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Information on the principal investigator and host institution

Information of the project and the call

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The effects of positive allosteric modulators of alpha7 nicotinic acetylcholine receptors on complex cognitive processes.

2012/07/B/NZ7/01150

Keywords:

Cognition animal models nicotinic receptors allosteric modulation schizophrenia NMDA receptor

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Agnieszka Nikiforuk 

Number of co-investigators in the project: 3

Call: OPUS 4 - announced on 2012-09-15

Amount awarded: 365 055 PLN

Project start date (Y-m-d): 2013-07-12

Project end date (Y-m-d): 2016-07-11

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Przyłącze przewodów do obsługi klatek instrumentalnych.
  2. kamera (2 szt.) (2 000 PLN)
  3. kamera do rejestracji zachowań zwierząt (323 PLN)
  4. Interfejs do obsługi klatek instrumentalnych.
  5. klatka instrumentalna do testu 5-CSRTT, typu MED-NP5L-D1 (Med Associates) (2 szt.) (44 000 PLN)
  6. komputer stacjonarny do użytku biurowego (4 000 PLN)
  7. Rejestrator zaglądnięć do klatek instrumentalnych.

Information in the final report

  • Publication in academic press/journals (8)
  • Articles in post-conference publications (8)
  1. Positive allosteric modulators of alpha 7 nicotinic acetylcholine receptors reverse ketamine-induced schizophrenia-like deficits in rats
    Authors:
    Agnieszka Nikiforuk, Tomasz Kos, Małgorzata Hołuj, Agnieszka Potasiewicz, Piotr Popik
    Academic press:
    Neuropharmacology (rok: 2016, tom: 101, strony: 389-400), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuropharm.2015.07.034 - link to the publication
  2. The combination of memantine and galantamine improves cognition in rats: The synergistic role of the 7 nicotinic acetylcholine and NMDA receptors
    Authors:
    Agnieszka Nikiforuk∗, Agnieszka Potasiewicz, Tomasz Kos, Piotr Popik
    Academic press:
    Behavioural Brain Research (rok: 2016, tom: 313, strony: 214-218), Wydawca: elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbr.2016.07.023 - link to the publication
  3. The effects of acute and repeated administration of ketamine on attentional performance in the five choice serial reaction time task in rats
    Authors:
    Nikiforuka A, Popik P
    Academic press:
    Eur. Neuropsychopharmacol (rok: 2014, tom: 24, strony: 1381–1393), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.euroneuro.2014.04.007 - link to the publication
  4. 3-Furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of the α7 nicotinic receptor, reverses schizophrenia-like cognitive and social deficits in rats
    Authors:
    Agnieszka Potasiewicz, Małgorzata Hołuj, Tomasz Kos, Piotr Popik, Hugo R. Arias, and Agnieszka Nikiforuk
    Academic press:
    Neuropharmacology (rok: 2017, tom: 113, strony: 188-197), Wydawca: elsevier
    Status:
    Published
    DOI:
    10.002. - link to the publication
  5. Pro-cognitive activity in rats of 3-furan-2-yl-N-p-tolylacrylamide, a positive allosteric modulator of the α7 nicotinic acetylcholine receptor
    Authors:
    A. Potasiewicz, T. Kos, F. Ravazzini, G. Puia, H. R. Arias, P Popik and A. Nikiforuk
    Academic press:
    British Journal of Pharmacology (rok: 2015, tom: 172, strony: 5123-5135), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/bph.13277 - link to the publication
  6. Positive allosteric modulation of alpha 7 nicotinic acetylcholine receptors enhances recognition memory and cognitive flexibility in rats.
    Authors:
    Nikiforuk A, Kos T, Potasiewicz A and Popik P.
    Academic press:
    European Neuropsychopharmacology (rok: 2015, tom: 25, strony: 1300-1313), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.euroneuro.2015.04.018 - link to the publication
  7. Serotonergic and Cholinergic Strategies as Potential Targets for the Treatment of Schizophrenia
    Authors:
    Agnieszka Nikiforuk
    Academic press:
    Current Pharmaceutical Design (rok: 2016, tom: 22, strony: 2093-116), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/138161282266616012711375 - link to the publication
  8. Stimulation of nicotinic acetylcholine alpha7 receptors rescue schizophrenia-like cognitive impairments in rats.
    Authors:
    Agnieszka Potasiewicz , Agnieszka Nikiforuk , Małgorzata Hołuj and Piotr Popik
    Academic press:
    Journal of Psychopharmacology (rok: 2017, tom: 31, strony: 260-271), Wydawca: SAGE
    Status:
    Published
    DOI:
    10.1177/0269881116675509 - link to the publication
  1. Activation and positive allosteric modulation of alpha 7 nicotinic acetylcholine receptors reverse ketamine-induced cognitive inflexibility in rats
    Authors:
    Nikiforuk Agnieszka ; Potasiewicz Agnieszka; Popik Piotr
    Conference:
    EBBS (European Brain Behaviour Society) & EBPS (European Behavioural Pharmacology Society) Joint Meeting (rok: 2015, ), Wydawca: EBBS/EBPS http://ebbsebpsverona2015jointmeeting.info/
    Data:
    konferencja 12-15 wrzesień
    Status:
    Published
  2. The effects of the positive allosteric modulator of a7- nAChRs in cognitive tasks in rats.
    Authors:
    Nikiforuk A, Potasiewicz A, Popik P
    Conference:
    11th Göttingen Meeting of the German Neuroscience Society (rok: 2015, ), Wydawca: German Neuroscience Society
    Data:
    konferencja 18-21 marzec
    Status:
    Published
  3. Alpha 7 nicotinic acetylcholine receptors agonist reverse cognitive and sensorimotor gating deficits in a schizophrenia-like model in rats
    Authors:
    Potasiewicz Agnieszka; Nikiforuk Agnieszka; Kos Tomasz ; Piotr Popik
    Conference:
    EBBS (European Brain Behaviour Society) & EBPS (European Behavioural Pharmacology Society) Joint Meeting (rok: 2015, ), Wydawca: EBBS/EBPS http://ebbsebpsverona2015jointmeeting.info/
    Data:
    konferencja 12-15 wrzesień
    Status:
    Published
  4. Positive allosteric modulators of ɑ7 nicotinic acetylcholine receptor enhance memory processes
    Authors:
    Potasiewicz A, Nikiforuk A, Krawczyk A, Kos T, Popik P
    Conference:
    2nd Central European Biomedical Congress (rok: 2016, ), Wydawca: Central European Biomedical Congress 2016 www.cebc2016.com
    Data:
    konferencja 15-18 czerwiec
    Status:
    Published
  5. The effects of positive allosteric modulator of α7 nicotinic receptors on cognitive and sensorimotor gating deficits in a schizophrenia-like model in rats.
    Authors:
    Agnieszka Potasiewicz, Agnieszka Nikiforuk, Małgorzata Hołuj, Piotr Popik
    Conference:
    5th Biennial Schizophrenia International Research Society (SIRS) Conference (rok: 2016, ), Wydawca: npj Schizophrenia 2
    Data:
    konferencja 2-6 kwiecień
    Status:
    Published
    DOI:
    link to the publication
  6. PAM-2, a positive allosteric modulator of the α7 nAChRs, reverses schizophrenia-like cognitive deficits in rats
    Authors:
    Agnieszka Nikiforuk, Agnieszka Potasiewicz, Tomasz Kos, Małgorzata Hołuj, Piotr Popik, Hugo R Arias
    Conference:
    5th Biennial Schizophrenia International Research Society (SIRS) Conference (rok: 2016, ), Wydawca: npj Schizophrenia 2
    Data:
    konferencja 2-6 kwiecień
    Status:
    Published
  7. Positive allosteric modulation of nicotinic receptors: A new hope to treat cognitive deficits?
    Authors:
    Potasiewicz A, Nikiforuk A, Popik P.
    Conference:
    3rd International Seminar on Behavioral Methods, Szczyrk, Poland (rok: 2014, ), Wydawca: Acta Neurobiol. Exp.
    Data:
    konferencja 18–20 wrzesień
    Status:
    Published
  8. The role of alpha 7 nicotinic acetylcholine receptors in the modulation of attention in rats
    Authors:
    Agnieszka Potasiewicz, Agnieszka Nikiforuk, Piotr Popik
    Conference:
    NEURONUS 2016 IBRO & IRUN Neuroscience Forum (rok: 2016, ), Wydawca: www.neuronusforum.pl
    Data:
    konferencja 22-24 kwiecień 2016
    Status:
    Published

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