Search results

1. Novel 2,4-disubstituted pyridine derivatives - synthesis, antimycobacterial activity in vitro, pharmacophore model, mole…

Principal investigator: dr hab. Katarzyna Małgorzata Gobis

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

Call: OPUS 13, Panel: NZ7

2. The role of EZH2 activity in the development of resistance to targeted therapy in melanoma

Principal investigator: dr Michał Jerzy Woźniak

Uniwersytet Medyczny w Łodzi

Call: OPUS 28, Panel: NZ7

3. Tick-borne encephalitis virus protease as a molecular target for novel inhibitors and activity-based probes

Principal investigator: dr Renata Grzywa

Politechnika Wrocławska

Call: OPUS 28, Panel: NZ6

4. Novel broad-spectrum central nervous system active substances: optimization of their multi-target profile

Principal investigator: dr hab. Agnieszka Anna Kaczor

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

Call: OPUS 22, Panel: NZ7

5. Novel combination therapies of pulmonary arterial hypertension targeting blockade of peripheral cannabinoid CB1 receptor…

Principal investigator: prof. Barbara Malinowska

Uniwersytet Medyczny w Białymstoku

Call: OPUS 21, Panel: NZ7

6. Parallel quantitative evaluation of targetability, cellular uptake, and intracellular drug release for the establishment…

Principal investigator: prof. Adolfo Rivero Müller

Uniwersytet Medyczny w Lublinie, Wydział Nauk Medycznych

Call: OPUS 20 (LAP), Panel: ST5

7. Suppression of platelet activation as a therapeutic target for patients with AERD (aspirin-exacerbated respiratory disea…

Principal investigator: prof. Lucyna Maria Mastalerz

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Lekarski

Call: OPUS 13, Panel: NZ5

8. Novel multi-target directed ligands combining cholinesterase inhibition and 5-HT6 antagonism - design, synthesis and pha…

Principal investigator: dr hab. Anna Karolina Więckowska

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Call: SONATA 12, Panel: NZ7

9. New 2(5H)-furanone derivatives with tailored hydrophobicity of substitutents - synthesis, molecular targets, mechanism o…

Principal investigator: prof. Krzysztof Zdzisław Walczak

Politechnika Śląska, Wydział Chemiczny

Call: OPUS 11, Panel: NZ7

10. Research on anti-C. albicans vaccine that applies targeting to dendritic cells and activation of Dectin-1 receptor.

Principal investigator: dr Tomasz Lipiński

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Call: OPUS 5, Panel: NZ6

11. Disruption of the posttranslational activation of the translation factor EF-P as a new target for antimicrobial agents.

Principal investigator: dr Piotr Wilk

Uniwersytet Jagielloński

Call: OPUS 27, Panel: NZ7

12. Activation of Staphylococcus aureus LytM autolysin as a potential target for antimicrobials development.

Principal investigator: dr hab. Izabela Sabała

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Call: OPUS 26, Panel: NZ1

13. The role of novel antibacterial agent with potential to target microbial community in respiratory disorders and identifi…

Principal investigator: dr Paulina Miernikiewicz

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Call: SONATA 19, Panel: NZ6

14. Evaluating the antibacterial activity of the bacteriophage protein targeting Staphylococcus aureus, including drug-resis…

Principal investigator: dr Zuzanna Maria Kaźmierczak

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Call: SONATA 19, Panel: NZ7

15. Biased multi-target ligands as tools for activity pattern analysis of G protein-coupled receptors in cancer cells

Principal investigator: dr Artur Wnorowski

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej

Call: SONATA 14, Panel: NZ7

16. Does DREADD and TrkB gene transfer targeted to selected motoneurons following spinal cord injury bring recovery of motor…

Principal investigator: prof. Małgorzata Hanna Skup

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Call: OPUS 16, Panel: NZ4

17. Determination of targets for peptidylarginine deiminase type 4 (PAD4) among complement system proteins and assessment of…

Principal investigator: dr Ewa Izabela Bielecka

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Call: HARMONIA 10, Panel: NZ1

18. Understanding the molecular basis of the regulation of activity of lysosome, a potential target of therapeutic intervent…

Principal investigator: prof. Magdalena Angelina Gabig-Cimińska

Uniwersytet Gdański, Wydział Biologii

Call: OPUS 14, Panel: NZ3

19. Determination of the mechanisms and potential targets for neuropathic pain therapy by investigating pharmacological inte…

Principal investigator: Anna Piotrowska-Murzyn

Instytut Farmakologii PAN

Call: PRELUDIUM 12, Panel: NZ7

20. Characteristics of neuropilin-1 (NRP1) as a target of antiangiogenic activity of immunomodulatory drugs in multiple myel…

Principal investigator: prof. Krzysztof Giannopoulos

Uniwersytet Medyczny w Lublinie, II Wydział Lekarski z Oddziałem Anglojęzycznym

Call: OPUS 7, Panel: NZ6

21. Inhibition of p21-Activated Kinase (PAK) as a new molecular target in the treatment of chronic myeloid leukemia (CML)

Principal investigator: dr hab. Sylwia Flis

Narodowy Instytut Leków

Call: OPUS 6, Panel: NZ7

22. Investigation of the molecular mechanisms of anti-leukemic activity of SK053, a small molecule compound targeting enzyme…

Principal investigator: prof. Dominika Anna Nowis

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Call: SONATA BIS 3, Panel: NZ5

23. Activation of endogenous pronociceptive mechanisms of opioid system as an important factors in the development of neurop…

Principal investigator: prof. Barbara Elżbieta Przewłocka

Instytut Farmakologii PAN

Call: MAESTRO 3, Panel: NZ4

24. Histamine H3/H4 receptors as the attractive target for the search of biologically active substances

Principal investigator: prof. Katarzyna Justyna Kieć-Kononowicz

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Call: MAESTRO 1, Panel: NZ4

25. Fungal bioactive substances with targeted pro-health potential - the role ofinteractions, bioavailability and bioavailab…

Principal investigator: prof. Michał Świeca

Uniwersytet Przyrodniczy w Lublinie, Wydział Nauk o Żywności i Biotechnologii

Call: OPUS 23, Panel: NZ9

26. Research of multifunctional compounds targeting neuroinflammation and cholinergic deficit in Alzheimer's disease

Principal investigator: prof. Kinga Aleksandra Sałat

Uniwersytet Jagielloński, Collegium Medicum

Call: OPUS 22 (LAP), Panel: NZ7

27. Supramolecular compounds and their complexes with carbon nanotubes as potential systems for targeted delivery of drugs

Principal investigator: dr Anna Jagusiak

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Lekarski

Call: SONATA 11, Panel: NZ1

28. Carbon nanotubes as magnetic nanocariers in the targeted chemotherapy

Principal investigator: dr hab. Sławomir Boncel

Politechnika Śląska, Wydział Chemiczny

Call: SONATA 3, Panel: ST5

29. Synthesis of new phthalocyanines for targeted photodynamic cancer therapy.

Principal investigator: dr Łukasz Andrzej Łapok

Uniwersytet Jagielloński, Wydział Chemii; Zespół Nanotechnologii Polimerów i Biomateriałów

Call: SONATA 2, Panel: ST5

30. Targeted Degradation of the MLL Complex in Leukemia: A PROTAC-Based Therapeutic Strategy

Principal investigator: dr Natalia Anna Skrzypczak

Fundacja Uniwersytetu im. Adama Mickiewicza

Call: SONATINA 9, Panel: ST5

31. Targeting the NS3 protease of neglected yellow fever-related Orthoflaviviruses

Principal investigator: dr hab. Paulina Maria Kasperkiewicz-Wasilewska

Politechnika Wrocławska

Call: OPUS 28 (LAP), Panel: NZ6

32. Directed screening and evaluation of novel bactericidal compounds active againsttubercle bacilli and Mycobacterium absce…

Principal investigator: prof. Jarosław Dziadek

Instytut Biologii Medycznej PAN

Call: OPUS 25, Panel: NZ7

33. Mitochondria-targeting conjugates as a new anticancer agents

Principal investigator: prof. Adam Włodzimierz Huczyński

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

Call: OPUS 21, Panel: ST4

34. The study on the molecular mechanisms of cytotoxic activity of new compounds ZOT5-1-Me and ZOT5-1-Et in an experimental …

Principal investigator: dr Paulina Anna Tokarz

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Call: SONATA 16, Panel: NZ7

35. Insights into biological activity and mechanism of action of novel styrylquinazoline derivatives as tyrosine kinase inhi…

Principal investigator: Katarzyna Anna Malarz

UNIWERSYTET ŚLĄSKI, Wydział Matematyki, Fizyki i Chemii

Call: PRELUDIUM 12, Panel: NZ7

36. Hyphenated separation techniques in the study of the molecular mechanisms of metabolic biotransformation of drugs for ta…

Principal investigator: dr Małgorzata Szultka-Młyńska

Uniwersytet Mikołaja Kopernika, Wydział Chemii

Call: SONATA 12, Panel: ST4

37. Polymer-based nanostructures modified with biologically active substances for selective accumulation and release of drug…

Principal investigator: Wioletta Sylwia Liwińska

Uniwersytet Warszawski, Wydział Chemii

Call: PRELUDIUM 10, Panel: ST5

38. Design and synthesis of probes for RabGGTase profiling and their application for identification of the site of phosphono…

Principal investigator: dr hab. Katarzyna Błażewska

Politechnika Łódzka, Wydział Chemiczny

Call: SONATA BIS 4, Panel: ST5

39. Modifiers of Muscleblind-like genes expression in health and disease.

Principal investigator: dr hab. Ewa Agnieszka Stępniak-Konieczna

Uniwersytet Przyrodniczy w Poznaniu, Wydział Rolnictwa, Ogrodnictwa i Biotechnologii

Call: SONATA BIS 12, Panel: NZ5

40. Application of bioconjugation strategy to the synthesis of anticancer Trojan horses

Principal investigator: dr hab. Michał Piotr Antoszczak

Uniwersytet im. Adama Mickiewicza w Poznaniu

Call: OPUS 28, Panel: ST5

41. Studies of nuclear 16O(γ, α)12C i 2H(γ ,p)n reactions at the High Intensity Gamma Source

Principal investigator: prof. Zenon Janas

Uniwersytet Warszawski, Wydział Fizyki

Call: OPUS 17, Panel: ST2

42. INNOvative antiSEPTic agents for a therapy with a broad spectrum of action

Principal investigator: dr Sebastian Kraszewski

Politechnika Wrocławska

Call: OPUS 10, Panel: NZ7

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