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1. Allosteric and allosteric-orthosteric bitopic ligands of histamine receptor H4 as a way to increase selectivity and bias…

Principal investigator: prof. Sławomir Hubert Filipek

Uniwersytet Warszawski, Wydział Chemii

Call: OPUS 23, Panel: NZ7

2. Molecular modeling of allosteric binding and allosteric-orthosteric coupling in cannabinoid receptor CB1

Principal investigator: Jakub Jakub Jakowiecki

Uniwersytet Warszawski, Wydział Chemii

Call: PRELUDIUM 12, Panel: NZ1

3. Allosteric regulation of cathepsins and procathepsins enzymatic activity by glycosaminoglycans and their mimetics

Principal investigator: dr Krzysztof Kamil Bojarski

Politechnika Gdańska, Wydział Chemiczny

Call: SONATINA 7, Panel: ST4

4. New positive allosteric modulators of EAAT2 glutamate transporter as candidates for treatment of neurological and psychi…

Principal investigator: prof. Krzysztof Tomasz Kamiński

Uniwersytet Jagielloński, Collegium Medicum

Call: OPUS 23, Panel: NZ7

5. Molecular Mechanisms of GABAA Receptor Allosteric Modulation by pH Level.

Principal investigator: Michał Adam Michałowski

Uniwersytet Wrocławski, Wydział Nauk Biologicznych

Call: PRELUDIUM 15, Panel: NZ1

6. Molecular mechanisms of the allosteric communication in thymidylate synthase

Principal investigator: dr Jan Marcin Ludwiczak

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Call: PRELUDIUM 14, Panel: NZ1

7. Using X-ray crystallography for localization of the sites of binding of allosteric inhibitors and activators within the …

Principal investigator: Julia Witkowska

Uniwersytet Gdański, Wydział Chemii

Call: PRELUDIUM 9, Panel: NZ1

8. The effects of positive allosteric modulators of alpha7 nicotinic acetylcholine receptors on complex cognitive processes…

Principal investigator: dr hab. Agnieszka Anna Nikiforuk

Instytut Farmakologii PAN

Call: OPUS 4, Panel: NZ7

9. Probing the selectivity of zinc allosteric modulation in various serotonin receptor subtypes

Principal investigator: Grzegorz Marek Satała

Instytut Farmakologii PAN

Call: PRELUDIUM 3, Panel: NZ7

10. Characterization of nucleic acids as the allosteric activators of PAD4

Principal investigator: dr Tomasz Kantyka

Uniwersytet Jagielloński

Call: OPUS 27, Panel: NZ5

11. Stop the biting: tracking the insecticide-mediated allosteric changes in voltage-gated sodium channels and design of sel…

Principal investigator: dr Beata Niklas

Uniwersytet Mikołaja Kopernika, Wydział Nauk Biologicznych i Weterynaryjnych

Call: PRELUDIUM 20, Panel: NZ3

12. Exploring the allosteric regulation of the SARS CoV-2 hydrolases using methyl-TROSY NMR spectroscopy - in search of nove…

Principal investigator: prof. Wiktor Adam Koźmiński

Uniwersytet Warszawski, Wydział Chemii

Call: OPUS 19, Panel: ST4

13. Evaluation of therapeutic role of novel positive allosteric modulators of GABA-A receptor in ischemic brain stroke

Principal investigator: dr Monika Emilia Marcinkowska

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum

Call: SONATA BIS 8, Panel: NZ7

14. Allosteric inhibitors of proteasome - optimization of the structure of PR39 analogs in order to achieve greater efficien…

Principal investigator: Małgorzata Giżyńska

Uniwersytet Gdański, Wydział Chemii

Call: PRELUDIUM 12, Panel: ST5

15. Allosteric photoregulation in macrocyclic hosts

Principal investigator: dr Volodymyr Sashuk

Instytut Chemii Fizycznej Polskiej Akademii Nauk

Call: OPUS 12, Panel: ST5

16. Interdomain allosteric communication in Rad50 protein and its role in genome maintence by Mre11 complex

Principal investigator: prof. Artur Krężel

Uniwersytet Wrocławski, Wydział Biotechnologii

Call: OPUS 11, Panel: NZ1

17. Investigation of the molecular mechanisms of anti-leukemic activity of SK053, a small molecule compound targeting enzyme…

Principal investigator: prof. Dominika Anna Nowis

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Call: SONATA BIS 3, Panel: NZ5

18. Structural studies based on low sequence similarity of G protein-coupled receptors activated by hormones and allosteric …

Principal investigator: dr Dorota Latek

Uniwersytet Warszawski, Wydział Chemii

Call: SONATA 4, Panel: NZ1

19. Toward understanding allosteric regulation of the proteasome activity

Principal investigator: dr hab. Elżbieta Jankowska

Uniwersytet Gdański, Wydział Chemii

Call: OPUS 1, Panel: ST5

20. Analysis of the structural and functional mechanisms of action of the nicotinic receptors modulators.

Principal investigator: dr Katarzyna Małgorzata Targowska-Duda

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej

Call: SONATA 5, Panel: NZ7

Principal investigator: prof. Józef Adam Liwo

Uniwersytet Gdański, Wydział Chemii

Call: OPUS 26, Panel: ST4

22. Light-induced photoreceptor morphological changes – Towards objective and impartial diagnostics in ophthalmology

Principal investigator: dr Humberto Couto Fernandes

Instytut Chemii Fizycznej Polskiej Akademii Nauk, Międzynarodowe Centrum Badań Oka

Call: OPUS 26, Panel: NZ7

23. The evaluation of the efficacy of alpha7 nicotinic acetylcholine receptor ligands in rat models of autism

Principal investigator: dr hab. Agnieszka Anna Nikiforuk

Instytut Farmakologii PAN

Call: OPUS 12, Panel: NZ7

24. The effects of ligands of the alpha7 nicotinic acetylcholine receptors on complex cognitive processes and social behavio…

Principal investigator: Agnieszka Teresa Potasiewicz

Instytut Farmakologii PAN

Call: PRELUDIUM 8, Panel: NZ7

25. Hydration effects in protein kinases

Principal investigator: dr Piotr Mikołaj Setny

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Call: SONATA 6, Panel: ST4

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