Molecular Mechanisms of GABAA Receptor Allosteric Modulation by pH Level.
2018/29/N/NZ1/02834
Keywords
Descriptors
- NZ1_4: Biologia strukturalna
- NZ3_5: Neurobiologia molekularna
- NZ2_10: Modelowanie i symulacje biologiczne
Panel
NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution
Uniwersytet Wrocławski, Wydział Nauk Biologicznych
Voivodeship: dolnośląskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 2
Call
PRELUDIUM 15 – announced on 2018-03-15
- Amount awarded
- 175 600 PLN
- Project start date
- 2019-02-04
- Project end date
- 2023-02-03
- Project duration
- 48 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Komputer do prowadzenia obliczen związanych z modelowaniem struktury białek.. Cost: 29 520 PLN
- Licencja na oprogramowanie Pymol (3 lata). Cost: 1 000 PLN
- Licencja na pakiet oprogramowania do modelownia molekularnego Schrodinger (1 rok). Cost: 20 000 PLN
- Wielostrzykawkowa pompa infuzyjna. Cost: 30 000 PLN
Information in the final report
Publication in academic press/journals (2)
-
The β2 subunit E155 residue as a proton sensor at the binding site on GABA type A receptors
- Authors:
- Michał A. Michałowski, Marta M. Czyżewska, Ilona Iżykowska, Jerzy W. Mozrzymas
- Academic press:
- European Journal of Pharmacology (year: 2021, volume: 906, pages: 174293), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.ejphar.2021.174293 – link to the publication
-
Mutations of α1F45 residue of GABAA receptor loop G reveal its involvement in agonist binding and channel opening/closing transitions.
- Authors:
- Marek Brodzki, Michał A.Michałowski, Michalina Gos, Jerzy W.Mozrzymas
- Academic press:
- Biochemical Pharmacology (year: 2020, volume: 177, pages: 46036), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.bcp.2020.113917 – link to the publication