transfuzjologii

Search for Inhibitors of Human δ1-Pyrroline-5-Carboxylate Reductase 1 (PYCR1) as Lead Molecules for the Development of N...

Call: OPUS 22 , Panel: NZ7

Principal investigator: dr hab. Miłosz Ruszkowski

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Blocking the TNF-TNFR2 interactions as a novel approach to the ovarian carcinoma treatment

Call: OPUS 21 , Panel: NZ7

Principal investigator: prof. Sylwia Rodziewicz-Motowidło

Uniwersytet Gdański, Wydział Chemii

Design of high selective and safe juvenile hormone epoxide hydrolases inhibitors targeting selected pests based on the c...

Call: OPUS 20 , Panel: ST4

Principal investigator: dr hab. Artur Góra

Politechnika Śląska, Centrum Biotechnologii

Novel L-asparaginases as potential therapeutic agents and antimicrobial targets: structural and functional studies of en...

Call: OPUS 19 , Panel: NZ1

Principal investigator: prof. Mariusz Jaskólski

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Inhalable polymeric delivery systems of antibiotics and quorum sensing inhibitors for the treatment of respiratory infec...

Call: OPUS 18 , Panel: ST5

Principal investigator: prof. Elżbieta Pamuła

Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie, Wydział Inżynierii Materiałowej i Ceramiki

Molecular mechanisms, signal transduction and inhibition of PEBP1-15LOX protein complex triggering the ferroptotic cell ...

Call: SONATA 15 , Panel: ST4

Principal investigator: dr Karolina Mikulska-Rumińska

Uniwersytet Mikołaja Kopernika w Toruniu, Wydział Fizyki, Astronomii i Informatyki Stosowanej

Novel, rationally designed modulators of glycosomal import of enzymes in Trypanosoma parasites

Call: OPUS 16 , Panel: NZ7

Principal investigator: dr hab. Maciej Dawidowski

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny

Gold and silver nanoparticles as carriers for delivery of 5' end mRNA cap analogues with potential therapeutical applica...

Call: OPUS 16 , Panel: ST5

Principal investigator: dr hab. Marzena Jankowska-Anyszka

Uniwersytet Warszawski, Wydział Chemii

Histidine Biosynthetic Pathway in Plants: Structural and Functional Studies as a Framework for the Design of Inhibitors ...

Call: SONATA 14 , Panel: NZ1

Principal investigator: dr hab. Miłosz Ruszkowski

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

De novo designed, structurally extended peptide foldamers and their use for construction of PD-1/PD-L1 interaction inhib...

Call: OPUS 16 , Panel: ST5

Principal investigator: dr hab. Łukasz Berlicki

Politechnika Wrocławska

CP protease of the O'nyong-nyong virus: substrate profiling, design and synthesis of inhibitors and activity-based probe...

Call: OPUS 15 , Panel: NZ6

Principal investigator: dr hab. Marcin Sieńczyk

Politechnika Wrocławska

Organometallic compounds as selective inhibitors of selected multidrug resistance proteins

Call: OPUS 15 , Panel: ST5

Principal investigator: dr hab. Damian Plażuk

Uniwersytet Łódzki, Wydział Chemii

Polymeric inhibitors of Zika virus

Call: OPUS 14 , Panel: ST5

Principal investigator: prof. Maria Nowakowska

Uniwersytet Jagielloński, Wydział Chemii

Inhibitors of BTLA-HVEM complex formation as potential targets for cancer immunotheraphy

Call: SONATA 13 , Panel: ST5

Principal investigator: dr Marta Spodzieja

Uniwersytet Gdański, Wydział Chemii

Small-molecule inhibitors for characterization of the interaction between extracellular domains of Programmed Cell Death...

Call: MAESTRO 9 , Panel: ST5

Principal investigator: prof. Tadeusz Holak

Uniwersytet Jagielloński, Wydział Chemii

Aminophosphonates bearing fluorine atoms as inhibitors odf aminopeptideses and their potential application for determina...

Call: HARMONIA 9 , Panel: ST5

Principal investigator: prof. Paweł Kafarski

Politechnika Wrocławska

Design of new small molecular regulators (inhibitors, activators) of the catalytic activity of adenylate kinases. Molecu...

Call: OPUS 13 , Panel: ST4

Principal investigator: dr Anna Kozakiewicz-Piekarz

Uniwersytet Mikołaja Kopernika w Toruniu, Wydział Chemii