Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Supramolecular compounds and their complexes with carbon nanotubes as potential systems for targeted delivery of drugs

2016/21/D/NZ1/02763

Keywords:

supramolecular compounds (SC) mixed supramolecular compounds (MSC) Congo red (CR) carbon nanotubes (CNT) doxorubicin (DOX) cell cultures dispersing and shortening of carbon nanotubes targeted drug delivery antibacterial activity

Descriptors:

  • ST5_10: Functional materials/nanomaterials, nanoparticles
  • ST5_22:
  • NZ1_9: Biotechnology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Lekarski

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Anna Jagusiak 

Number of co-investigators in the project: 6

Call: SONATA 11 - announced on 2016-03-15

Amount awarded: 1 017 950 PLN

Project start date (Y-m-d): 2017-02-27

Project end date (Y-m-d): 2022-08-26

Project duration:: 66 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Cieplarka do hodowli komórkowych.
  2. lodówka.
  3. pojemnik do przechowywania próbek w ciekłym azocie.
  4. pipeta(0,5-5ml).
  5. Dysk zewnętrzny.
  6. pipeta(0,1-2,5).
  7. Mieszadło magnetyczne.
  8. Wytrząsarka z termoblokiem.
  9. DLS/SLS Aparat wykorzystujący dynamiczne rozpraszanie światła do pomiaru promienia hydrodynamicznego cząstek, masy cząsteczkowej, lepkości, stopnia agregacji wraz z komputerem i oprogramowaniem (340 000 PLN)
  10. Komora laminarna do pracy z cytostatykami wraz z lampą UV.
  11. Pipeta wielokanałowa, zmienna (0,1-1,2ml).
  12. Zamrażarka niskotemperaturowa.
  13. pipeta(2-20,20-200).

Information in the final report

  • Publication in academic press/journals (14)
  • Articles in post-conference publications (5)
  • Book publications / chapters in book publications (5)
  1. Adsorption of Evans blue and Congo red on carbon nanotubes and its influence on the fracture parameters of defective and functionalized carbon nanotubes studied using computational methods
    Authors:
    Jagusiak A., Goclon J., Panczyk T.
    Academic press:
    Applied Surface Science (rok: 2021, tom: 539, strony: 148236), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.apsusc.2020.148236 - link to the publication
  2. Interaction of Supramolecular Congo Red and Congo Red- Doxorubicin Complexes with Proteins for Drug Carrier Design
    Authors:
    Jagusiak A., Chłopaś K., Zemanek G., Kościk I., Roterman I.
    Academic press:
    Pharmaceutics (rok: 2021, tom: 13(12), strony: 2027), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ - link to the publication
  3. Impact of Doxorubicin on Self-Organization of Congo Red : Quantum Chemical Calculations and Molecular Dynamics Simulations.
    Authors:
    Klaudia Kwiecińska, Anna Stachowicz-Kuśnierz, Anna Jagusiak, Irena Roterman, Jacek Korchowiec
    Academic press:
    ACS Omega (rok: 2020, tom: Vol. 5, nr 31, strony: 19377-19384), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acsomega.0c01095 - link to the publication
  4. Albumin Binds Doxorubicin via Self−Assembling Dyes as Specific Polymolecular Ligands.
    Authors:
    Jagusiak A.; Chłopaś K.; Zemanek G.; Kościk I.; Skorek P.; Stopa B.
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23 (9), strony: 5033), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23095033 - link to the publication
  5. Amyloids, Congo red and apple-green effect
    Authors:
    Jagusiak A., Rybarska J., Konieczny L., Piekarska B., Stopa B., Chłopaś K., Zemanek G., Roterman I.
    Academic press:
    Acta Biochimica Polonica (rok: 2019, tom: 66, 1, strony: 39–46), Wydawca: Polish Biochemical Society
    Status:
    Published
    DOI:
    10.18388/abp.2018_2667 - link to the publication
  6. An outline of the use of supramolecular compounds in biology and medicine
    Authors:
    Jagusiak A.
    Academic press:
    Acta Biochimica Polonica (rok: 2019, tom: 66 (4), strony: 545-549), Wydawca: Polish Biochemical Society
    Status:
    Published
    DOI:
    10.18388/abp.2019_2910 - link to the publication
  7. Carbon Nanomaterials for Theranostic Use
    Authors:
    Koscik I., Jankowski D., Jagusiak A.
    Academic press:
    C Journal of Carbon Research (rok: 2022, tom: 8, strony: 3), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/c8010003 - link to the publication
  8. Interaction of Congo Red, Evans Blue and Titan Yellow with doxorubicin in aqueous solutions. A molecular dynamics study.
    Authors:
    Jagusiak A., Panczyk T.
    Academic press:
    Journal of Molecular Liquids (rok: 2019, tom: 279, strony: 640–648), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molliq.2019.02.012 - link to the publication
  9. Self-assembled supramolecular ribbon-like structures complexed to single walled carbon nanotubes as possible anticancer drug delivery systems
    Authors:
    Jagusiak A., Chlopas K., Zemanek G., Jemioła-Rzemińska M., Piekarska B., Stopa B., Pańczyk T.
    Academic press:
    Int. J. Mol. Sci. (rok: 2019, tom: 20(9), strony: article number: 2064), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20092064 - link to the publication
  10. Structure and Location of Protein Sites Binding Self-Associated Congo Red Molecules with Intercalated Drugs as Compact Ligands—Theoretical Studies
    Authors:
    Ptak-Kaczor M., Kwiecinska K., Korchowiec J., Chłopas K., Banach M., Roterman I., Jagusiak A.
    Academic press:
    Biomolecules (rok: 2021, tom: 11, strony: 501), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom11040501 - link to the publication
  11. Controlled Release of Doxorubicin from the DrugDelivery Formulation Composed of Single-Walled Carbon Nanotubes and Congo Red : A Molecular Dynamics Study and Dynamic Light Scattering Analysis.
    Authors:
    Anna Jagusiak, Katarzyna Chlopas, Grzegorz Zemanek, Pawel Wolski, Tomasz Panczyk
    Academic press:
    Pharmaceutics (rok: 2020, tom: Vol. 12, nr 7, strony: 622), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics12070622 - link to the publication
  12. Antibacterial Therapy by Ag+ Ions Complexed with Titan Yellow/Congo Red and Albumin during Anticancer Therapy of Urinary Bladder Cancer
    Authors:
    Jagusiak A., Gosiewski T., Romaniszyn D., Lasota M., Wi´sniewska A., Chłopas K., Ostrowska B., Koscik I., Bulanda M.
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 23), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23010026 - link to the publication
  13. Congo Red as a Supramolecular Carrier System for Doxorubicin: An Approach to Understanding the Mechanism of Action.
    Authors:
    Kwiecinska K.; Stachowicz-Kusnierz A.; Korchowiec B.; Roman M.; Kwiatek W.M.; Jagusiak A.; Roterman I.; Korchowiec J.
    Academic press:
    Int. J. Mol. Sci. (rok: 2022, tom: 23 (16), strony: 8935), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23168935 - link to the publication
  14. Property of a new prussian blue bounded iron complex able to peroxidate non-saturated fatty acids with a tendency to create conditions that may encourage ferroptosis
    Authors:
    Lasota M., Rybarska J., Konieczny L., Zemanek G., Zagajewski J., Chłopaś K., Jankowski D., Kościk I., Skulska-Birgiel A., Wiśniewska A., Iciek M., Jasek-Gajda E., Jasińska M., Jagusiak A.
    Academic press:
    Journal of Physiology and Pharmacology (rok: 2022, tom: 73, 5, strony: 673-686), Wydawca: Department of Physiology
    Status:
    Published
    DOI:
    10.26402/jpp.2022.5.10 - link to the publication
  1. The role of self-assembled Congo red complexed with albumin or carbon nanotubes as a carrier of drugs (dasatinib or doxorubicin) in anticancer therapy
    Authors:
    A. Jagusiak, M. Lasota, G. Zemanek, D. Jankowski, I. Koscik
    Conference:
    25th IUBMB - 46th FEBS – 15th PABMB Congress The Biochemistry Global Summit" (rok: 2022, ), Wydawca: FEBS Open Bio 12 (Suppl. S1)
    Data:
    konferencja 9-14 Lipiec 2022
    Status:
    Published
  2. The role of self-assembled Congo red complexed with doxorubicin in reducing the dose of the drug
    Authors:
    Jagusiak A., Kwiecinska K., Ostrowska B., Roman M.
    Conference:
    44th FEBS Congress From molecules to living systems" (rok: 2019, ), Wydawca: FEBS OPEN BIO 9 (Suppl. 1)
    Data:
    konferencja 6-11 July 2019
    Status:
    Published
  3. How to create drug delivery systems based on supramolecular compounds, protein and carbon nanotubes?
    Authors:
    Jagusiak A., Piekarska B., Stopa B., Zemanek G., chłopaś K., Chmura O.
    Conference:
    3.3rd Congress of Polish Biosciences BIO2018 Through interdisciplinary approach into new solutions" and 51st Meeting of the Polish Biochemical Society and 14th Conference of the Polish Society for Cell Biology (rok: 2018, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 18-21 September 2018
    Status:
    Published
  4. Supramolecular ribbonlike Congo red and their interactions with albumin and immune complexes for medical drug delivery purposes
    Authors:
    Jagusiak A., Chłopaś K., Kościk I., Kwiecińska K.
    Conference:
    The 45th FEBS Congress (rok: 2021, ), Wydawca: John Wiley & Sons, Ltd FEBS Open Bio 11 (Suppl. 1)
    Data:
    konferencja 3-8 Lipca 2021
    Status:
    Published
  5. Supramolecular complexes of Congo red and Titan yellow with drugs (doxorubicin and imatinib) and their interactions with proteins (immunoglobulin light chain and albumin) for targeted drug delivery.
    Authors:
    G. Zemanek, M. Banach, A. Jagusiak, K. Chłopaś, B. Stopa, B. Piekarska, I. Roterman
    Conference:
    44th FEBS Congress From molecules to living systems" (rok: 2019, ), Wydawca: FEBS Open Bio 9 (Suppl. 1) July 2019
    Data:
    konferencja 6-11 July 2019
    Status:
    Published
  1. Congo red interactions with single-walled carbon nanotubes
    Authors:
    Anna Jagusiak, Barbara Piekarska, Katarzyna Chłopaś, Elżbieta Bielańska
    Book:
    Self-Assembled Molecules – New Kind of Protein Ligands. Supramolecular Ligands (rok: 2018, tom: nie dotyczy, strony: 121-132), Wydawca: Springer Open
    Status:
    Published
    DOI:
    link to the publication
  2. Metal ions introduced to proteins by supramolecular ligands
    Authors:
    Olga Woźnicka, Joanna Rybarska, Anna Jagusiak, Leszek Konieczny, Barbara Stopa, Irena Roterman
    Book:
    Self-Assembled Molecules – New Kind of Protein Ligands. Supramolecular Ligands (rok: 2018, tom: nie dotyczy, strony: 61-76), Wydawca: Springer Open
    Status:
    Published
    DOI:
    link to the publication
  3. Supramolecular Congo red as specific ligand of antibodies engaged in immune complex
    Authors:
    Anna Jagusiak, Joanna Rybarska, Barbara Piekarska, Barbara Stopa, Leszek Konieczny
    Book:
    Self-Assembled Molecules – New Kind of Protein Ligands. Supramolecular Ligands (rok: 2018, tom: nie dotyczy, strony: 21-41), Wydawca: Springer Open
    Status:
    Published
    DOI:
    link to the publication
  4. Supramolecular structures as carrier systems enabling the use of metal ions in antibacterial therapy
    Authors:
    Joanna Natkaniec, Anna Jagusiak, Joanna Rybarska, Tomasz Gosiewski, Jolanta Kaszuba-Zwoińska, Małgorzata Bulanda
    Book:
    Self-Assembled Molecules – New Kind of Protein Ligands. Supramolecular Ligands (rok: 2018, tom: nie dotyczy, strony: 101-120), Wydawca: Springer Open
    Status:
    Published
    DOI:
    link to the publication
  5. Protein Conditioning for bindng Congo Red and other supramolecular ligands
    Authors:
    Grzegorz Zemanek, Anna Jagusiak, Joanna Rybarska, Piotr Piwowar, Katarzyna Chłopaś, Irena Roterman
    Book:
    Self-Assembled Molecules – New Kind of Protein Ligands. Supramolecular Ligands (rok: 2018, tom: nie dotyczy, strony: 43-60), Wydawca: Springer Open
    Status:
    Published
    DOI:
    link to the publication

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