Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Molecular Mechanisms of GABAA Receptor Allosteric Modulation by pH Level.

2018/29/N/NZ1/02834

Keywords:

gaba receptor ion channel modulation ph proton allosteric binding site

Descriptors:

  • NZ1_4: Structural biology
  • NZ3_5: Molecular neurobiology
  • NZ2_10: Biological systems analysis, modelling and simulation

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Wrocławski, Wydział Nauk Biologicznych

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Michał Michałowski 

Number of co-investigators in the project: 2

Call: PRELUDIUM 15 - announced on 2018-03-15

Amount awarded: 175 600 PLN

Project start date (Y-m-d): 2019-02-04

Project end date (Y-m-d): 2023-02-03

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer do prowadzenia obliczen związanych z modelowaniem struktury białek. (29 520 PLN)
  2. Licencja na oprogramowanie Pymol (3 lata) (1 000 PLN)
  3. Wielostrzykawkowa pompa infuzyjna (30 000 PLN)
  4. Licencja na pakiet oprogramowania do modelownia molekularnego Schrodinger (1 rok) (20 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  1. The β2 subunit E155 residue as a proton sensor at the binding site on GABA type A receptors
    Authors:
    Michał A. Michałowski, Marta M. Czyżewska, Ilona Iżykowska, Jerzy W. Mozrzymas
    Academic press:
    European Journal of Pharmacology (rok: 2021, tom: 906, strony: 174293), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2021.174293 - link to the publication
  2. Mutations of α1F45 residue of GABAA receptor loop G reveal its involvement in agonist binding and channel opening/closing transitions.
    Authors:
    Marek Brodzki, Michał A.Michałowski, Michalina Gos, Jerzy W.Mozrzymas
    Academic press:
    Biochemical Pharmacology (rok: 2020, tom: 177, strony: 45305), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bcp.2020.113917 - link to the publication

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